This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for DYNLT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNLT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNLT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:158,464,343–158,464,804 | 180.1 kb | Distal (>10kb) Multiome | 90 | |
| chr6:158,467,569–158,468,415 | 176.7 kb | Distal (>10kb) Multiome | 239 | |
| chr6:158,535,948–158,537,835 | 107.5 kb | Distal (>10kb) Multiome | 995 | |
| chr6:158,559,760–158,560,738 | 84.6 kb | Distal (>10kb) Multiome | 865 | |
| chr6:158,611,556–158,612,449 | 32.9 kb | Distal (>10kb) Multiome | 166 | |
| chr6:158,635,533–158,636,011 | 8.7 kb | Proximal (<10kb) | 29 | |
| chr6:158,644,121–158,645,373 | 48 bp | At TSS Multiome | 959 | |
| chr6:158,704,230–158,704,856 | 59.6 kb | Distal (>10kb) Multiome | 886 | |
| chr6:158,706,215–158,706,876 | 61.7 kb | Distal (>10kb) Multiome | 190 | |
| chr6:158,707,164–158,707,736 | 62.7 kb | Distal (>10kb) Multiome | 295 | |
| chr6:158,718,163–158,718,988 | 73.9 kb | Distal (>10kb) Multiome | 244 | |
| chr6:158,773,639–158,774,564 | 129.4 kb | Distal (>10kb) Multiome | 55 | |
| chr6:158,817,287–158,819,780 | 173.5 kb | Distal (>10kb) Multiome | 1077 | |
| chr6:158,835,350–158,835,822 | 191.0 kb | Distal (>10kb) Multiome | 212 | |
| chr6:158,853,179–158,854,186 | 208.7 kb | Distal (>10kb) Multiome | 879 | |
| chr6:158,869,125–158,870,412 | 225.0 kb | Distal (>10kb) Multiome | 808 | |
| chr6:158,878,392–158,879,559 | 234.1 kb | Distal (>10kb) Multiome | 84 | |
| chr6:158,910,515–158,910,986 | 266.0 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the DYNLT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.