chr21 : 38,814,194 – 38,814,445

251 bp 71 TFs 1 linked gene

This 251 bp open chromatin element is linked to ETS2 and is bound by 71 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
ETS2		8.3 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

71 transcription factors

ATRX 1 dataset

ChIP metastatic-neuroblastoma_CHLA90 GSE100148.ATRX.metastatic-neuroblastoma_CHLA90 201 bp overlap

Atf3 1 dataset

Motif DE_12h DE_12h-Atf3_MA1988.2 7 bp overlap

BACH1 1 dataset

Motif DE_12h DE_12h-BACH1_MA1633.2 9 bp overlap

BACH2 1 dataset

Motif DE_12h DE_12h-BACH2_MA1101.3 11 bp overlap

BATF 1 dataset

Motif DE_12h DE_12h-BATF_MA1634.2 7 bp overlap

BATF3 1 dataset

Motif DE_12h DE_12h-BATF3_MA0835.3 7 bp overlap

BATF::JUN 1 dataset

Motif DE_12h DE_12h-BATFJUN_MA0462.3 7 bp overlap

BCOR 1 dataset

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 219 bp overlap

BNC2 1 dataset

Motif DE_12h DE_12h-BNC2_MA1928.2 7 bp overlap

BRD4 2 datasets

ChIP HCT-15 GSE73319.BRD4.HCT-15 148 bp overlap

ChIP HeLa_JQ1 GSE151038.BRD4.HeLa_JQ1 113 bp overlap

CTCF 1 dataset

Motif DE_12h DE_12h-CTCF_MA1930.2 33 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 154 bp overlap

FLI1 1 dataset

ChIP A-673_1_KRAB_GFP GSE106914.FLI1.A-673_1_KRAB_GFP 251 bp overlap

FOS 1 dataset

Motif DE_12h DE_12h-FOS_MA0476.2 8 bp overlap

FOS::JUN 1 dataset

Motif DE_12h DE_12h-FOSJUN_MA0099.4 9 bp overlap

FOS::JUNB 1 dataset

Motif DE_12h DE_12h-FOSJUNB_MA1134.2 9 bp overlap

FOS::JUND 1 dataset

Motif DE_12h DE_12h-FOSJUND_MA1141.2 9 bp overlap

FOSL1 1 dataset

Motif DE_12h DE_12h-FOSL1_MA0477.3 9 bp overlap

FOSL1::JUN 1 dataset

Motif DE_12h DE_12h-FOSL1JUN_MA1128.2 9 bp overlap

FOSL1::JUNB 1 dataset

Motif DE_12h DE_12h-FOSL1JUNB_MA1137.2 9 bp overlap

FOSL1::JUND 1 dataset

Motif DE_12h DE_12h-FOSL1JUND_MA1142.2 8 bp overlap

FOXA2 1 dataset

ChIP DE DE-FOXA2-2 223 bp overlap

GATA4 1 dataset

ChIP DE DE-GATA4-2 251 bp overlap

GATA6 6 datasets

ChIP DE DE-GATA6-2 251 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 241 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 251 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 251 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 216 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 251 bp overlap

GLYR1 1 dataset

ChIP HeLa GSE20303.GLYR1.HeLa 223 bp overlap

HIC2 1 dataset

Motif DE_12h DE_12h-HIC2_MA0738.2 6 bp overlap

IKZF1 1 dataset

Motif DE_12h DE_12h-IKZF1_MA1508.2 8 bp overlap

IRF2 1 dataset

ChIP keratinocyte_DOX GSE135677.IRF2.keratinocyte_DOX 124 bp overlap

JDP2 1 dataset

Motif DE_12h DE_12h-JDP2_MA0655.1 9 bp overlap

JUN 6 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 251 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 251 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 251 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 251 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 251 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 251 bp overlap

JUNB 2 datasets

Motif DE_12h DE_12h-JUNB_MA0490.3 9 bp overlap

ChIP Karpas-299 GSE151413.JUNB.Karpas-299 156 bp overlap

JUND 2 datasets

Motif DE_12h DE_12h-JUND_MA0491.3 9 bp overlap

ChIP WA01 ENCSR000EBZ.JUND.WA01 190 bp overlap

Jun 1 dataset

Motif DE_12h DE_12h-Jun_MA0489.3 8 bp overlap

KLF4 1 dataset

ChIP foreskin GSE126390.KLF4.foreskin 246 bp overlap

MAF::NFE2 1 dataset

Motif DE_12h DE_12h-MAFNFE2_MA0501.2 11 bp overlap

MAFG::NFE2L1 1 dataset

Motif DE_12h DE_12h-MAFGNFE2L1_MA0089.3 11 bp overlap

MAFK 1 dataset

Motif DE_12h DE_12h-MAFK_MA0496.4 10 bp overlap

MLLT1_FKB 1 dataset

ChIP MV4-11 GSE82116.MLLT1_FKB.MV4-11 132 bp overlap

MYCN 1 dataset

ChIP MYCN-3_low GSE83317.MYCN.MYCN-3_low 124 bp overlap

MYOD1 1 dataset

ChIP RD_shSNAI2 GSE137168.MYOD1.RD_shSNAI2 136 bp overlap

Mafg 1 dataset

Motif DE_12h DE_12h-Mafg_MA0659.4 12 bp overlap

NANOG 3 datasets

ChIP WA01 ENCSR000BMT.NANOG.WA01 117 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 251 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 251 bp overlap

NCAPH2 1 dataset

ChIP IMR-90_FLAG_OIS GSE118494.NCAPH2.IMR-90_FLAG_OIS 223 bp overlap

NFE2 1 dataset

Motif DE_12h DE_12h-NFE2_MA0841.2 10 bp overlap

POLR2A 7 datasets

ChIP HL-60 ENCFF321XKE 64 bp overlap

ChIP HepG2 ENCFF718XAJ 151 bp overlap

ChIP sigmoid colon ENCFF725QFT 122 bp overlap

ChIP sigmoid colon ENCFF748YVT 136 bp overlap

ChIP sigmoid colon ENCFF754JQR 55 bp overlap

ChIP transverse colon ENCFF607LKE 112 bp overlap

ChIP transverse colon ENCFF610RWV 74 bp overlap

REL 1 dataset

Motif DE_12h DE_12h-REL_MA0101.1 10 bp overlap

RELA 1 dataset

Motif DE_12h DE_12h-RELA_MA0107.1 10 bp overlap

RPA2_phospho 2 datasets

ChIP HeLa GSE108172.RPA2_phospho.HeLa 202 bp overlap

ChIP HeLa_shTOP1 GSE108172.RPA2_phospho.HeLa_shTOP1 59 bp overlap

SMAD2 3 datasets

ChIP hESC GSE29422.SMAD2.hESC 186 bp overlap

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 251 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 251 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 251 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 251 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 251 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 251 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 251 bp overlap

SMAD3 1 dataset

ChIP hESC GSE29422.SMAD3.hESC 157 bp overlap

SMARCA4 2 datasets

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 230 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 251 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 251 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 242 bp overlap

SMARCC1 2 datasets

ChIP hiPSC GSE124903.SMARCC1.hiPSC 251 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 251 bp overlap

SPIC 1 dataset

Motif DE_12h DE_12h-SPIC_MA0687.2 13 bp overlap

SUPT5H 1 dataset

ChIP DLD-1_NELFCD-AID GSE144786.SUPT5H.DLD-1_NELFCD-AID 150 bp overlap

Spi1 2 datasets

Motif DE_12h DE_12h-Spi1_MA0080.7 13 bp overlap

T 2 datasets

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 204 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 200 bp overlap

TCF7L2 1 dataset

ChIP LNCaP GSE51621.TCF7L2.LNCaP 129 bp overlap

TEAD1 1 dataset

Motif DE_12h DE_12h-TEAD1_MA0090.4 9 bp overlap

TEAD3 1 dataset

Motif DE_12h DE_12h-TEAD3_MA0808.1 8 bp overlap

TEAD4 1 dataset

Motif DE_12h DE_12h-TEAD4_MA0809.3 8 bp overlap

TP63 1 dataset

ChIP foreskin GSE126390.TP63.foreskin 218 bp overlap

TRIM28 1 dataset

ChIP hESC GSE115387.TRIM28.hESC 187 bp overlap

U2AF1 1 dataset

ChIP Hep-G2 GSE120104.U2AF1.Hep-G2 167 bp overlap

ZFP14 1 dataset

Motif DE_12h DE_12h-ZFP14_MA1972.1 15 bp overlap

ZNF189 1 dataset

Motif DE_12h DE_12h-ZNF189_MA1725.2 9 bp overlap

ZNF652 1 dataset

ChIP Hep-G2 ENCSR502GAX.ZNF652.Hep-G2 250 bp overlap

ZNF677 1 dataset

Motif DE_12h DE_12h-ZNF677_MA2101.1 12 bp overlap

ZNF708 1 dataset

Motif DE_12h DE_12h-ZNF708_MA1730.2 9 bp overlap

ZSCAN31 1 dataset

Motif DE_12h DE_12h-ZSCAN31_MA1722.2 18 bp overlap