chr14:20,642,696–20,643,499

chr14 : 20,642,696 – 20,643,499

803 bp 52 TFs 10 linked genes

This 803 bp open chromatin element is linked to 10 target genes and is bound by 52 transcription factors.

Linked Genes

10 genes

Gene	Expression	Dist. to TSS	Distance	Link type
RNASE4		41.6 kb	Distal	Multiome
ANG		41.6 kb	Distal	Multiome
EGILA		64.1 kb	Distal	Multiome
RNASE1		159.8 kb	Distal	Multiome
PNP		173.6 kb	Distal	Multiome
PIP4P1		181.6 kb	Distal	Multiome
APEX1		187.8 kb	Distal	Multiome
OSGEP		188.0 kb	Distal	Multiome
TEP1		229.6 kb	Distal	Multiome
PARP2		299.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

52 transcription factors

ARID1B 2 datasets

ChIP K-562 ENCSR822CCM.ARID1B.K-562 234 bp overlap

ChIP K562 ENCFF938UXQ 169 bp overlap

CBFA2T2 2 datasets

ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 309 bp overlap

ChIP K562 ENCFF963TXY 254 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 329 bp overlap

ChIP K562 ENCFF673OEZ 415 bp overlap

CTBP1 1 dataset

ChIP K562 ENCFF403WPG 536 bp overlap

FIGLA 1 dataset

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

FOXA2 1 dataset

ChIP DE DE-FOXA2-1 394 bp overlap

GATA1 3 datasets

ChIP K-562 GSE107726.GATA1.K-562 240 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 159 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 201 bp overlap

GATA1::TAL1 2 datasets

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 1 dataset

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 531 bp overlap

ChIP DE DE-GATA4-2 706 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 532 bp overlap

ChIP DE DE-GATA6-2 803 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 514 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 630 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 496 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 691 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 556 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 489 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 558 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 517 bp overlap

Gata3 1 dataset

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

HDAC2 2 datasets

ChIP K-562 ENCSR893WSB.HDAC2.K-562 199 bp overlap

ChIP K562 ENCFF744ALD 421 bp overlap

Motif DE_60h DE_60h-IRF3_MA1418.2 17 bp overlap

ChIP K-562 GSE142227.LDB1.K-562 175 bp overlap

NCOR1 3 datasets

ChIP K-562 ENCSR798ILC.NCOR1.K-562 253 bp overlap

ChIP K562 ENCFF788MPU 421 bp overlap

ChIP K562 ENCFF866HRM 445 bp overlap

ChIP K562 ENCFF167YID 457 bp overlap

POU2F1::SOX2 1 dataset

Motif DE_60h DE_60h-POU2F1SOX2_MA1962.1 17 bp overlap

PRDM14 1 dataset

ChIP primordial-germ-cell-like-cell GSE138674.PRDM14.primordial-germ-cell-like-cell 464 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_60h DE_60h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

RREB1 1 dataset

Motif DE_60h DE_60h-RREB1_MA0073.2 19 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 573 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 350 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 354 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 333 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 750 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 803 bp overlap

SNAI3 1 dataset

Motif DE_60h DE_60h-SNAI3_MA1559.2 9 bp overlap

SOX10 1 dataset

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 727 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 692 bp overlap

Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap

ChIP K562 ENCFF059YCJ 437 bp overlap

Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap

ChIP K-562_NABUT GSE74999.SPI1.K-562_NABUT 109 bp overlap

STAT1 1 dataset

Motif DE_60h DE_60h-STAT1_MA0137.4 9 bp overlap

STAT3 1 dataset

Motif DE_60h DE_60h-STAT3_MA0144.3 9 bp overlap

Sox11 1 dataset

Motif DE_60h DE_60h-Sox11_MA0869.3 8 bp overlap

Stat4 1 dataset

Motif DE_60h DE_60h-Stat4_MA0518.2 10 bp overlap

TAL1 10 datasets

ChIP K-562 GSE107726.TAL1.K-562 439 bp overlap

ChIP K-562 ENCSR000EHB.TAL1.K-562 188 bp overlap

ChIP K-562_dCas9-KRAB GSE132212.TAL1.K-562_dCas9-KRAB 231 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 216 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 216 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 219 bp overlap

ChIP K-562_sgGal4 GSE132212.TAL1.K-562_sgGal4 177 bp overlap

ChIP K562 ENCFF620GMX 184 bp overlap

ChIP K562 ENCFF661CCK 277 bp overlap

ChIP ProEs GSE59087.TAL1.ProEs 221 bp overlap

TCF12 2 datasets

ChIP K-562 ENCSR744WOO.TCF12.K-562 225 bp overlap

ChIP K562 ENCFF931DJY 142 bp overlap

TCF3 2 datasets

ChIP K-562 ENCSR970OJY.TCF3.K-562 199 bp overlap

ChIP K562 ENCFF319QZT 381 bp overlap

TCF7L2 1 dataset

Motif DE_60h DE_60h-TCF7L2_MA0523.2 9 bp overlap

TRPS1 1 dataset

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-Wt1_MA1627.2 10 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

ZNF184 1 dataset

Motif DE_60h DE_60h-ZNF184_MA2120.1 13 bp overlap

ZNF189 1 dataset

Motif DE_60h DE_60h-ZNF189_MA1725.2 9 bp overlap

ZNF281 1 dataset

ChIP K562 ENCFF594VNM 471 bp overlap

ZNF341 1 dataset

ChIP HEK293 ENCFF944VMC 443 bp overlap

ZNF418 1 dataset

Motif DE_60h DE_60h-ZNF418_MA1980.1 15 bp overlap

ZNF460 1 dataset

Motif DE_60h DE_60h-ZNF460_MA1596.1 16 bp overlap

ZNF677 1 dataset

Motif DE_60h DE_60h-ZNF677_MA2101.1 12 bp overlap

ZNF75D 1 dataset

Motif DE_60h DE_60h-ZNF75D_MA1601.2 12 bp overlap

Zfp335 1 dataset

Motif DE_60h DE_60h-Zfp335_MA2002.2 7 bp overlap