This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PARP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:20,332,742–20,333,665 | 10.4 kb | Distal (>10kb) Multiome | 694 | |
| chr14:20,342,187–20,344,100 | 266 bp | At TSS Multiome | 1112 | |
| chr14:20,412,688–20,413,758 | 69.7 kb | Distal (>10kb) Multiome | 865 | |
| chr14:20,454,384–20,455,825 | 111.5 kb | Distal (>10kb) Multiome | 1012 | |
| chr14:20,460,777–20,462,259 | 118.0 kb | Distal (>10kb) Multiome | 995 | |
| chr14:20,468,846–20,470,856 | 125.8 kb | Distal (>10kb) Multiome | 950 | |
| chr14:20,494,584–20,495,486 | 151.4 kb | Distal (>10kb) Multiome | 201 | |
| chr14:20,609,147–20,610,547 | 266.5 kb | Distal (>10kb) Multiome HiCAR | 852 | |
| chr14:20,612,915–20,614,464 | 270.1 kb | Distal (>10kb) Multiome | 1003 | |
| chr14:20,624,684–20,626,122 | 281.8 kb | Distal (>10kb) Multiome | 728 | |
| chr14:20,630,325–20,631,286 | 287.1 kb | Distal (>10kb) Multiome | 507 | |
| chr14:20,631,700–20,633,862 | 289.6 kb | Distal (>10kb) Multiome | 757 | |
| chr14:20,642,696–20,643,499 | 299.4 kb | Distal (>10kb) Multiome | 52 |
Genomic view of the PARP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.