The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
Transcription factors with Perturb-seq knockdown data for TMEM181. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM181 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM181, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:158,339,091–158,339,595 | 220.7 kb | Distal (>10kb) Multiome | 264 | |
| chr6:158,464,343–158,464,804 | 95.4 kb | Distal (>10kb) Multiome | 90 | |
| chr6:158,467,569–158,468,415 | 92.0 kb | Distal (>10kb) Multiome | 239 | |
| chr6:158,535,948–158,537,835 | 22.9 kb | Distal (>10kb) Multiome | 995 | |
| chr6:158,552,483–158,552,778 | 7.3 kb | Proximal (<10kb) | 113 | |
| chr6:158,559,760–158,560,738 | 13 bp | At TSS Multiome | 865 | |
| chr6:158,611,556–158,612,449 | 51.8 kb | Distal (>10kb) Multiome | 166 | |
| chr6:158,644,121–158,645,373 | 84.7 kb | Distal (>10kb) Multiome | 959 | |
| chr6:158,704,230–158,704,856 | 144.3 kb | Distal (>10kb) Multiome | 886 | |
| chr6:158,706,215–158,706,876 | 146.3 kb | Distal (>10kb) Multiome | 190 | |
| chr6:158,707,164–158,707,736 | 147.4 kb | Distal (>10kb) Multiome | 295 | |
| chr6:158,718,163–158,718,988 | 158.5 kb | Distal (>10kb) Multiome | 244 | |
| chr6:158,773,639–158,774,564 | 214.0 kb | Distal (>10kb) Multiome | 55 | |
| chr6:158,817,287–158,819,780 | 258.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr6:158,835,350–158,835,822 | 275.6 kb | Distal (>10kb) Multiome | 212 | |
| chr6:158,853,179–158,854,186 | 293.4 kb | Distal (>10kb) Multiome | 879 |
Genomic view of the TMEM181 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.