chr1 : 213,693,743 – 213,694,416

673 bp 89 TFs 2 linked genes

This 673 bp open chromatin element is linked to PROX1-AS1 and PROX1 and is bound by 89 transcription factors.

Linked Genes

2 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PROX1-AS1		293.7 kb	Distal	Multiome
PROX1		293.9 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

89 transcription factors

Atf3 1 dataset

Motif DE_72h DE_72h-Atf3_MA1988.2 7 bp overlap

BACH1 1 dataset

Motif DE_72h DE_72h-BACH1_MA1633.2 9 bp overlap

BATF 1 dataset

Motif DE_72h DE_72h-BATF_MA1634.2 7 bp overlap

BATF3 1 dataset

Motif DE_72h DE_72h-BATF3_MA0835.3 7 bp overlap

BATF::JUN 1 dataset

Motif DE_72h DE_72h-BATFJUN_MA0462.3 7 bp overlap

BNC2 1 dataset

Motif DE_72h DE_72h-BNC2_MA1928.2 7 bp overlap

BRD4 2 datasets

ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 343 bp overlap

ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 429 bp overlap

Crx 1 dataset

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

DMRTA1 2 datasets

Motif DE_48h DE_48h-DMRTA1_MA1707.2 10 bp overlap

Motif DE_72h DE_72h-DMRTA1_MA1707.2 10 bp overlap

DMRTC2 2 datasets

Motif DE_48h DE_48h-DMRTC2_MA1479.2 11 bp overlap

Motif DE_72h DE_72h-DMRTC2_MA1479.2 11 bp overlap

Dmbx1 1 dataset

Motif DE_48h DE_48h-Dmbx1_MA0883.2 10 bp overlap

ELF1 2 datasets

Motif DE_48h DE_48h-ELF1_MA0473.4 9 bp overlap

Motif DE_72h DE_72h-ELF1_MA0473.4 9 bp overlap

ELF3 2 datasets

Motif DE_48h DE_48h-ELF3_MA0640.3 9 bp overlap

Motif DE_72h DE_72h-ELF3_MA0640.3 9 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 266 bp overlap

Erg 2 datasets

Motif DE_48h DE_48h-Erg_MA0474.4 10 bp overlap

Motif DE_72h DE_72h-Erg_MA0474.4 10 bp overlap

FEZF2 1 dataset

Motif DE_48h DE_48h-FEZF2_MA2341.1 8 bp overlap

FOS 1 dataset

Motif DE_72h DE_72h-FOS_MA0476.2 8 bp overlap

FOS::JUND 1 dataset

Motif DE_72h DE_72h-FOSJUND_MA1141.2 9 bp overlap

FOSL1 1 dataset

Motif DE_72h DE_72h-FOSL1_MA0477.3 9 bp overlap

FOSL1::JUN 1 dataset

Motif DE_72h DE_72h-FOSL1JUN_MA1128.2 9 bp overlap

FOSL1::JUND 1 dataset

Motif DE_72h DE_72h-FOSL1JUND_MA1142.2 8 bp overlap

FOSL2::JUN 1 dataset

Motif DE_72h DE_72h-FOSL2JUN_MA1130.2 9 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 356 bp overlap

ChIP DE DE-FOXA2-2 427 bp overlap

FOXO1::ELF1 2 datasets

Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap

Motif DE_72h DE_72h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 2 datasets

Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap

Motif DE_72h DE_72h-FOXO1ELK1_MA1954.2 13 bp overlap

GABPA 2 datasets

Motif DE_48h DE_48h-GABPA_MA0062.4 10 bp overlap

Motif DE_72h DE_72h-GABPA_MA0062.4 10 bp overlap

GATA1 4 datasets

ChIP K-562 GSE107726.GATA1.K-562 338 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 157 bp overlap

ChIP erythroid-progenitor GSE124163.GATA1.erythroid-progenitor 189 bp overlap

ChIP erythroid_Don003 GSE137982.GATA1.erythroid_Don003 246 bp overlap

GATA2 6 datasets

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

ChIP K-562 ENCSR000EWG.GATA2.K-562 140 bp overlap

ChIP SH-SY5Y ENCFF485YIB 196 bp overlap

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 518 bp overlap

ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 292 bp overlap

ChIP hiPSC_SLC9ebs GSE107639.GATA2.hiPSC_SLC9ebs 282 bp overlap

GATA3 12 datasets

ChIP BE2C GSE65664.GATA3.BE2C 236 bp overlap

ChIP CLB-Ga GSE90683.GATA3.CLB-Ga 254 bp overlap

ChIP Kelly GSE65664.GATA3.Kelly 451 bp overlap

ChIP MCF-7_E2 GSE29073.GATA3.MCF-7_E2 116 bp overlap

ChIP NGP GSE65664.GATA3.NGP 154 bp overlap

ChIP SH-SY5Y ENCFF475HYF 481 bp overlap

ChIP SH-SY5Y ENCFF475HYF 288 bp overlap

ChIP SH-SY5Y ENCSR000EXZ.GATA3.SH-SY5Y 328 bp overlap

ChIP SK-N-BE2-C GSE94822.GATA3.SK-N-BE2-C 479 bp overlap

ChIP T-47D GSE51274.GATA3.T-47D 294 bp overlap

ChIP T-47D ENCSR000BMX.GATA3.T-47D 140 bp overlap

ChIP T-47D_sc GSE122847.GATA3.T-47D_sc 182 bp overlap

GATA3_Nter 2 datasets

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 206 bp overlap

ChIP T-47D_flp-ctrl GSE99479.GATA3_Nter.T-47D_flp-ctrl 193 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 673 bp overlap

ChIP DE DE-GATA4-2 673 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 468 bp overlap

GATA6 6 datasets

ChIP DE DE-GATA6-1 653 bp overlap

ChIP DE DE-GATA6-2 673 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 578 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 582 bp overlap

ChIP foregut GSE117136.GATA6.foregut 361 bp overlap

GSC 1 dataset

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

GSC2 1 dataset

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Gata3 1 dataset

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

HAND2 1 dataset

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 262 bp overlap

ISL1 1 dataset

ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 277 bp overlap

Ikzf3 1 dataset

Motif DE_72h DE_72h-Ikzf3_MA1992.2 9 bp overlap

JUN 2 datasets

ChIP DE_D2 S02-DE-d2-JUN-exp1 396 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 303 bp overlap

JUN::JUNB 1 dataset

Motif DE_72h DE_72h-JUNJUNB_MA1132.2 8 bp overlap

Jun 1 dataset

Motif DE_72h DE_72h-Jun_MA0489.3 8 bp overlap

KDM1A 1 dataset

ChIP SH-SY5Y_B3 GSE58258.KDM1A.SH-SY5Y_B3 168 bp overlap

MYCN 1 dataset

ChIP Kelly GSE94822.MYCN.Kelly 449 bp overlap

NANOG 2 datasets

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 307 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 208 bp overlap

NR1D1 1 dataset

Motif DE_72h DE_72h-NR1D1_MA1531.2 14 bp overlap

NR1D2 2 datasets

Motif DE_48h DE_48h-NR1D2_MA1532.2 15 bp overlap

Motif DE_72h DE_72h-NR1D2_MA1532.2 15 bp overlap

NR4A2::RXRA 2 datasets

Motif DE_48h DE_48h-NR4A2RXRA_MA1147.2 13 bp overlap

Motif DE_72h DE_72h-NR4A2RXRA_MA1147.2 13 bp overlap

Nr5A2 1 dataset

Motif DE_72h DE_72h-Nr5A2_MA0505.3 9 bp overlap

OSR2 2 datasets

Motif DE_48h DE_48h-OSR2_MA1646.2 8 bp overlap

Motif DE_72h DE_72h-OSR2_MA1646.2 8 bp overlap

OTX1 1 dataset

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

OTX2 1 dataset

Motif DE_48h DE_48h-OTX2_MA0712.3 7 bp overlap

PITX1 1 dataset

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap

PITX3 1 dataset

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

PRDM9 1 dataset

Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap

RARA::RXRG 1 dataset

Motif DE_72h DE_72h-RARARXRG_MA1149.2 17 bp overlap

RHOXF1 1 dataset

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

Rfx6 1 dataset

Motif DE_72h DE_72h-Rfx6_MA1724.2 9 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 161 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 578 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 437 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 452 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 141 bp overlap

SOX10 2 datasets

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap

SOX15 2 datasets

Motif DE_48h DE_48h-SOX15_MA1152.2 7 bp overlap

Motif DE_72h DE_72h-SOX15_MA1152.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 378 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 468 bp overlap

SOX18 2 datasets

Motif DE_48h DE_48h-SOX18_MA1563.2 8 bp overlap

Motif DE_72h DE_72h-SOX18_MA1563.2 8 bp overlap

SOX2 1 dataset

ChIP hiPSC GSE56567.SOX2.hiPSC 198 bp overlap

SOX4 2 datasets

Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap

Motif DE_72h DE_72h-SOX4_MA0867.3 8 bp overlap

SOX8 2 datasets

Motif DE_48h DE_48h-SOX8_MA0868.3 7 bp overlap

Motif DE_72h DE_72h-SOX8_MA0868.3 7 bp overlap

SOX9 2 datasets

Motif DE_48h DE_48h-SOX9_MA0077.2 8 bp overlap

Motif DE_72h DE_72h-SOX9_MA0077.2 8 bp overlap

SRY 2 datasets

Motif DE_48h DE_48h-SRY_MA0084.2 7 bp overlap

Motif DE_72h DE_72h-SRY_MA0084.2 7 bp overlap

STAT1 1 dataset

Motif DE_48h DE_48h-STAT1_MA0137.4 9 bp overlap

STAT3 1 dataset

Motif DE_48h DE_48h-STAT3_MA0144.3 9 bp overlap

Sox17 2 datasets

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Motif DE_72h DE_72h-Sox17_MA0078.3 10 bp overlap

Sox5 2 datasets

Motif DE_48h DE_48h-Sox5_MA0087.3 8 bp overlap

Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap

Sox6 4 datasets

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap

Sox7 2 datasets

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

Motif DE_72h DE_72h-Sox7_MA2095.1 10 bp overlap

Stat4 1 dataset

Motif DE_48h DE_48h-Stat4_MA0518.2 10 bp overlap

Stat6 1 dataset

Motif DE_48h DE_48h-Stat6_MA0520.2 10 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

TBX2 2 datasets

ChIP Kelly GSE94822.TBX2.Kelly 369 bp overlap

ChIP SK-N-BE2-C GSE94822.TBX2.SK-N-BE2-C 211 bp overlap

TFAP2A 3 datasets

Motif DE_48h DE_48h-TFAP2A_MA0810.2 11 bp overlap

Motif DE_72h DE_72h-TFAP2A_MA0810.2 11 bp overlap

ChIP WA09 GSE105081.TFAP2A.WA09 144 bp overlap

TFAP2B 3 datasets

Motif DE_48h DE_48h-TFAP2B_MA0811.2 11 bp overlap

Motif DE_72h DE_72h-TFAP2B_MA0811.2 11 bp overlap

ChIP SK-N-SH ENCFF869XXQ 441 bp overlap

TFAP2C 3 datasets

Motif DE_48h DE_48h-TFAP2C_MA0524.3 11 bp overlap

Motif DE_72h DE_72h-TFAP2C_MA0524.3 11 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 261 bp overlap

TRPS1 1 dataset

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

ZNF257 1 dataset

Motif DE_72h DE_72h-ZNF257_MA1710.2 10 bp overlap

ZNF281 1 dataset

Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap

Zfp809 1 dataset

Motif DE_48h DE_48h-Zfp809_MA2125.1 9 bp overlap