Enables RNA binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTHFSD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTHFSD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTHFSD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:86,313,528–86,314,042 | 241.4 kb | Distal (>10kb) Multiome | 92 | |
| chr16:86,497,100–86,498,040 | 57.6 kb | Distal (>10kb) Multiome | 175 | |
| chr16:86,508,009–86,508,953 | 46.7 kb | Distal (>10kb) Multiome | 202 | |
| chr16:86,509,426–86,510,903 | 44.8 kb | Distal (>10kb) Multiome | 411 | |
| chr16:86,554,821–86,555,589 | 14 bp | At TSS Multiome | 807 | |
| chr16:86,563,831–86,564,141 | 8.6 kb | Proximal (<10kb) | 517 | |
| chr16:86,566,642–86,567,607 | 11.7 kb | Distal (>10kb) Multiome | 265 | |
| chr16:86,568,152–86,568,627 | 13.3 kb | Distal (>10kb) Multiome | 109 | |
| chr16:86,575,594–86,576,621 | 20.9 kb | Distal (>10kb) Multiome | 504 | |
| chr16:86,818,869–86,819,448 | 263.9 kb | Distal (>10kb) Multiome | 146 | |
| chr16:87,047,118–87,047,923 | 492.2 kb | Distal (>10kb) Multiome HiCAR | 133 | |
| chr16:87,264,671–87,265,109 | 709.7 kb | Distal (>10kb) Multiome HiCAR | 88 | |
| chr16:87,278,468–87,279,093 | 723.6 kb | Distal (>10kb) Multiome HiCAR | 284 | |
| chr16:87,305,529–87,306,047 | 750.6 kb | Distal (>10kb) Multiome HiCAR | 282 | |
| chr16:87,316,905–87,317,759 | 762.2 kb | Distal (>10kb) Multiome HiCAR | 945 |
Genomic view of the MTHFSD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.