The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EZR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EZR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EZR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:158,535,948–158,537,835 | 282.1 kb | Distal (>10kb) Multiome | 995 | |
| chr6:158,559,760–158,560,738 | 259.3 kb | Distal (>10kb) Multiome | 865 | |
| chr6:158,611,556–158,612,449 | 207.5 kb | Distal (>10kb) Multiome | 166 | |
| chr6:158,644,121–158,645,373 | 174.6 kb | Distal (>10kb) Multiome | 959 | |
| chr6:158,704,230–158,704,856 | 115.0 kb | Distal (>10kb) Multiome | 886 | |
| chr6:158,706,215–158,706,876 | 113.0 kb | Distal (>10kb) Multiome | 190 | |
| chr6:158,707,164–158,707,736 | 111.9 kb | Distal (>10kb) Multiome | 295 | |
| chr6:158,718,163–158,718,988 | 100.7 kb | Distal (>10kb) Multiome | 244 | |
| chr6:158,773,639–158,774,564 | 45.2 kb | Distal (>10kb) Multiome | 55 | |
| chr6:158,817,287–158,819,780 | 1.1 kb | Proximal (<10kb) Multiome | 1077 | |
| chr6:158,835,350–158,835,822 | 16.3 kb | Distal (>10kb) Multiome | 212 | |
| chr6:158,853,179–158,854,186 | 34.1 kb | Distal (>10kb) Multiome | 879 | |
| chr6:158,869,125–158,870,412 | 50.4 kb | Distal (>10kb) Multiome | 808 | |
| chr6:158,878,392–158,879,559 | 59.5 kb | Distal (>10kb) Multiome | 84 | |
| chr6:158,910,515–158,910,986 | 91.4 kb | Distal (>10kb) Multiome | 244 | |
| chr6:158,999,160–159,000,539 | 180.6 kb | Distal (>10kb) Multiome | 1122 | |
| chr6:159,103,945–159,104,600 | 284.9 kb | Distal (>10kb) Multiome | 318 |
Genomic view of the EZR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.