Transcription factors with Perturb-seq knockdown data for ENSG00000205740. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000205740 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000205740, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:688,745–690,650 | 298.5 kb | Distal (>10kb) Multiome | 470 | |
| chr10:692,735–693,228 | 295.3 kb | Distal (>10kb) Multiome | 89 | |
| chr10:930,617–932,295 | 56.5 kb | Distal (>10kb) Multiome | 658 | |
| chr10:973,560–974,740 | 14.3 kb | Distal (>10kb) Multiome | 415 | |
| chr10:987,707–988,902 | 25 bp | At TSS Multiome | 842 | |
| chr10:1,048,018–1,050,104 | 60.9 kb | Distal (>10kb) Multiome | 1021 | |
| chr10:1,056,026–1,057,235 | 68.4 kb | Distal (>10kb) Multiome | 863 |
Genomic view of the ENSG00000205740 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.