This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for CASP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:113,385,020–113,385,635 | 293.9 kb | Distal (>10kb) Multiome | 304 | |
| chr10:113,410,316–113,411,770 | 268.3 kb | Distal (>10kb) Multiome | 236 | |
| chr10:113,471,640–113,472,197 | 207.3 kb | Distal (>10kb) Multiome | 13 | |
| chr10:113,555,598–113,556,217 | 123.2 kb | Distal (>10kb) Multiome | 129 | |
| chr10:113,563,298–113,563,961 | 115.5 kb | Distal (>10kb) Multiome | 379 | |
| chr10:113,572,599–113,573,340 | 106.2 kb | Distal (>10kb) Multiome | 68 | |
| chr10:113,678,876–113,680,785 | 646 bp | At TSS Multiome | 869 | |
| chr10:113,853,906–113,855,611 | 175.4 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the CASP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.