This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for DCLRE1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCLRE1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCLRE1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:113,555,598–113,556,217 | 298.4 kb | Distal (>10kb) Multiome | 129 | |
| chr10:113,563,298–113,563,961 | 290.7 kb | Distal (>10kb) Multiome | 379 | |
| chr10:113,572,599–113,573,340 | 281.4 kb | Distal (>10kb) Multiome | 68 | |
| chr10:113,678,876–113,680,785 | 174.5 kb | Distal (>10kb) Multiome | 869 | |
| chr10:113,853,906–113,855,611 | 221 bp | At TSS Multiome | 938 | |
| chr10:113,855,700–113,856,017 | 1.6 kb | Proximal (<10kb) | 127 | |
| chr10:114,042,897–114,045,651 | 189.4 kb | Distal (>10kb) Multiome | 503 |
Genomic view of the DCLRE1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.