chr16 : 86,313,528 – 86,314,042

514 bp 92 TFs 1 linked gene

This 514 bp open chromatin element is linked to MTHFSD and is bound by 92 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
MTHFSD		241.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

92 transcription factors

BARHL1 1 dataset

Motif DE_48h DE_48h-BARHL1_MA0877.4 6 bp overlap

BARHL2 1 dataset

Motif DE_48h DE_48h-BARHL2_MA0635.2 6 bp overlap

BCL11A 1 dataset

Motif DE_48h DE_48h-BCL11A_MA2324.1 7 bp overlap

CBX2 1 dataset

ChIP K-562 ENCSR000ATU.CBX2.K-562 339 bp overlap

CBX8 1 dataset

ChIP A-549 ENCSR616MOB.CBX8.A-549 253 bp overlap

CTCF 1 dataset

Motif DE_48h DE_48h-CTCF_MA1930.2 33 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF262VBH 152 bp overlap

ChIP BLaER1 ENCFF335XTP 142 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 486 bp overlap

ERF::FOXI1 1 dataset

Motif DE_48h DE_48h-ERFFOXI1_MA1935.2 10 bp overlap

ERG 1 dataset

ChIP aortic-endothelial-cell_D47 GSE139377.ERG.aortic-endothelial-cell_D47 182 bp overlap

ESR1 1 dataset

ChIP MCF-7_E2-40min-ERalpha GSE94023.ESR1.MCF-7_E2-40min-ERalpha 157 bp overlap

ETS1 1 dataset

ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 216 bp overlap

ETV1 1 dataset

Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap

ETV2::DRGX 1 dataset

Motif DE_48h DE_48h-ETV2DRGX_MA1940.2 12 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_48h DE_48h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::DRGX 1 dataset

Motif DE_48h DE_48h-ETV5DRGX_MA1944.2 12 bp overlap

EWSR1-FLI1 1 dataset

Motif DE_48h DE_48h-EWSR1-FLI1_MA0149.1 18 bp overlap

EZH2 1 dataset

ChIP PC-9 ENCSR793USK.EZH2.PC-9 514 bp overlap

EZH2_phosphoT487 1 dataset

ChIP PC-9 ENCSR702GMW.EZH2_phosphoT487.PC-9 451 bp overlap

Erg 1 dataset

Motif DE_48h DE_48h-Erg_MA0474.4 10 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_48h DE_48h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA1 1 dataset

Motif DE_48h DE_48h-FOXA1_MA0148.5 8 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 514 bp overlap

ChIP DE DE-FOXA2-2 514 bp overlap

Motif DE_48h DE_48h-FOXA2_MA0047.4 8 bp overlap

FOXA3 1 dataset

Motif DE_48h DE_48h-FOXA3_MA1683.2 7 bp overlap

FOXB1 1 dataset

Motif DE_48h DE_48h-FOXB1_MA0845.1 11 bp overlap

FOXC1 1 dataset

Motif DE_48h DE_48h-FOXC1_MA0032.2 11 bp overlap

FOXC2 1 dataset

Motif DE_48h DE_48h-FOXC2_MA0846.2 11 bp overlap

FOXD1 1 dataset

Motif DE_48h DE_48h-FOXD1_MA0031.2 7 bp overlap

FOXD2 1 dataset

Motif DE_48h DE_48h-FOXD2_MA0847.4 11 bp overlap

FOXD3 1 dataset

Motif DE_48h DE_48h-FOXD3_MA0041.3 14 bp overlap

FOXF2 1 dataset

Motif DE_48h DE_48h-FOXF2_MA0030.2 9 bp overlap

FOXG1 1 dataset

Motif DE_48h DE_48h-FOXG1_MA0613.1 8 bp overlap

FOXI1 1 dataset

Motif DE_48h DE_48h-FOXI1_MA0042.2 7 bp overlap

FOXJ2::ELF1 1 dataset

Motif DE_48h DE_48h-FOXJ2ELF1_MA1952.2 11 bp overlap

FOXK1 1 dataset

Motif DE_48h DE_48h-FOXK1_MA0852.3 7 bp overlap

FOXK2 1 dataset

Motif DE_48h DE_48h-FOXK2_MA1103.3 7 bp overlap

FOXL1 1 dataset

Motif DE_48h DE_48h-FOXL1_MA0033.2 7 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::ELK3 1 dataset

Motif DE_48h DE_48h-FOXO1ELK3_MA1955.2 13 bp overlap

FOXO4 1 dataset

Motif DE_48h DE_48h-FOXO4_MA0848.1 7 bp overlap

FOXO6 1 dataset

Motif DE_48h DE_48h-FOXO6_MA0849.1 7 bp overlap

FOXP1 1 dataset

Motif DE_48h DE_48h-FOXP1_MA0481.4 7 bp overlap

FOXP2 1 dataset

Motif DE_48h DE_48h-FOXP2_MA0593.2 9 bp overlap

FOXP3 1 dataset

Motif DE_48h DE_48h-FOXP3_MA0850.1 7 bp overlap

FOXP4 1 dataset

Motif DE_48h DE_48h-FOXP4_MA2117.1 7 bp overlap

FOXS1 1 dataset

Motif DE_48h DE_48h-FOXS1_MA2118.1 8 bp overlap

Foxf1 1 dataset

Motif DE_48h DE_48h-Foxf1_MA1606.2 7 bp overlap

Foxj2 1 dataset

Motif DE_48h DE_48h-Foxj2_MA0614.1 8 bp overlap

Foxj3 1 dataset

Motif DE_48h DE_48h-Foxj3_MA0851.2 9 bp overlap

Foxl2 1 dataset

Motif DE_48h DE_48h-Foxl2_MA1607.2 10 bp overlap

Foxo1 1 dataset

Motif DE_48h DE_48h-Foxo1_MA0480.3 7 bp overlap

Foxo3 1 dataset

Motif DE_48h DE_48h-Foxo3_MA0157.4 7 bp overlap

Foxq1 1 dataset

Motif DE_48h DE_48h-Foxq1_MA0040.2 10 bp overlap

GABPA 1 dataset

Motif DE_48h DE_48h-GABPA_MA0062.4 10 bp overlap

GATA3 1 dataset

ChIP MCF-7_sgScr GSE133072.GATA3.MCF-7_sgScr 131 bp overlap

GATA4 5 datasets

ChIP DE DE-GATA4-1 514 bp overlap

ChIP DE DE-GATA4-2 514 bp overlap

ChIP foregut GSE117136.GATA4.foregut 449 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 345 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 283 bp overlap

GATA5 1 dataset

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

GATA6 14 datasets

ChIP DE DE-GATA6-1 514 bp overlap

ChIP DE DE-GATA6-2 514 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 514 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 514 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 514 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 514 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 514 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 514 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 514 bp overlap

ChIP foregut GSE117136.GATA6.foregut 418 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 404 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 259 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 315 bp overlap

Gata3 1 dataset

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Gli1 1 dataset

Motif DE_48h DE_48h-Gli1_MA1990.2 10 bp overlap

Gli2 1 dataset

Motif DE_48h DE_48h-Gli2_MA0734.4 9 bp overlap

IKZF1 1 dataset

Motif DE_48h DE_48h-IKZF1_MA1508.2 8 bp overlap

IKZF2 1 dataset

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

Ikzf3 1 dataset

Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap

JUN 2 datasets

ChIP DE_D1 S40-DE-d1-JUN-exp2 312 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 498 bp overlap

MEIS1 1 dataset

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Mecom 1 dataset

Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap

ONECUT1 1 dataset

Motif DE_48h DE_48h-ONECUT1_MA0679.3 9 bp overlap

PAX9 1 dataset

Motif DE_48h DE_48h-PAX9_MA0781.2 16 bp overlap

PKNOX1 1 dataset

Motif DE_48h DE_48h-PKNOX1_MA0782.3 10 bp overlap

PRDM1 1 dataset

Motif DE_48h DE_48h-PRDM1_MA0508.4 7 bp overlap

PRDM6 2 datasets

ChIP HEK293 ENCFF283AJL 288 bp overlap

ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 263 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 514 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 514 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 469 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 415 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 514 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 386 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 514 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 514 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 315 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 319 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 321 bp overlap

ChIP TTC-549_NoDox GSE71504.SMARCC1.TTC-549_NoDox 191 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 442 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 484 bp overlap

SUZ12 2 datasets

ChIP CRL-7250_shSS18-SSX GSE108025.SUZ12.CRL-7250_shSS18-SSX 289 bp overlap

ChIP LNCaP GSE39459.SUZ12.LNCaP 260 bp overlap

Stat5a 1 dataset

Motif DE_48h DE_48h-Stat5a_MA1624.2 9 bp overlap

Stat5a::Stat5b 1 dataset

Motif DE_48h DE_48h-Stat5aStat5b_MA0519.2 9 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 360 bp overlap

TRPS1 1 dataset

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

ZIC1 1 dataset

Motif DE_48h DE_48h-ZIC1_MA0696.1 14 bp overlap

ZIC2 1 dataset

ChIP HEK293 ENCFF033NQQ 260 bp overlap

ZIC4 1 dataset

Motif DE_48h DE_48h-ZIC4_MA0751.2 14 bp overlap

ZIC5 1 dataset

Motif DE_48h DE_48h-ZIC5_MA1584.2 15 bp overlap

ZKSCAN1 1 dataset

Motif DE_48h DE_48h-ZKSCAN1_MA1585.2 9 bp overlap

ZNF175 1 dataset

Motif DE_48h DE_48h-ZNF175_MA2332.1 9 bp overlap

ZNF382 1 dataset

Motif DE_48h DE_48h-ZNF382_MA1594.1 24 bp overlap

ZNF768 1 dataset

Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap