chr12 : 71,942,333 – 71,942,994
661 bp 79 TFs 1 linked gene
This 661 bp open chromatin element is linked to TPH2 and is bound by 79 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
TPH2 3.4 kb Proximal Proximity
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr12:71,937,333 – 71,947,994
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
79 transcription factors
Source
Cell type
ARID1B 2 datasets
ChIP K-562 ENCSR822CCM.ARID1B.K-562 346 bp overlap
ChIP K562 ENCFF938UXQ 255 bp overlap
ASCL1 1 dataset
ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 108 bp overlap
Ahr::Arnt 4 datasets
Motif DE_12h DE_12h-AhrArnt_MA0006.2 5 bp overlap
Motif DE_36h DE_36h-AhrArnt_MA0006.2 5 bp overlap
Motif DE_48h DE_48h-AhrArnt_MA0006.2 5 bp overlap
Motif DE_60h DE_60h-AhrArnt_MA0006.2 5 bp overlap
BARX2 1 dataset
Motif DE_60h DE_60h-BARX2_MA1471.2 9 bp overlap
BRD4 2 datasets
ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 179 bp overlap
ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 129 bp overlap
CBFA2T2 2 datasets
ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 234 bp overlap
ChIP K562 ENCFF963TXY 308 bp overlap
CBFA2T3 3 datasets
ChIP K-562 GSE142227.CBFA2T3.K-562 234 bp overlap
ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 316 bp overlap
ChIP K562 ENCFF673OEZ 254 bp overlap
CEBPD 1 dataset
ChIP K-562 ENCSR000BVY.CEBPD.K-562 184 bp overlap
CHD2 1 dataset
ChIP SK-N-SH ENCSR274SLQ.CHD2.SK-N-SH 238 bp overlap
CREM 2 datasets
ChIP K-562 ENCSR077DKV.CREM.K-562 111 bp overlap
ChIP K562 ENCFF180STA 292 bp overlap
EBF3 4 datasets
Motif DE_12h DE_12h-EBF3_MA1637.2 9 bp overlap
Motif DE_36h DE_36h-EBF3_MA1637.2 9 bp overlap
Motif DE_48h DE_48h-EBF3_MA1637.2 9 bp overlap
Motif DE_60h DE_60h-EBF3_MA1637.2 9 bp overlap
EBF3_P177L 1 dataset
ChIP SK-N-SH GSE90682.EBF3_P177L.SK-N-SH 303 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 132 bp overlap
EP300 4 datasets
ChIP K-562 ENCSR000EGE.EP300.K-562 143 bp overlap
ChIP K562 ENCFF226VMS 312 bp overlap
ChIP SK-N-SH ENCFF829RWA 270 bp overlap
ChIP SK-N-SH ENCSR000EHV.EP300.SK-N-SH 218 bp overlap
Ebf2 4 datasets
Motif DE_12h DE_12h-Ebf2_MA1604.2 9 bp overlap
Motif DE_36h DE_36h-Ebf2_MA1604.2 9 bp overlap
Motif DE_48h DE_48h-Ebf2_MA1604.2 9 bp overlap
Motif DE_60h DE_60h-Ebf2_MA1604.2 9 bp overlap
FOS 1 dataset
ChIP MCF-7 ENCFF282FWZ 94 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 338 bp overlap
ChIP DE DE-FOXA2-2 339 bp overlap
FOXJ3 1 dataset
ChIP SK-N-SH ENCFF124KVL 383 bp overlap
GATA1 4 datasets
ChIP HUDEP-2_30min GSE104676.GATA1.HUDEP-2_30min 205 bp overlap
ChIP K-562 GSE107726.GATA1.K-562 300 bp overlap
ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 243 bp overlap
ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 283 bp overlap
GATA1::TAL1 4 datasets
Motif DE_12h DE_12h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_36h DE_36h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap
GATA2 11 datasets
Motif DE_12h DE_12h-GATA2_MA0036.4 7 bp overlap
Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap
Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap
Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap
ChIP K-562 ENCSR000EWG.GATA2.K-562 249 bp overlap
ChIP K-562 ENCSR000BKM.GATA2.K-562 141 bp overlap
ChIP K562 ENCFF544PCK 241 bp overlap
ChIP SH-SY5Y ENCFF485YIB 356 bp overlap
ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 326 bp overlap
ChIP SK-N-SH ENCFF764OZD 333 bp overlap
ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 269 bp overlap
GATA3 1 dataset
ChIP SH-SY5Y ENCSR000EXZ.GATA3.SH-SY5Y 337 bp overlap
GATA4 9 datasets
ChIP DE DE-GATA4-1 388 bp overlap
ChIP DE DE-GATA4-2 475 bp overlap
Motif DE_12h DE_12h-GATA4_MA0482.3 8 bp overlap
Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap
ChIP cardiomyocyte_5 GSE85628.GATA4.cardiomyocyte_5 95 bp overlap
ChIP foregut GSE117136.GATA4.foregut 319 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 245 bp overlap
GATA5 4 datasets
Motif DE_12h DE_12h-GATA5_MA0766.3 8 bp overlap
Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap
Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap
Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap
GATA6 16 datasets
ChIP DE DE-GATA6-1 381 bp overlap
ChIP DE DE-GATA6-2 428 bp overlap
Motif DE_12h DE_12h-GATA6_MA1104.3 8 bp overlap
Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap
Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap
Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 491 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 434 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 437 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 462 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 467 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 629 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 389 bp overlap
ChIP foregut GSE117136.GATA6.foregut 404 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 386 bp overlap
ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 296 bp overlap
Gata3 4 datasets
Motif DE_12h DE_12h-Gata3_MA0037.5 8 bp overlap
Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap
Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap
Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap
HAND2 2 datasets
ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 250 bp overlap
ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 135 bp overlap
HDAC2 1 dataset
ChIP K-562 ENCSR000BMG.HDAC2.K-562 155 bp overlap
HMBOX1 1 dataset
ChIP K-562 ENCSR757IIU.HMBOX1.K-562 325 bp overlap
Hand1 2 datasets
Motif DE_36h DE_36h-Hand1_MA2123.1 9 bp overlap
Motif DE_60h DE_60h-Hand1_MA2123.1 9 bp overlap
INSM1 1 dataset
Motif DE_60h DE_60h-INSM1_MA0155.1 12 bp overlap
ISL1 2 datasets
ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 302 bp overlap
ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 164 bp overlap
Isl1 1 dataset
Motif DE_60h DE_60h-Isl1_MA1608.2 7 bp overlap
KDM1A 1 dataset
ChIP K-562 GSE117944.KDM1A.K-562 176 bp overlap
LDB1 2 datasets
ChIP HEP GSE52637.LDB1.HEP 115 bp overlap
ChIP K-562 GSE142227.LDB1.K-562 400 bp overlap
MSC 3 datasets
Motif DE_36h DE_36h-MSC_MA0665.1 10 bp overlap
Motif DE_48h DE_48h-MSC_MA0665.1 10 bp overlap
Motif DE_60h DE_60h-MSC_MA0665.1 10 bp overlap
MXI1 1 dataset
ChIP SK-N-SH ENCSR000EIA.MXI1.SK-N-SH 162 bp overlap
MYCN 1 dataset
ChIP COG-N-415 GSE138295.MYCN.COG-N-415 198 bp overlap
MYNN 1 dataset
ChIP K-562 ENCSR737LTZ.MYNN.K-562 130 bp overlap
Mecom 4 datasets
Motif DE_12h DE_12h-Mecom_MA0029.2 11 bp overlap
Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap
Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap
Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap
NANOG 1 dataset
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 331 bp overlap
NEUROD1 1 dataset
ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 200 bp overlap
NEUROG2 4 datasets
ChIP MRC-5_NFD_02DPT GSE75910.NEUROG2.MRC-5_NFD_02DPT 163 bp overlap
ChIP MRC-5_NFD_1DPT GSE75910.NEUROG2.MRC-5_NFD_1DPT 195 bp overlap
ChIP MRC-5_N_02DPT GSE75910.NEUROG2.MRC-5_N_02DPT 161 bp overlap
ChIP MRC-5_N_1DPT GSE75910.NEUROG2.MRC-5_N_1DPT 221 bp overlap
NFATC3 4 datasets
Motif DE_12h DE_12h-NFATC3_MA0625.3 6 bp overlap
Motif DE_36h DE_36h-NFATC3_MA0625.3 6 bp overlap
Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap
Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap
NR2F2 1 dataset
ChIP K-562 ENCSR000BRS.NR2F2.K-562 232 bp overlap
Nfatc1 4 datasets
Motif DE_12h DE_12h-Nfatc1_MA0624.3 6 bp overlap
Motif DE_36h DE_36h-Nfatc1_MA0624.3 6 bp overlap
Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap
Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap
Nfatc2 4 datasets
Motif DE_12h DE_12h-Nfatc2_MA0152.3 8 bp overlap
Motif DE_36h DE_36h-Nfatc2_MA0152.3 8 bp overlap
Motif DE_48h DE_48h-Nfatc2_MA0152.3 8 bp overlap
Motif DE_60h DE_60h-Nfatc2_MA0152.3 8 bp overlap
PHOX2B 1 dataset
ChIP CLB-Ga GSE90683.PHOX2B.CLB-Ga 271 bp overlap
PKNOX2 3 datasets
Motif DE_36h DE_36h-PKNOX2_MA0783.1 12 bp overlap
Motif DE_48h DE_48h-PKNOX2_MA0783.1 12 bp overlap
Motif DE_60h DE_60h-PKNOX2_MA0783.1 12 bp overlap
POLR2A 1 dataset
ChIP K562 ENCFF514URW 349 bp overlap
RAD21 2 datasets
ChIP SK-N-SH ENCFF747MAS 174 bp overlap
ChIP SK-N-SH ENCSR000EHX.RAD21.SK-N-SH 131 bp overlap
RCOR1 3 datasets
ChIP SK-N-SH ENCFF518EXB 301 bp overlap
ChIP SK-N-SH ENCSR009TKN.RCOR1.SK-N-SH 210 bp overlap
ChIP SK-N-SH ENCSR009TKN.RCOR1.SK-N-SH 188 bp overlap
REST 1 dataset
ChIP K-562 ENCSR000BMW.REST.K-562 126 bp overlap
Rhox11 3 datasets
Motif DE_36h DE_36h-Rhox11_MA0629.2 9 bp overlap
Motif DE_48h DE_48h-Rhox11_MA0629.2 9 bp overlap
Motif DE_60h DE_60h-Rhox11_MA0629.2 9 bp overlap
SMARCA4 2 datasets
ChIP K-562 ENCSR587OQL.SMARCA4.K-562 231 bp overlap
ChIP hiPSC GSE124903.SMARCA4.hiPSC 282 bp overlap
SMARCC1 1 dataset
ChIP hiPSC GSE124903.SMARCC1.hiPSC 225 bp overlap
SMARCE1 1 dataset
ChIP K-562 ENCSR157TCS.SMARCE1.K-562 326 bp overlap
SPI1 1 dataset
ChIP NCI-H929 GSE56857.SPI1.NCI-H929 127 bp overlap
STAT1::STAT2 1 dataset
Motif DE_60h DE_60h-STAT1STAT2_MA0517.2 13 bp overlap
STAT5A 2 datasets
ChIP K-562 ENCSR000BRR.STAT5A.K-562 232 bp overlap
ChIP K562 ENCFF226BTJ 340 bp overlap
TAL1 9 datasets
ChIP K-562 GSE107726.TAL1.K-562 250 bp overlap
ChIP K-562 ENCSR000EHB.TAL1.K-562 197 bp overlap
ChIP K-562_dCas9-KRAB GSE132212.TAL1.K-562_dCas9-KRAB 270 bp overlap
ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 217 bp overlap
ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 266 bp overlap
ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 243 bp overlap
ChIP K-562_sgGal4 GSE132212.TAL1.K-562_sgGal4 187 bp overlap
ChIP K562 ENCFF661CCK 277 bp overlap
ChIP ProEs GSE59087.TAL1.ProEs 117 bp overlap
TARDBP 1 dataset
ChIP K-562 ENCSR353HEP.TARDBP.K-562 99 bp overlap
TBX2 1 dataset
ChIP Kelly GSE94822.TBX2.Kelly 218 bp overlap
TBX5 4 datasets
ChIP G296S GSE85628.TBX5.G296S 214 bp overlap
ChIP G296S_2 GSE85628.TBX5.G296S_2 214 bp overlap
ChIP G296S_4 GSE85628.TBX5.G296S_4 247 bp overlap
ChIP hiPSC GSE81585.TBX5.hiPSC 216 bp overlap
TCF12 2 datasets
ChIP K-562 ENCSR744WOO.TCF12.K-562 221 bp overlap
ChIP K562 ENCFF931DJY 385 bp overlap
TEAD4 1 dataset
ChIP K562 ENCFF673NIK 341 bp overlap
TFAP2B 5 datasets
Motif DE_12h DE_12h-TFAP2B_MA0812.2 9 bp overlap
Motif DE_36h DE_36h-TFAP2B_MA0812.2 9 bp overlap
Motif DE_48h DE_48h-TFAP2B_MA0812.2 9 bp overlap
Motif DE_60h DE_60h-TFAP2B_MA0812.2 9 bp overlap
ChIP SK-N-SH ENCFF869XXQ 180 bp overlap
TGIF1 3 datasets
Motif DE_36h DE_36h-TGIF1_MA0796.1 12 bp overlap
Motif DE_48h DE_48h-TGIF1_MA0796.1 12 bp overlap
Motif DE_60h DE_60h-TGIF1_MA0796.1 12 bp overlap
TGIF2 3 datasets
Motif DE_36h DE_36h-TGIF2_MA0797.1 12 bp overlap
Motif DE_48h DE_48h-TGIF2_MA0797.1 12 bp overlap
Motif DE_60h DE_60h-TGIF2_MA0797.1 12 bp overlap
TRPS1 4 datasets
Motif DE_12h DE_12h-TRPS1_MA1970.2 8 bp overlap
Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap
Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap
Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap
Tcf21 3 datasets
Motif DE_36h DE_36h-Tcf21_MA0832.2 10 bp overlap
Motif DE_48h DE_48h-Tcf21_MA0832.2 10 bp overlap
Motif DE_60h DE_60h-Tcf21_MA0832.2 10 bp overlap
VENTX 1 dataset
Motif DE_60h DE_60h-VENTX_MA0724.1 9 bp overlap
ZBTB7A 2 datasets
ChIP HUDEP-2 GSE103445.ZBTB7A.HUDEP-2 328 bp overlap
ChIP K-562 GSE103445.ZBTB7A.K-562 229 bp overlap
ZFP42 4 datasets
Motif DE_12h DE_12h-ZFP42_MA1651.2 13 bp overlap
Motif DE_36h DE_36h-ZFP42_MA1651.2 13 bp overlap
Motif DE_48h DE_48h-ZFP42_MA1651.2 13 bp overlap
Motif DE_60h DE_60h-ZFP42_MA1651.2 13 bp overlap
ZIM3 1 dataset
Motif DE_60h DE_60h-ZIM3_MA1709.2 11 bp overlap
ZNF547 4 datasets
Motif DE_12h DE_12h-ZNF547_MA2334.1 13 bp overlap
Motif DE_36h DE_36h-ZNF547_MA2334.1 13 bp overlap
Motif DE_48h DE_48h-ZNF547_MA2334.1 13 bp overlap
Motif DE_60h DE_60h-ZNF547_MA2334.1 13 bp overlap
ZNF558 3 datasets
Motif DE_36h DE_36h-ZNF558_MA2335.1 29 bp overlap
Motif DE_48h DE_48h-ZNF558_MA2335.1 29 bp overlap
Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap
ZNF766 1 dataset
Motif DE_60h DE_60h-ZNF766_MA2098.1 9 bp overlap
ZNF93 1 dataset
Motif DE_60h DE_60h-ZNF93_MA1721.2 14 bp overlap
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