chr6:158,773,639–158,774,564

chr6 : 158,773,639 – 158,774,564

925 bp 55 TFs 5 linked genes

This 925 bp open chromatin element is linked to 5 target genes and is bound by 55 transcription factors.

Linked Genes

5 genes

Gene	Expression	Dist. to TSS	Distance	Link type
EZR		45.2 kb	Distal	Multiome
DYNLT1		129.4 kb	Distal	Multiome
TMEM181		214.0 kb	Distal	Multiome
TAGAP-AS1		225.8 kb	Distal	Multiome+HiCAR
RSPH3		226.0 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

55 transcription factors

ChIP HCT-116 GSE103894.APC.HCT-116 925 bp overlap

BACH1 1 dataset

ChIP GM12878 ENCSR636MKU.BACH1.GM12878 179 bp overlap

BRD1 2 datasets

ChIP HUES-64 GSE104059.BRD1.HUES-64 121 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 270 bp overlap

BRD4 2 datasets

ChIP COLO-741 GSE73319.BRD4.COLO-741 355 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 188 bp overlap

ChIP HCT-116_KAP1-KO GSE132705.CDK9.HCT-116_KAP1-KO 843 bp overlap

CDKN1B 1 dataset

ChIP MDA-MB-231_p27CK-DD GSE112444.CDKN1B.MDA-MB-231_p27CK-DD 270 bp overlap

DNMT3B 2 datasets

ChIP HUES-8_TripleKO-TET1-2-3 GSE99346.DNMT3B.HUES-8_TripleKO-TET1-2-3 242 bp overlap

ChIP HUES-8_TripleKO-TET1-2-3 GSE99346.DNMT3B.HUES-8_TripleKO-TET1-2-3 211 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 259 bp overlap

ChIP hESC GSE26097.EOMES.hESC 187 bp overlap

ESR1 5 datasets

ChIP MCF-7_E2-5min-ERalpha GSE94023.ESR1.MCF-7_E2-5min-ERalpha 181 bp overlap

ChIP MCF-7_Tamoxifen GSE102410.ESR1.MCF-7_Tamoxifen 173 bp overlap

ChIP MCF-7_estradiol-DHT_4h GSE99626.ESR1.MCF-7_estradiol-DHT_4h 180 bp overlap

ChIP MCF-7_jc5853 GSE126004.ESR1.MCF-7_jc5853 235 bp overlap

ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.ESR1.MCF-7_parental_4-hydroxytamoxifen 154 bp overlap

ESR1_pS118 2 datasets

ChIP MCF-7_Veh_sc GSE117569.ESR1_pS118.MCF-7_Veh_sc 58 bp overlap

ChIP MCF-7_Veh_sc GSE117569.ESR1_pS118.MCF-7_Veh_sc 255 bp overlap

FOXA1 1 dataset

ChIP LS180 GSE140533.FOXA1.LS180 76 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 728 bp overlap

ChIP DE DE-FOXA2-2 732 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 612 bp overlap

ChIP DE DE-GATA4-2 709 bp overlap

ChIP foregut GSE117136.GATA4.foregut 314 bp overlap

GATA6 12 datasets

ChIP DE DE-GATA6-1 551 bp overlap

ChIP DE DE-GATA6-2 560 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 681 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 680 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 760 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 576 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 845 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 788 bp overlap

ChIP OACP4-C GSE132680.GATA6.OACP4-C 342 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 753 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 303 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 294 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 304 bp overlap

HOXB13 3 datasets

ChIP prostate-cancer_PDX_189-4 GSE130408.HOXB13.prostate-cancer_PDX_189-4 262 bp overlap

ChIP prostate-cancer_PDX_70 GSE130408.HOXB13.prostate-cancer_PDX_70 64 bp overlap

ChIP prostate_P7_T GSE130408.HOXB13.prostate_P7_T 212 bp overlap

Motif DE_48h DE_48h-JDP2_MA0655.1 9 bp overlap

ChIP 786-O GSE86092.JUN.786-O 397 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 532 bp overlap

JUNB 2 datasets

ChIP Karpas-299 GSE151413.JUNB.Karpas-299 358 bp overlap

ChIP Karpas-299 GSE151413.JUNB.Karpas-299 400 bp overlap

JUND 2 datasets

ChIP A-549 ENCSR000BRF.JUND.A-549 118 bp overlap

ChIP HCT-116 ENCSR000BSA.JUND.HCT-116 130 bp overlap

ChIP PDAC GSE64557.KLF6.PDAC 246 bp overlap

MITF 4 datasets

ChIP 501-mel GSE137522.MITF.501-mel 288 bp overlap

ChIP 501-mel_20ng_K243R GSE137522.MITF.501-mel_20ng_K243R 274 bp overlap

ChIP 501-mel_K243Q GSE137522.MITF.501-mel_K243Q 268 bp overlap

ChIP melanocyte_CTR GSE50681.MITF.melanocyte_CTR 400 bp overlap

NFATC1 1 dataset

ChIP GM12878 ENCSR000BQL.NFATC1.GM12878 299 bp overlap

Motif DE_48h DE_48h-NFE2_MA0841.2 10 bp overlap

PHIP 3 datasets

ChIP HCT-116_MLL1-KO__ab833 GSE101646.PHIP.HCT-116_MLL1-KO__ab833 747 bp overlap

ChIP HCT-116_ab833 GSE101646.PHIP.HCT-116_ab833 145 bp overlap

ChIP HCT-116_ab833 GSE101646.PHIP.HCT-116_ab833 370 bp overlap

POLR2A 15 datasets

ChIP GM12878 ENCFF521FXC 221 bp overlap

ChIP GM12891 ENCFF127ICP 511 bp overlap

ChIP GM12891 ENCFF379FCI 501 bp overlap

ChIP GM12892 ENCFF506PGQ 477 bp overlap

ChIP GM18526 ENCFF599EPS 252 bp overlap

ChIP GM18526 ENCFF599EPS 431 bp overlap

ChIP GM19193 ENCFF599VTO 525 bp overlap

ChIP HCT116 ENCFF508RDJ 400 bp overlap

ChIP HCT116 ENCFF508RDJ 351 bp overlap

ChIP HeLa-S3 ENCFF773DNG 541 bp overlap

ChIP spleen ENCFF706IUS 251 bp overlap

ChIP transverse colon ENCFF607LKE 269 bp overlap

ChIP transverse colon ENCFF607LKE 371 bp overlap

ChIP transverse colon ENCFF610RWV 425 bp overlap

ChIP transverse colon ENCFF610RWV 274 bp overlap

POLR2G 1 dataset

ChIP K562 ENCFF047BLG 398 bp overlap

POU5F1 2 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 685 bp overlap

ChIP SKM-1 GSE93706.POU5F1.SKM-1 313 bp overlap

RAD21 1 dataset

ChIP HCT-116 GSE131606.RAD21.HCT-116 238 bp overlap

RBM22 2 datasets

ChIP K-562 GSE120104.RBM22.K-562 303 bp overlap

ChIP K-562 ENCSR848AOP.RBM22.K-562 303 bp overlap

RPA2_phospho 1 dataset

ChIP HeLa_shTOP1 GSE108172.RPA2_phospho.HeLa_shTOP1 232 bp overlap

ChIP HEK GSE73865.SIX2.HEK 168 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 558 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 750 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 506 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 335 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 465 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 340 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 722 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 536 bp overlap

SMAD4 1 dataset

ChIP Caco-2 GSE112946.SMAD4.Caco-2 150 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 362 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 457 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 321 bp overlap

ChIP HCT-116 GSE131606.SMC1.HCT-116 219 bp overlap

SOX10 1 dataset

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 299 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 397 bp overlap

Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap

SREBF2 1 dataset

Motif DE_48h DE_48h-SREBF2_MA0596.1 10 bp overlap

SUPT5H 2 datasets

ChIP DLD-1_NELFCD-AID_treated GSE144786.SUPT5H.DLD-1_NELFCD-AID_treated 51 bp overlap

ChIP HCT-116_DMSO_pSer666 GSE138548.SUPT5H.HCT-116_DMSO_pSer666 296 bp overlap

Sox11 1 dataset

Motif DE_48h DE_48h-Sox11_MA0869.3 8 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 148 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 230 bp overlap

USF1 2 datasets

ChIP H1 ENCFF090WVU 211 bp overlap

ChIP WA01 ENCSR000BIU.USF1.WA01 224 bp overlap

ChIP WTC11 ENCFF139JAW 293 bp overlap

Motif DE_48h DE_48h-Vdr_MA0693.4 7 bp overlap

XRCC5 2 datasets

ChIP K-562 GSE120104.XRCC5.K-562 175 bp overlap

ChIP K-562 ENCSR506KWJ.XRCC5.K-562 159 bp overlap

ZC3H8 1 dataset

ChIP HCT-116 GSE47938.ZC3H8.HCT-116 270 bp overlap

Motif DE_48h DE_48h-ZIM3_MA1709.2 11 bp overlap

ZNF274 1 dataset

Motif DE_48h DE_48h-ZNF274_MA1592.2 12 bp overlap

ZNF317 1 dataset

Motif DE_48h DE_48h-ZNF317_MA1593.2 8 bp overlap

ZNF652 2 datasets

ChIP Hep-G2 ENCSR502GAX.ZNF652.Hep-G2 267 bp overlap

ChIP HepG2 ENCFF331VPZ 337 bp overlap