chr10 : 113,572,599 – 113,573,340

741 bp 68 TFs 3 linked genes

This 741 bp open chromatin element is linked to CASP7, DCLRE1A, and NHLRC2 and is bound by 68 transcription factors.

Linked Genes

3 genes

Gene	Dist. to TSS	Distance	Link type
CASP7	106.2 kb	Distal	Multiome
DCLRE1A	281.4 kb	Distal	Multiome
NHLRC2	281.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

68 transcription factors

ATF2 1 dataset

ChIP WA01 ENCSR000BQU.ATF2.WA01 134 bp overlap

BCOR 1 dataset

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 149 bp overlap

BHLHE22 2 datasets

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

BRF1 1 dataset

ChIP H9_Activin GSE94418.BRF1.H9_Activin 148 bp overlap

Bcl11B 3 datasets

Motif DE_48h DE_48h-Bcl11B_MA1989.2 9 bp overlap

Motif DE_60h DE_60h-Bcl11B_MA1989.2 9 bp overlap

Motif DE_72h DE_72h-Bcl11B_MA1989.2 9 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 191 bp overlap

ChIP hESC GSE26097.EOMES.hESC 348 bp overlap

ERF::FIGLA 3 datasets

Motif DE_48h DE_48h-ERFFIGLA_MA1934.2 13 bp overlap

Motif DE_60h DE_60h-ERFFIGLA_MA1934.2 13 bp overlap

ESR1 2 datasets

ChIP breast-cancer_3487 GSE126004.ESR1.breast-cancer_3487 257 bp overlap

ChIP endometrioid-adenocarcinoma_tumor_F GSE94031.ESR1.endometrioid-adenocarcinoma_tumor_F 198 bp overlap

ETV2::FIGLA 2 datasets

Motif DE_48h DE_48h-ETV2FIGLA_MA1941.2 13 bp overlap

Motif DE_60h DE_60h-ETV2FIGLA_MA1941.2 13 bp overlap

ETV5::FIGLA 3 datasets

Motif DE_48h DE_48h-ETV5FIGLA_MA1945.2 14 bp overlap

Motif DE_60h DE_60h-ETV5FIGLA_MA1945.2 14 bp overlap

EZH2 3 datasets

ChIP A-1847_CARM1-KO GSE95643.EZH2.A-1847_CARM1-KO 741 bp overlap

ChIP HCT-116 ENCSR046HGP.EZH2.HCT-116 102 bp overlap

ChIP PC-9 ENCSR793USK.EZH2.PC-9 281 bp overlap

FEZF1 1 dataset

ChIP HEK293 ENCSR827NWO.FEZF1.HEK293 415 bp overlap

FOXA1 1 dataset

ChIP breast-cancer_3487 GSE126004.FOXA1.breast-cancer_3487 205 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 579 bp overlap

ChIP DE DE-FOXA2-2 627 bp overlap

GATA2 2 datasets

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 210 bp overlap

GATA4 8 datasets

ChIP DE DE-GATA4-1 675 bp overlap

ChIP DE DE-GATA4-2 741 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 706 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 514 bp overlap

GATA5 1 dataset

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

GATA6 14 datasets

ChIP DE DE-GATA6-1 741 bp overlap

ChIP DE DE-GATA6-2 741 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 634 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 614 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 520 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 686 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 639 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 649 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 669 bp overlap

ChIP foregut GSE117136.GATA6.foregut 674 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 633 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 460 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 465 bp overlap

Gata3 1 dataset

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

HOXB4 2 datasets

Motif DE_48h DE_48h-HOXB4_MA1499.2 6 bp overlap

Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap

HOXC4 2 datasets

Motif DE_48h DE_48h-HOXC4_MA1504.2 6 bp overlap

Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap

HOXD4 2 datasets

Motif DE_48h DE_48h-HOXD4_MA1507.2 6 bp overlap

Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap

MED1 1 dataset

ChIP dopaminergic-neuron_Dopamine_neurons GSE93905.MED1.dopaminergic-neuron_Dopamine_neurons 139 bp overlap

MTF2 1 dataset

ChIP DU145_SH4 GSE135623.MTF2.DU145_SH4 201 bp overlap

NKX6-3 2 datasets

Motif DE_48h DE_48h-NKX6-3_MA1530.2 8 bp overlap

Motif DE_60h DE_60h-NKX6-3_MA1530.2 8 bp overlap

Neurod2 2 datasets

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Olig2 2 datasets

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

PDX1 3 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 360 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 150 bp overlap

ChIP islet ERP001456.PDX1.islet 147 bp overlap

PHF19 1 dataset

ChIP DU145_CTR GSE135623.PHF19.DU145_CTR 239 bp overlap

POU1F1 2 datasets

Motif DE_48h DE_48h-POU1F1_MA0784.3 14 bp overlap

Motif DE_60h DE_60h-POU1F1_MA0784.3 14 bp overlap

POU2F2 2 datasets

Motif DE_48h DE_48h-POU2F2_MA0507.3 13 bp overlap

Motif DE_60h DE_60h-POU2F2_MA0507.3 13 bp overlap

POU3F1 2 datasets

Motif DE_48h DE_48h-POU3F1_MA0786.2 10 bp overlap

Motif DE_60h DE_60h-POU3F1_MA0786.2 10 bp overlap

POU3F2 2 datasets

Motif DE_48h DE_48h-POU3F2_MA0787.1 12 bp overlap

Motif DE_60h DE_60h-POU3F2_MA0787.1 12 bp overlap

POU3F4 2 datasets

Motif DE_48h DE_48h-POU3F4_MA0789.1 9 bp overlap

Motif DE_60h DE_60h-POU3F4_MA0789.1 9 bp overlap

POU5F1 2 datasets

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 322 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 187 bp overlap

POU6F1 2 datasets

Motif DE_48h DE_48h-POU6F1_MA1549.2 7 bp overlap

Motif DE_60h DE_60h-POU6F1_MA1549.2 7 bp overlap

POU6F2 2 datasets

Motif DE_48h DE_48h-POU6F2_MA0793.2 9 bp overlap

Motif DE_60h DE_60h-POU6F2_MA0793.2 9 bp overlap

PRDM6 3 datasets

ChIP HEK293 ENCFF283AJL 197 bp overlap

ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 293 bp overlap

ChIP HEK293 GSE76494.PRDM6.HEK293 153 bp overlap

Pgr 1 dataset

Motif DE_60h DE_60h-Pgr_MA2323.1 17 bp overlap

RARA::RXRA 1 dataset

Motif DE_60h DE_60h-RARARXRA_MA0159.1 17 bp overlap

RARA::RXRG 1 dataset

Motif DE_60h DE_60h-RARARXRG_MA1149.2 17 bp overlap

REST 1 dataset

ChIP colorectal-cancer_shCDH1 GSE112555.REST.colorectal-cancer_shCDH1 68 bp overlap

SMAD2 2 datasets

ChIP endoderm GSE29422.SMAD2.endoderm 133 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 251 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 644 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 655 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 612 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 156 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 251 bp overlap

SMARCC1 1 dataset

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 181 bp overlap

SOX13 1 dataset

Motif DE_60h DE_60h-SOX13_MA1120.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 566 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 633 bp overlap

SOX2 1 dataset

Motif DE_60h DE_60h-SOX2_MA0143.5 7 bp overlap

STAT3 1 dataset

ChIP breast-cancer_3487 GSE126004.STAT3.breast-cancer_3487 234 bp overlap

Sox17 1 dataset

Motif DE_60h DE_60h-Sox17_MA0078.3 10 bp overlap

Sox3 1 dataset

Motif DE_60h DE_60h-Sox3_MA0514.3 7 bp overlap

Sox5 1 dataset

Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap

Sox6 1 dataset

Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap

Sox7 1 dataset

Motif DE_60h DE_60h-Sox7_MA2095.1 10 bp overlap

TFAP4 2 datasets

Motif DE_48h DE_48h-TFAP4_MA0691.1 10 bp overlap

Motif DE_60h DE_60h-TFAP4_MA0691.1 10 bp overlap

TFAP4::ETV1 2 datasets

Motif DE_48h DE_48h-TFAP4ETV1_MA1966.2 13 bp overlap

Motif DE_60h DE_60h-TFAP4ETV1_MA1966.2 13 bp overlap

TFAP4::FLI1 2 datasets

Motif DE_48h DE_48h-TFAP4FLI1_MA1967.2 14 bp overlap

Motif DE_60h DE_60h-TFAP4FLI1_MA1967.2 14 bp overlap

TRIM28 1 dataset

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 236 bp overlap

TRPS1 1 dataset

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Tcf12 2 datasets

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Twist2 2 datasets

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

ZBTB8A 1 dataset

ChIP HEK293 ENCSR481FEC.ZBTB8A.HEK293 267 bp overlap

ZNF257 1 dataset

ChIP HEK293T GSE78099.ZNF257.HEK293T 62 bp overlap

ZNF768 1 dataset

Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap