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DE-11.6

Submodule 13 genes

RNA splicing and spliceosomal complex assembly

This module comprises 13 genes including NCL, HNRNPA2B1, HNRNPD, MARCKS, and SFPQ, with strong enrichment for RNA splicing via transesterification reactions and spliceosomal complex assembly. No transcription factor knockdown data are available for this module. No repressing transcription factors are identified.

Key terms: RNA splicing, via transesterification reactions RNA splicing, via transesterification reactions with bulged adenosine as nucleophile mRNA splicing, via spliceosome mRNA processing Notable genes: NCL HNRNPA2B1 HNRNPD MARCKS SFPQ RAD21 HNRNPU LBR

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (13)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z
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