chr18 : 28,350,753 – 28,351,840

1,087 bp 76 TFs 1 linked gene

This 1.1 kb open chromatin element is linked to CDH2 and is bound by 76 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
CDH2		174.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

76 transcription factors

AR 1 dataset

ChIP LNCaP GSE80256.AR.LNCaP 235 bp overlap

Ahr::Arnt 2 datasets

Motif DE_12h DE_12h-AhrArnt_MA0006.2 5 bp overlap

Motif ES_0h ES_0h-AhrArnt_MA0006.2 5 bp overlap

CDX1 2 datasets

Motif DE_12h DE_12h-CDX1_MA0878.3 10 bp overlap

Motif ES_0h ES_0h-CDX1_MA0878.3 10 bp overlap

CDX4 2 datasets

Motif DE_12h DE_12h-CDX4_MA1473.2 9 bp overlap

Motif ES_0h ES_0h-CDX4_MA1473.2 9 bp overlap

CHD1 1 dataset

ChIP WA01 ENCSR000AQK.CHD1.WA01 153 bp overlap

CREB1 1 dataset

ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 175 bp overlap

CTCF 7 datasets

ChIP GM23338 ENCFF531QOI 262 bp overlap

ChIP H9 ENCFF152GTF 228 bp overlap

ChIP HeLa GSE126990.CTCF.HeLa 152 bp overlap

ChIP HeLa-Kyoto GSE138405.CTCF.HeLa-Kyoto 152 bp overlap

ChIP PC-3 ENCSR359LOD.CTCF.PC-3 97 bp overlap

ChIP endodermal cell ENCFF471YCZ 285 bp overlap

ChIP endodermal cell ENCFF471YCZ 82 bp overlap

CTCFL 4 datasets

Motif DE_12h DE_12h-CTCFL_MA1102.3 8 bp overlap

Motif ES_0h ES_0h-CTCFL_MA1102.3 8 bp overlap

ChIP Kelly_shLUC-res GSE115248.CTCFL.Kelly_shLUC-res 82 bp overlap

ChIP OVCAR-8 GSE70764.CTCFL.OVCAR-8 105 bp overlap

Ddit3::Cebpa 1 dataset

Motif DE_12h DE_12h-Ddit3Cebpa_MA0019.2 10 bp overlap

Dux 2 datasets

Motif DE_12h DE_12h-Dux_MA0611.3 11 bp overlap

Motif ES_0h ES_0h-Dux_MA0611.3 11 bp overlap

E2F6 2 datasets

ChIP H1 ENCFF785DWK 451 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 198 bp overlap

E2F7 2 datasets

Motif DE_12h DE_12h-E2F7_MA0758.1 14 bp overlap

Motif ES_0h ES_0h-E2F7_MA0758.1 14 bp overlap

E2F8 2 datasets

Motif DE_12h DE_12h-E2F8_MA0865.3 9 bp overlap

Motif ES_0h ES_0h-E2F8_MA0865.3 9 bp overlap

EWSR1-FLI1 2 datasets

Motif DE_12h DE_12h-EWSR1-FLI1_MA0149.1 18 bp overlap

Motif ES_0h ES_0h-EWSR1-FLI1_MA0149.1 18 bp overlap

FOXE1 2 datasets

Motif DE_12h DE_12h-FOXE1_MA1487.3 12 bp overlap

Motif ES_0h ES_0h-FOXE1_MA1487.3 12 bp overlap

GRHL2 2 datasets

ChIP LNCaP GSE80256.GRHL2.LNCaP 188 bp overlap

ChIP OVCA429 GSE71018.GRHL2.OVCA429 132 bp overlap

HOXA10 2 datasets

Motif DE_12h DE_12h-HOXA10_MA0899.2 9 bp overlap

Motif ES_0h ES_0h-HOXA10_MA0899.2 9 bp overlap

HOXB13 3 datasets

Motif DE_12h DE_12h-HOXB13_MA0901.3 9 bp overlap

Motif ES_0h ES_0h-HOXB13_MA0901.3 9 bp overlap

HOXD9 2 datasets

Motif DE_12h DE_12h-HOXD9_MA0913.3 9 bp overlap

Motif ES_0h ES_0h-HOXD9_MA0913.3 9 bp overlap

Hmga1 2 datasets

Motif DE_12h DE_12h-Hmga1_MA2124.1 8 bp overlap

Motif ES_0h ES_0h-Hmga1_MA2124.1 8 bp overlap

LIN54 2 datasets

Motif DE_12h DE_12h-LIN54_MA0619.2 7 bp overlap

Motif ES_0h ES_0h-LIN54_MA0619.2 7 bp overlap

Lhx3 2 datasets

Motif DE_12h DE_12h-Lhx3_MA0135.2 12 bp overlap

Motif ES_0h ES_0h-Lhx3_MA0135.2 12 bp overlap

MAF 1 dataset

Motif DE_12h DE_12h-MAF_MA1520.2 13 bp overlap

MAFA 1 dataset

Motif DE_12h DE_12h-MAFA_MA1521.2 13 bp overlap

MEF2B 2 datasets

Motif DE_12h DE_12h-MEF2B_MA0660.1 12 bp overlap

Motif ES_0h ES_0h-MEF2B_MA0660.1 12 bp overlap

MEF2D 2 datasets

Motif DE_12h DE_12h-MEF2D_MA0773.1 12 bp overlap

Motif ES_0h ES_0h-MEF2D_MA0773.1 12 bp overlap

MGA::EVX1 1 dataset

Motif DE_12h DE_12h-MGAEVX1_MA1960.2 11 bp overlap

MZF1 1 dataset

Motif DE_12h DE_12h-MZF1_MA0056.3 8 bp overlap

NANOG 3 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 522 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 278 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 287 bp overlap

NFYA 2 datasets

Motif DE_12h DE_12h-NFYA_MA0060.4 8 bp overlap

Motif ES_0h ES_0h-NFYA_MA0060.4 8 bp overlap

NFYC 2 datasets

Motif DE_12h DE_12h-NFYC_MA1644.2 7 bp overlap

Motif ES_0h ES_0h-NFYC_MA1644.2 7 bp overlap

PAX1 1 dataset

Motif DE_12h DE_12h-PAX1_MA0779.2 16 bp overlap

PBX1 2 datasets

Motif DE_12h DE_12h-PBX1_MA0070.2 9 bp overlap

Motif ES_0h ES_0h-PBX1_MA0070.2 9 bp overlap

POU1F1 2 datasets

Motif DE_12h DE_12h-POU1F1_MA0784.3 14 bp overlap

Motif ES_0h ES_0h-POU1F1_MA0784.3 14 bp overlap

POU2F1 2 datasets

Motif DE_12h DE_12h-POU2F1_MA0785.2 9 bp overlap

Motif ES_0h ES_0h-POU2F1_MA0785.2 9 bp overlap

POU2F1::SOX2 2 datasets

Motif DE_12h DE_12h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif ES_0h ES_0h-POU2F1SOX2_MA1962.1 17 bp overlap

POU2F2 2 datasets

Motif DE_12h DE_12h-POU2F2_MA0507.3 13 bp overlap

Motif ES_0h ES_0h-POU2F2_MA0507.3 13 bp overlap

POU2F3 2 datasets

Motif DE_12h DE_12h-POU2F3_MA0627.3 9 bp overlap

Motif ES_0h ES_0h-POU2F3_MA0627.3 9 bp overlap

POU3F1 2 datasets

Motif DE_12h DE_12h-POU3F1_MA0786.2 10 bp overlap

Motif ES_0h ES_0h-POU3F1_MA0786.2 10 bp overlap

POU3F2 2 datasets

Motif DE_12h DE_12h-POU3F2_MA0787.1 12 bp overlap

Motif ES_0h ES_0h-POU3F2_MA0787.1 12 bp overlap

POU3F3 2 datasets

Motif DE_12h DE_12h-POU3F3_MA0788.1 13 bp overlap

Motif ES_0h ES_0h-POU3F3_MA0788.1 13 bp overlap

POU3F4 2 datasets

Motif DE_12h DE_12h-POU3F4_MA0789.1 9 bp overlap

Motif ES_0h ES_0h-POU3F4_MA0789.1 9 bp overlap

POU5F1 1 dataset

ChIP HUES-8 GSE109524.POU5F1.HUES-8 508 bp overlap

POU5F1B 2 datasets

Motif DE_12h DE_12h-POU5F1B_MA0792.1 9 bp overlap

Motif ES_0h ES_0h-POU5F1B_MA0792.1 9 bp overlap

PRDM1 1 dataset

Motif DE_12h DE_12h-PRDM1_MA0508.4 7 bp overlap

Pgr 2 datasets

Motif DE_12h DE_12h-Pgr_MA2323.1 17 bp overlap

Motif ES_0h ES_0h-Pgr_MA2323.1 17 bp overlap

Pou5f1::Sox2 2 datasets

Motif DE_12h DE_12h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif ES_0h ES_0h-Pou5f1Sox2_MA0142.1 15 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 135 bp overlap

SALL3 1 dataset

ChIP hiPSC GSE104863.SALL3.hiPSC 264 bp overlap

SMAD2 2 datasets

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 299 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 295 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 325 bp overlap

SMAD2_3 1 dataset

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 327 bp overlap

SOX2 1 dataset

ChIP hiPSC GSE56567.SOX2.hiPSC 178 bp overlap

SP5 1 dataset

Motif DE_12h DE_12h-SP5_MA1965.2 6 bp overlap

SP8 2 datasets

Motif DE_12h DE_12h-SP8_MA0747.2 11 bp overlap

Motif ES_0h ES_0h-SP8_MA0747.2 11 bp overlap

SPIB 2 datasets

Motif DE_12h DE_12h-SPIB_MA0081.3 13 bp overlap

Motif ES_0h ES_0h-SPIB_MA0081.3 13 bp overlap

SPIC 2 datasets

Motif DE_12h DE_12h-SPIC_MA0687.2 13 bp overlap

Motif ES_0h ES_0h-SPIC_MA0687.2 13 bp overlap

Smad4 1 dataset

Motif DE_12h DE_12h-Smad4_MA1153.2 7 bp overlap

Spi1 2 datasets

Motif DE_12h DE_12h-Spi1_MA0080.7 13 bp overlap

Motif ES_0h ES_0h-Spi1_MA0080.7 13 bp overlap

TRIM28 1 dataset

ChIP hESC GSE115387.TRIM28.hESC 225 bp overlap

USF2 1 dataset

ChIP WTC11 ENCFF139JAW 417 bp overlap

YY1 2 datasets

ChIP H1 ENCFF524BTL 337 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 190 bp overlap

ZNF135 1 dataset

Motif DE_12h DE_12h-ZNF135_MA1587.1 14 bp overlap

ZNF184 1 dataset

Motif DE_12h DE_12h-ZNF184_MA2120.1 13 bp overlap

ZNF410 2 datasets

Motif DE_12h DE_12h-ZNF410_MA0752.2 16 bp overlap

Motif ES_0h ES_0h-ZNF410_MA0752.2 16 bp overlap

ZNF449 2 datasets

Motif DE_12h DE_12h-ZNF449_MA1656.2 10 bp overlap

Motif ES_0h ES_0h-ZNF449_MA1656.2 10 bp overlap

ZNF460 1 dataset

Motif DE_12h DE_12h-ZNF460_MA1596.1 16 bp overlap

ZNF462 1 dataset

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 142 bp overlap

ZNF530 2 datasets

Motif DE_12h DE_12h-ZNF530_MA1981.2 14 bp overlap

Motif ES_0h ES_0h-ZNF530_MA1981.2 14 bp overlap

ZNF549 2 datasets

Motif DE_12h DE_12h-ZNF549_MA1728.2 8 bp overlap

Motif ES_0h ES_0h-ZNF549_MA1728.2 8 bp overlap

ZNF701 2 datasets

Motif DE_12h DE_12h-ZNF701_MA1987.2 17 bp overlap

Motif ES_0h ES_0h-ZNF701_MA1987.2 17 bp overlap

ZNF76 2 datasets

Motif DE_12h DE_12h-ZNF76_MA1716.2 17 bp overlap

Motif ES_0h ES_0h-ZNF76_MA1716.2 17 bp overlap

ZNF770 2 datasets

Motif DE_12h DE_12h-ZNF770_MA2099.1 8 bp overlap

Motif ES_0h ES_0h-ZNF770_MA2099.1 8 bp overlap

ZNF85 2 datasets

Motif DE_12h DE_12h-ZNF85_MA1720.2 12 bp overlap

Motif ES_0h ES_0h-ZNF85_MA1720.2 12 bp overlap

Zfp809 2 datasets

Motif DE_12h DE_12h-Zfp809_MA2125.1 9 bp overlap

Motif ES_0h ES_0h-Zfp809_MA2125.1 9 bp overlap

Znf423 2 datasets

Motif DE_12h DE_12h-Znf423_MA0116.1 15 bp overlap

Motif ES_0h ES_0h-Znf423_MA0116.1 15 bp overlap