This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for DIP2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIP2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIP2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:397,792–398,580 | 291.5 kb | Distal (>10kb) Multiome | 81 | |
| chr10:409,406–410,466 | 279.9 kb | Distal (>10kb) Multiome | 49 | |
| chr10:688,745–690,650 | 177 bp | At TSS Multiome | 470 | |
| chr10:692,735–693,228 | 3.4 kb | Proximal (<10kb) Multiome | 89 | |
| chr10:930,617–932,295 | 242.2 kb | Distal (>10kb) Multiome | 658 | |
| chr10:973,560–974,740 | 284.3 kb | Distal (>10kb) Multiome | 415 | |
| chr10:987,707–988,902 | 298.7 kb | Distal (>10kb) Multiome | 842 |
Genomic view of the DIP2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.