chr15 : 33,231,008 – 33,231,810

802 bp 117 TFs 1 linked gene

This 802 bp open chromatin element is linked to RYR3 and is bound by 117 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
RYR3		79.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

117 transcription factors

ALX3 1 dataset

Motif DE_48h DE_48h-ALX3_MA0634.2 6 bp overlap

AR 2 datasets

ChIP LNCaP_R1881 GSE69043.AR.LNCaP_R1881 150 bp overlap

ChIP LNCaP_SHGATA2_R1881 GSE69043.AR.LNCaP_SHGATA2_R1881 107 bp overlap

Alx1 1 dataset

Motif DE_36h DE_36h-Alx1_MA0854.2 8 bp overlap

Arid3a 1 dataset

Motif DE_36h DE_36h-Arid3a_MA0151.1 6 bp overlap

BARX1 1 dataset

Motif DE_36h DE_36h-BARX1_MA0875.2 6 bp overlap

BARX2 1 dataset

Motif DE_48h DE_48h-BARX2_MA1471.2 9 bp overlap

BRD4 3 datasets

ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 661 bp overlap

ChIP Kelly_resistant_JQ1 GSE103030.BRD4.Kelly_resistant_JQ1 213 bp overlap

ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 261 bp overlap

BSX 1 dataset

Motif DE_36h DE_36h-BSX_MA0876.2 6 bp overlap

CTCFL 1 dataset

ChIP Kelly_resistant GSE103030.CTCFL.Kelly_resistant 185 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF262VBH 137 bp overlap

DLX1 1 dataset

Motif DE_36h DE_36h-DLX1_MA0879.3 6 bp overlap

DLX6 1 dataset

Motif DE_36h DE_36h-DLX6_MA0882.2 6 bp overlap

DRGX 1 dataset

Motif DE_48h DE_48h-DRGX_MA1481.2 6 bp overlap

DUX4 1 dataset

Motif DE_36h DE_36h-DUX4_MA0468.1 11 bp overlap

DUXA 1 dataset

Motif DE_36h DE_36h-DUXA_MA0884.2 13 bp overlap

Dlx3 1 dataset

Motif DE_36h DE_36h-Dlx3_MA0880.2 6 bp overlap

Dlx4 1 dataset

Motif DE_36h DE_36h-Dlx4_MA0881.2 6 bp overlap

Dux 1 dataset

Motif DE_36h DE_36h-Dux_MA0611.3 11 bp overlap

EBF1 2 datasets

Motif DE_36h DE_36h-EBF1_MA0154.5 11 bp overlap

Motif DE_48h DE_48h-EBF1_MA0154.5 11 bp overlap

EBF3 2 datasets

Motif DE_36h DE_36h-EBF3_MA1637.2 9 bp overlap

Motif DE_48h DE_48h-EBF3_MA1637.2 9 bp overlap

EMX1 1 dataset

Motif DE_48h DE_48h-EMX1_MA0612.3 6 bp overlap

EMX2 1 dataset

Motif DE_48h DE_48h-EMX2_MA0886.2 6 bp overlap

EN1 1 dataset

Motif DE_48h DE_48h-EN1_MA0027.3 6 bp overlap

EOMES 2 datasets

Motif DE_36h DE_36h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 465 bp overlap

ERF::FOXO1 1 dataset

Motif DE_48h DE_48h-ERFFOXO1_MA1936.2 12 bp overlap

ERF::SREBF2 1 dataset

Motif DE_48h DE_48h-ERFSREBF2_MA1939.2 16 bp overlap

ERG 1 dataset

ChIP VCaP GSE49091.ERG.VCaP 181 bp overlap

EVX1 1 dataset

Motif DE_48h DE_48h-EVX1_MA0887.2 6 bp overlap

EVX2 1 dataset

Motif DE_48h DE_48h-EVX2_MA0888.2 6 bp overlap

Ebf2 2 datasets

Motif DE_36h DE_36h-Ebf2_MA1604.2 9 bp overlap

Motif DE_48h DE_48h-Ebf2_MA1604.2 9 bp overlap

Ebf4 2 datasets

Motif DE_36h DE_36h-Ebf4_MA2122.1 11 bp overlap

Motif DE_48h DE_48h-Ebf4_MA2122.1 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 612 bp overlap

ChIP DE DE-FOXA2-2 534 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_48h DE_48h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA2 6 datasets

ChIP LNCaP GSE38391.GATA2.LNCaP 194 bp overlap

ChIP LNCaP GSE52725.GATA2.LNCaP 194 bp overlap

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 259 bp overlap

ChIP LNCaP_FBS GSE69043.GATA2.LNCaP_FBS 148 bp overlap

ChIP VCaP GSE125236.GATA2.VCaP 217 bp overlap

ChIP VCaP_JQ1 GSE125236.GATA2.VCaP_JQ1 161 bp overlap

GATA3 1 dataset

ChIP Kelly GSE65664.GATA3.Kelly 235 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 517 bp overlap

ChIP DE DE-GATA4-2 650 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 655 bp overlap

ChIP DE DE-GATA6-2 676 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 607 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 624 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 591 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 649 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 727 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 628 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 474 bp overlap

GBX2 1 dataset

Motif DE_36h DE_36h-GBX2_MA0890.2 6 bp overlap

GSX1 1 dataset

Motif DE_48h DE_48h-GSX1_MA0892.2 6 bp overlap

GSX2 1 dataset

Motif DE_48h DE_48h-GSX2_MA0893.3 7 bp overlap

HESX1 1 dataset

Motif DE_36h DE_36h-HESX1_MA0894.2 6 bp overlap

HMBOX1 1 dataset

Motif DE_48h DE_48h-HMBOX1_MA0895.2 7 bp overlap

HOXA1 1 dataset

Motif DE_48h DE_48h-HOXA1_MA1495.2 6 bp overlap

HOXA2 1 dataset

Motif DE_48h DE_48h-HOXA2_MA0900.3 6 bp overlap

HOXA3 1 dataset

Motif DE_48h DE_48h-HOXA3_MA2119.1 7 bp overlap

HOXA5 1 dataset

Motif DE_48h DE_48h-HOXA5_MA0158.2 8 bp overlap

HOXA6 1 dataset

Motif DE_48h DE_48h-HOXA6_MA1497.2 7 bp overlap

HOXA7 1 dataset

Motif DE_36h DE_36h-HOXA7_MA1498.3 6 bp overlap

HOXB1 1 dataset

Motif DE_48h DE_48h-HOXB1_MA2093.1 7 bp overlap

HOXB13 1 dataset

Motif DE_36h DE_36h-HOXB13_MA0901.3 9 bp overlap

HOXB2 1 dataset

Motif DE_48h DE_48h-HOXB2_MA0902.3 6 bp overlap

HOXB3 1 dataset

Motif DE_48h DE_48h-HOXB3_MA0903.2 6 bp overlap

HOXB5 1 dataset

Motif DE_48h DE_48h-HOXB5_MA0904.3 6 bp overlap

HOXB6 1 dataset

Motif DE_48h DE_48h-HOXB6_MA1500.2 7 bp overlap

HOXB7 1 dataset

Motif DE_48h DE_48h-HOXB7_MA1501.2 7 bp overlap

HOXB8 1 dataset

Motif DE_48h DE_48h-HOXB8_MA1502.2 7 bp overlap

HOXC8 1 dataset

Motif DE_48h DE_48h-HOXC8_MA1505.2 6 bp overlap

HOXD8 1 dataset

Motif DE_48h DE_48h-HOXD8_MA0910.3 7 bp overlap

Hmx1 1 dataset

Motif DE_36h DE_36h-Hmx1_MA0896.2 9 bp overlap

Hmx2 2 datasets

Motif DE_36h DE_36h-Hmx2_MA0897.2 15 bp overlap

Motif DE_48h DE_48h-Hmx2_MA0897.2 15 bp overlap

Hmx3 1 dataset

Motif DE_36h DE_36h-Hmx3_MA0898.2 9 bp overlap

ISX 1 dataset

Motif DE_48h DE_48h-ISX_MA0654.2 6 bp overlap

JUN 4 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 317 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 339 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 442 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 404 bp overlap

LBX2 1 dataset

Motif DE_36h DE_36h-LBX2_MA0699.2 6 bp overlap

LHX2 1 dataset

Motif DE_36h DE_36h-LHX2_MA0700.3 6 bp overlap

LHX5 1 dataset

Motif DE_48h DE_48h-LHX5_MA1519.2 7 bp overlap

LMO2 1 dataset

ChIP CCRF-CEM GSE33850.LMO2.CCRF-CEM 157 bp overlap

Lhx4 1 dataset

Motif DE_48h DE_48h-Lhx4_MA0704.2 6 bp overlap

Lhx8 1 dataset

Motif DE_48h DE_48h-Lhx8_MA0705.2 6 bp overlap

MEOX1 1 dataset

Motif DE_48h DE_48h-MEOX1_MA0661.2 7 bp overlap

MEOX2 1 dataset

Motif DE_48h DE_48h-MEOX2_MA0706.2 7 bp overlap

MGA 1 dataset

Motif DE_36h DE_36h-MGA_MA0801.1 8 bp overlap

MIXL1 1 dataset

Motif DE_48h DE_48h-MIXL1_MA0662.2 6 bp overlap

MNX1 1 dataset

Motif DE_48h DE_48h-MNX1_MA0707.3 6 bp overlap

MSX1 1 dataset

Motif DE_36h DE_36h-MSX1_MA0666.3 6 bp overlap

MSX2 1 dataset

Motif DE_36h DE_36h-MSX2_MA0708.3 6 bp overlap

Msx3 1 dataset

Motif DE_36h DE_36h-Msx3_MA0709.2 6 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 277 bp overlap

NKX6-2 1 dataset

Motif DE_48h DE_48h-NKX6-2_MA0675.2 6 bp overlap

Nobox 1 dataset

Motif DE_36h DE_36h-Nobox_MA0125.2 6 bp overlap

PAX3 1 dataset

Motif DE_36h DE_36h-PAX3_MA0780.1 10 bp overlap

PDX1 1 dataset

Motif DE_48h DE_48h-PDX1_MA0132.3 6 bp overlap

PHOX2A 2 datasets

Motif DE_36h DE_36h-PHOX2A_MA0713.1 11 bp overlap

Motif DE_48h DE_48h-PHOX2A_MA0713.1 11 bp overlap

PHOX2B 4 datasets

ChIP CLB-Ga GSE90683.PHOX2B.CLB-Ga 414 bp overlap

Motif DE_36h DE_36h-PHOX2B_MA0681.3 12 bp overlap

Motif DE_48h DE_48h-PHOX2B_MA0681.3 12 bp overlap

POU6F1 1 dataset

Motif DE_48h DE_48h-POU6F1_MA0628.2 6 bp overlap

POU6F2 1 dataset

Motif DE_48h DE_48h-POU6F2_MA0793.2 9 bp overlap

PROP1 1 dataset

Motif DE_36h DE_36h-PROP1_MA0715.1 11 bp overlap

PRRX1 1 dataset

Motif DE_48h DE_48h-PRRX1_MA0716.2 6 bp overlap

Pax7 1 dataset

Motif DE_36h DE_36h-Pax7_MA0680.3 10 bp overlap

RAX 1 dataset

Motif DE_36h DE_36h-RAX_MA0718.2 6 bp overlap

RAX2 1 dataset

Motif DE_48h DE_48h-RAX2_MA0717.2 6 bp overlap

SCRT1 1 dataset

Motif DE_48h DE_48h-SCRT1_MA0743.3 10 bp overlap

SCRT2 1 dataset

Motif DE_48h DE_48h-SCRT2_MA0744.3 10 bp overlap

SHOX 1 dataset

Motif DE_48h DE_48h-SHOX_MA0630.2 6 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 338 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 385 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 366 bp overlap

SMAD2_3 2 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 320 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 529 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 322 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 396 bp overlap

Shox2 1 dataset

Motif DE_48h DE_48h-Shox2_MA0720.2 6 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 350 bp overlap

TBR1 1 dataset

Motif DE_36h DE_36h-TBR1_MA0802.2 9 bp overlap

TBX1 1 dataset

Motif DE_36h DE_36h-TBX1_MA0805.1 8 bp overlap

TBX15 1 dataset

Motif DE_36h DE_36h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_36h DE_36h-TBX18_MA1565.2 9 bp overlap

TBX2 2 datasets

Motif DE_36h DE_36h-TBX2_MA0688.2 9 bp overlap

ChIP Kelly GSE94822.TBX2.Kelly 241 bp overlap

TBX20 1 dataset

Motif DE_36h DE_36h-TBX20_MA0689.1 11 bp overlap

TBX21 1 dataset

Motif DE_36h DE_36h-TBX21_MA0690.3 10 bp overlap

TBX3 1 dataset

Motif DE_36h DE_36h-TBX3_MA1566.3 9 bp overlap

TBX5 1 dataset

Motif DE_36h DE_36h-TBX5_MA0807.1 8 bp overlap

TLX2 1 dataset

Motif DE_48h DE_48h-TLX2_MA1577.2 6 bp overlap

Tbx6 1 dataset

Motif DE_36h DE_36h-Tbx6_MA1567.3 9 bp overlap

UNCX 1 dataset

Motif DE_48h DE_48h-UNCX_MA0721.2 6 bp overlap

VAX2 1 dataset

Motif DE_48h DE_48h-VAX2_MA0723.3 6 bp overlap

Wt1 2 datasets

Motif DE_36h DE_36h-Wt1_MA1627.2 10 bp overlap

Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap

ZNF24 1 dataset

Motif DE_36h DE_36h-ZNF24_MA1124.1 13 bp overlap

ZNF652 1 dataset

Motif DE_48h DE_48h-ZNF652_MA1657.2 9 bp overlap