chr10 : 692,735 – 693,228

493 bp 89 TFs 4 linked genes

This 493 bp open chromatin element is linked to 4 target genes and is bound by 89 transcription factors.

Linked Genes

4 genes

Gene	Dist. to TSS	Distance	Link type
DIP2C	3.1 kb	Proximal	Proximity
LARP4B	238.7 kb	Distal	Multiome
ENSG00000205740	295.3 kb	Distal	Multiome
GTPBP4	295.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

89 transcription factors

AR 1 dataset

ChIP LNCaP_FOXA1 ERP003503.AR.LNCaP_FOXA1 203 bp overlap

ARID1A 1 dataset

ChIP RMG-I GSE104545.ARID1A.RMG-I 142 bp overlap

BARX1 1 dataset

Motif DE_48h DE_48h-BARX1_MA0875.2 6 bp overlap

BCL6 2 datasets

ChIP B-cell_GERMINAL_CENTER GSE43350.BCL6.B-cell_GERMINAL_CENTER 159 bp overlap

ChIP OCI-Ly1 GSE29282.BCL6.OCI-Ly1 165 bp overlap

BSX 1 dataset

Motif DE_48h DE_48h-BSX_MA0876.2 6 bp overlap

Bcl11B 1 dataset

Motif DE_48h DE_48h-Bcl11B_MA1989.2 9 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF274GAT 196 bp overlap

DLX1 1 dataset

Motif DE_48h DE_48h-DLX1_MA0879.3 6 bp overlap

DLX6 1 dataset

Motif DE_48h DE_48h-DLX6_MA0882.2 6 bp overlap

Dlx3 1 dataset

Motif DE_48h DE_48h-Dlx3_MA0880.2 6 bp overlap

Dlx4 1 dataset

Motif DE_48h DE_48h-Dlx4_MA0881.2 6 bp overlap

EHF 1 dataset

Motif DE_48h DE_48h-EHF_MA0598.4 9 bp overlap

ELF1 1 dataset

Motif DE_48h DE_48h-ELF1_MA0473.4 9 bp overlap

ELF3 1 dataset

ChIP PDAC_SHCTR GSE64557.ELF3.PDAC_SHCTR 164 bp overlap

ESR1 1 dataset

ChIP MCF-7_DHT GSE99626.ESR1.MCF-7_DHT 159 bp overlap

EZH2 1 dataset

ChIP THP-1 GSE135024.EZH2.THP-1 206 bp overlap

FIGLA 1 dataset

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

FOXA1 2 datasets

ChIP PDAC_SHCTR GSE64557.FOXA1.PDAC_SHCTR 262 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 237 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 392 bp overlap

ChIP DE DE-FOXA2-2 399 bp overlap

FOXO6 1 dataset

Motif DE_48h DE_48h-FOXO6_MA0849.1 7 bp overlap

GATA2 1 dataset

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 389 bp overlap

ChIP DE DE-GATA4-2 405 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 401 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 432 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 371 bp overlap

GATA6 12 datasets

ChIP AGS GSE51936.GATA6.AGS 80 bp overlap

ChIP DE DE-GATA6-1 392 bp overlap

ChIP DE DE-GATA6-2 442 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 300 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 412 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 335 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 386 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 372 bp overlap

ChIP foregut GSE117136.GATA6.foregut 350 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 292 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 301 bp overlap

GBX2 1 dataset

Motif DE_48h DE_48h-GBX2_MA0890.2 6 bp overlap

Gata3 1 dataset

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

HESX1 1 dataset

Motif DE_48h DE_48h-HESX1_MA0894.2 6 bp overlap

HNF4A 1 dataset

ChIP KATO-III GSE114018.HNF4A.KATO-III 169 bp overlap

HOXA7 1 dataset

Motif DE_48h DE_48h-HOXA7_MA1498.3 6 bp overlap

Hand1::Tcf3 1 dataset

Motif DE_48h DE_48h-Hand1Tcf3_MA0092.2 9 bp overlap

IKZF2 1 dataset

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

IRF1 1 dataset

ChIP PDAC GSE64557.IRF1.PDAC 199 bp overlap

KDM1A 3 datasets

ChIP pancreatic-progenitor_GT GSE104840.KDM1A.pancreatic-progenitor_GT 396 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 444 bp overlap

ChIP pancreatic-progenitor_PP2-KDM1A-inh GSE104840.KDM1A.pancreatic-progenitor_PP2-KDM1A-inh 345 bp overlap

KLF6 1 dataset

ChIP PDAC GSE64557.KLF6.PDAC 147 bp overlap

LBX2 1 dataset

Motif DE_48h DE_48h-LBX2_MA0699.2 6 bp overlap

LHX2 1 dataset

Motif DE_48h DE_48h-LHX2_MA0700.3 6 bp overlap

MEIS1 1 dataset

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

MSX1 1 dataset

Motif DE_48h DE_48h-MSX1_MA0666.3 6 bp overlap

MSX2 1 dataset

Motif DE_48h DE_48h-MSX2_MA0708.3 6 bp overlap

MYOD1 3 datasets

Motif DE_48h DE_48h-MYOD1_MA0499.3 9 bp overlap

ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 179 bp overlap

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 145 bp overlap

Msx3 1 dataset

Motif DE_48h DE_48h-Msx3_MA0709.2 6 bp overlap

Nobox 1 dataset

Motif DE_48h DE_48h-Nobox_MA0125.2 6 bp overlap

PAX5 5 datasets

ChIP GM12878 ENCFF482PUW 194 bp overlap

ChIP GM12878 ENCSR000BHJ.PAX5.GM12878 170 bp overlap

ChIP GM12878 ENCSR000BHD.PAX5.GM12878 156 bp overlap

ChIP GM12891 ENCSR000BJH.PAX5.GM12891 110 bp overlap

ChIP OCI-Ly7 GSE69558.PAX5.OCI-Ly7 213 bp overlap

PBX3 1 dataset

Motif DE_48h DE_48h-PBX3_MA1114.2 11 bp overlap

PDX1 1 dataset

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 333 bp overlap

PKNOX1 1 dataset

Motif DE_48h DE_48h-PKNOX1_MA0782.3 10 bp overlap

PRDM15 4 datasets

ChIP Hep-G2 ENCSR011INW.PRDM15.Hep-G2 250 bp overlap

ChIP HepG2 ENCFF259LUZ 427 bp overlap

ChIP WTC11 ENCFF108TMF 378 bp overlap

ChIP WTC11 ENCFF108TMF 298 bp overlap

Ptf1A 1 dataset

Motif DE_48h DE_48h-Ptf1A_MA1620.2 8 bp overlap

RAX 1 dataset

Motif DE_48h DE_48h-RAX_MA0718.2 6 bp overlap

RBBP4 1 dataset

ChIP SCMC GSE155861.RBBP4.SCMC 166 bp overlap

RUNX1 1 dataset

ChIP epididymis_HEE GSE109061.RUNX1.epididymis_HEE 402 bp overlap

SCRT1 3 datasets

ChIP HEK293 ENCFF513YVP 417 bp overlap

ChIP HEK293 ENCFF513YVP 266 bp overlap

ChIP HEK293 ENCSR605MGM.SCRT1.HEK293 489 bp overlap

SCRT2 1 dataset

ChIP HEK293 ENCFF711QQB 318 bp overlap

SFPQ 1 dataset

ChIP LTAD_EtOH GSE94577.SFPQ.LTAD_EtOH 173 bp overlap

SMAD2 3 datasets

Motif DE_48h DE_48h-SMAD2_MA1964.2 6 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 183 bp overlap

SMAD2-3 4 datasets

ChIP HGrC1_C134W-TGF GSE138496.SMAD2-3.HGrC1_C134W-TGF 169 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 368 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 375 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 493 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 360 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 375 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 362 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 491 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 445 bp overlap

SMAD4 2 datasets

ChIP Caco-2 GSE112946.SMAD4.Caco-2 175 bp overlap

ChIP endoderm GSE29422.SMAD4.endoderm 168 bp overlap

SMARCA4 3 datasets

ChIP Aska-SS GSE108025.SMARCA4.Aska-SS 244 bp overlap

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-K785R 204 bp overlap

ChIP HS-SY-2_HA-tagged GSE108926.SMARCA4.HS-SY-2_HA-tagged 493 bp overlap

SMARCC1 1 dataset

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCC1.BIN-67_lentivirus-SMARCA4-K785R 237 bp overlap

SNAI2 2 datasets

Motif DE_48h DE_48h-SNAI2_MA0745.3 8 bp overlap

ChIP keratinocyte_SNAI2 GSE55421.SNAI2.keratinocyte_SNAI2 246 bp overlap

SNAI3 1 dataset

Motif DE_48h DE_48h-SNAI3_MA1559.2 9 bp overlap

SOX13 1 dataset

Motif DE_48h DE_48h-SOX13_MA1120.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 280 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 433 bp overlap

SOX2 1 dataset

Motif DE_48h DE_48h-SOX2_MA0143.5 7 bp overlap

SS18 2 datasets

ChIP Aska-SS GSE108025.SS18.Aska-SS 245 bp overlap

ChIP SYO-1 GSE108025.SS18.SYO-1 394 bp overlap

STAT1_pS727 1 dataset

ChIP SET-2 GSE100566.STAT1_pS727.SET-2 319 bp overlap

Sox17 1 dataset

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Sox3 1 dataset

Motif DE_48h DE_48h-Sox3_MA0514.3 7 bp overlap

Sox6 1 dataset

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Sox7 1 dataset

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

TERF2 1 dataset

ChIP LCL GSE55053.TERF2.LCL 116 bp overlap

TRIM28 1 dataset

ChIP HEK293 ENCFF582MWI 397 bp overlap

TRPS1 1 dataset

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

ZBTB11 1 dataset

Motif DE_48h DE_48h-ZBTB11_MA2329.1 9 bp overlap

ZBTB24 1 dataset

ChIP HCT-116 GSE111683.ZBTB24.HCT-116 170 bp overlap

ZEB1 3 datasets

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

ChIP GM12878 ENCSR000BND.ZEB1.GM12878 145 bp overlap

ChIP PDAC GSE64557.ZEB1.PDAC 219 bp overlap

ZEB2 1 dataset

ChIP HEK293 ENCSR417VWF.ZEB2.HEK293 299 bp overlap

ZFP36 1 dataset

ChIP K-562 ENCSR776CYN.ZFP36.K-562 137 bp overlap

ZIC2 1 dataset

ChIP HEK293 ENCFF033NQQ 224 bp overlap

ZMYM3 2 datasets

ChIP Hep-G2 ENCSR848YWD.ZMYM3.Hep-G2 169 bp overlap

ChIP K-562_Ab_JH39-2-2F10 GSE97661.ZMYM3.K-562_Ab_JH39-2-2F10 204 bp overlap

ZNF257 1 dataset

Motif DE_48h DE_48h-ZNF257_MA1710.2 10 bp overlap

ZNF3 1 dataset

ChIP Hep-G2 ENCSR182QWU.ZNF3.Hep-G2 225 bp overlap

ZNF35 1 dataset

Motif DE_48h DE_48h-ZNF35_MA2333.1 7 bp overlap

ZNF436 1 dataset

ChIP HEK293 GSE76494.ZNF436.HEK293 211 bp overlap

ZNF534 1 dataset

ChIP HEK293T GSE78099.ZNF534.HEK293T 68 bp overlap

ZNF768 2 datasets

ChIP HEK293 ENCFF579QSI 337 bp overlap

ChIP HepG2 ENCFF388QCK 204 bp overlap

ZNF92 1 dataset

ChIP retina_pigment GSE60024.ZNF92.retina_pigment 276 bp overlap

ZSCAN5C 1 dataset

ChIP HEK293 ENCSR731AGO.ZSCAN5C.HEK293 201 bp overlap