This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for LARP4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARP4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARP4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:688,745–690,650 | 241.9 kb | Distal (>10kb) Multiome | 470 | |
| chr10:692,735–693,228 | 238.7 kb | Distal (>10kb) Multiome | 89 | |
| chr10:930,617–932,295 | 161 bp | At TSS Multiome | 658 | |
| chr10:973,560–974,740 | 42.3 kb | Distal (>10kb) Multiome | 415 | |
| chr10:987,707–988,902 | 56.6 kb | Distal (>10kb) Multiome | 842 | |
| chr10:1,048,018–1,050,104 | 117.5 kb | Distal (>10kb) Multiome | 1021 | |
| chr10:1,056,026–1,057,235 | 125.0 kb | Distal (>10kb) Multiome | 863 |
Genomic view of the LARP4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.