chr8 : 121,756,389 – 121,757,302
913 bp 82 TFs 2 linked genes
This 913 bp open chromatin element is linked to HAS2 and HAS2-AS1 and is bound by 82 transcription factors.
Linked Genes
2 genes
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
HAS2 115.3 kb Distal Multiome
HAS2-AS1 116.9 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr8:121,751,389 – 121,762,302
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
82 transcription factors
Source
Cell type
Bcl11B 2 datasets
Motif DE_36h DE_36h-Bcl11B_MA1989.2 9 bp overlap
Motif DE_48h DE_48h-Bcl11B_MA1989.2 9 bp overlap
CTCF 1 dataset
Motif DE_36h DE_36h-CTCF_MA1929.2 31 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF798NMV 345 bp overlap
DPRX 2 datasets
Motif DE_36h DE_36h-DPRX_MA1480.2 9 bp overlap
Motif DE_48h DE_48h-DPRX_MA1480.2 9 bp overlap
DUXA 3 datasets
Motif DE_36h DE_36h-DUXA_MA0884.2 13 bp overlap
Motif DE_48h DE_48h-DUXA_MA0884.2 13 bp overlap
Motif DE_60h DE_60h-DUXA_MA0884.2 13 bp overlap
Dux 4 datasets
Motif DE_36h DE_36h-Dux_MA0611.3 11 bp overlap
Motif DE_36h DE_36h-Dux_MA0611.3 11 bp overlap
Motif DE_48h DE_48h-Dux_MA0611.3 11 bp overlap
Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 454 bp overlap
ETV1 3 datasets
Motif DE_36h DE_36h-ETV1_MA0761.3 9 bp overlap
Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap
Motif DE_60h DE_60h-ETV1_MA0761.3 9 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 710 bp overlap
ChIP DE DE-FOXA2-2 502 bp overlap
FOXO1::ELF1 3 datasets
Motif DE_36h DE_36h-FOXO1ELF1_MA1953.2 13 bp overlap
Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap
Motif DE_60h DE_60h-FOXO1ELF1_MA1953.2 13 bp overlap
FOXO1::ELK1 3 datasets
Motif DE_36h DE_36h-FOXO1ELK1_MA1954.2 13 bp overlap
Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap
Motif DE_60h DE_60h-FOXO1ELK1_MA1954.2 13 bp overlap
GATA1 3 datasets
Motif DE_36h DE_36h-GATA1_MA0035.5 7 bp overlap
Motif DE_48h DE_48h-GATA1_MA0035.5 7 bp overlap
Motif DE_60h DE_60h-GATA1_MA0035.5 7 bp overlap
GATA4 4 datasets
ChIP DE DE-GATA4-1 732 bp overlap
ChIP DE DE-GATA4-2 735 bp overlap
ChIP foregut GSE117136.GATA4.foregut 290 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 308 bp overlap
GATA6 12 datasets
ChIP DE DE-GATA6-1 732 bp overlap
ChIP DE DE-GATA6-2 685 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 693 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 739 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 665 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 739 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 861 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 749 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 688 bp overlap
ChIP foregut GSE117136.GATA6.foregut 418 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 310 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 278 bp overlap
HMGA1 1 dataset
ChIP IMR-90_RAS-induced GSE111841.HMGA1.IMR-90_RAS-induced 215 bp overlap
HOXB4 1 dataset
Motif DE_36h DE_36h-HOXB4_MA1499.2 6 bp overlap
HOXC4 1 dataset
Motif DE_36h DE_36h-HOXC4_MA1504.2 6 bp overlap
HOXD4 1 dataset
Motif DE_36h DE_36h-HOXD4_MA1507.2 6 bp overlap
HSF1 1 dataset
ChIP MO91 GSE45852.HSF1.MO91 176 bp overlap
IRF3 1 dataset
Motif DE_36h DE_36h-IRF3_MA1418.2 17 bp overlap
IRF4 1 dataset
ChIP OCI-Ly10 GSE142493.IRF4.OCI-Ly10 149 bp overlap
IRF7 1 dataset
Motif DE_36h DE_36h-IRF7_MA0772.2 13 bp overlap
Irf1 1 dataset
Motif DE_36h DE_36h-Irf1_MA0050.4 11 bp overlap
JUN 3 datasets
ChIP DE_D1 S08-DE-d1-JUN-exp1 372 bp overlap
ChIP DE_D2 S02-DE-d2-JUN-exp1 412 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 399 bp overlap
LIN54 1 dataset
Motif DE_36h DE_36h-LIN54_MA0619.2 7 bp overlap
Lhx1 3 datasets
Motif DE_36h DE_36h-Lhx1_MA1518.3 10 bp overlap
Motif DE_48h DE_48h-Lhx1_MA1518.3 10 bp overlap
Motif DE_60h DE_60h-Lhx1_MA1518.3 10 bp overlap
MEIS1 5 datasets
Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap
Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
MEIS2 3 datasets
Motif DE_36h DE_36h-MEIS2_MA0774.1 8 bp overlap
Motif DE_48h DE_48h-MEIS2_MA0774.1 8 bp overlap
Motif DE_60h DE_60h-MEIS2_MA0774.1 8 bp overlap
MGA::EVX1 2 datasets
Motif DE_36h DE_36h-MGAEVX1_MA1960.2 11 bp overlap
Motif DE_48h DE_48h-MGAEVX1_MA1960.2 11 bp overlap
MTA2 1 dataset
ChIP GM12878 ENCSR293QAR.MTA2.GM12878 234 bp overlap
NEUROD1 2 datasets
ChIP D283-Med GSE92582.NEUROD1.D283-Med 501 bp overlap
ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 275 bp overlap
NFYA 1 dataset
Motif DE_36h DE_36h-NFYA_MA0060.4 8 bp overlap
NFYC 1 dataset
Motif DE_36h DE_36h-NFYC_MA1644.2 7 bp overlap
NR3C1 1 dataset
ChIP MCF-7 GSE152203.NR3C1.MCF-7 188 bp overlap
PAX4 3 datasets
Motif DE_36h DE_36h-PAX4_MA0068.2 8 bp overlap
Motif DE_48h DE_48h-PAX4_MA0068.2 8 bp overlap
Motif DE_60h DE_60h-PAX4_MA0068.2 8 bp overlap
PBX3 3 datasets
Motif DE_36h DE_36h-PBX3_MA1114.2 11 bp overlap
Motif DE_48h DE_48h-PBX3_MA1114.2 11 bp overlap
Motif DE_60h DE_60h-PBX3_MA1114.2 11 bp overlap
PHOX2B 3 datasets
Motif DE_36h DE_36h-PHOX2B_MA0681.3 12 bp overlap
Motif DE_48h DE_48h-PHOX2B_MA0681.3 12 bp overlap
Motif DE_60h DE_60h-PHOX2B_MA0681.3 12 bp overlap
PKNOX1 3 datasets
Motif DE_36h DE_36h-PKNOX1_MA0782.3 10 bp overlap
Motif DE_48h DE_48h-PKNOX1_MA0782.3 10 bp overlap
Motif DE_60h DE_60h-PKNOX1_MA0782.3 10 bp overlap
Prdm15 1 dataset
Motif DE_36h DE_36h-Prdm15_MA1616.2 11 bp overlap
Prdm5 1 dataset
Motif DE_36h DE_36h-Prdm5_MA1999.2 11 bp overlap
REST 1 dataset
ChIP neural ENCSR000BTV.REST.neural 119 bp overlap
RORA 3 datasets
Motif DE_36h DE_36h-RORA_MA0072.2 11 bp overlap
Motif DE_48h DE_48h-RORA_MA0072.2 11 bp overlap
Motif DE_60h DE_60h-RORA_MA0072.2 11 bp overlap
RORB 3 datasets
Motif DE_36h DE_36h-RORB_MA1150.2 10 bp overlap
Motif DE_48h DE_48h-RORB_MA1150.2 10 bp overlap
Motif DE_60h DE_60h-RORB_MA1150.2 10 bp overlap
RORC 3 datasets
Motif DE_36h DE_36h-RORC_MA1151.2 10 bp overlap
Motif DE_48h DE_48h-RORC_MA1151.2 10 bp overlap
Motif DE_60h DE_60h-RORC_MA1151.2 10 bp overlap
RREB1 3 datasets
Motif DE_36h DE_36h-RREB1_MA0073.2 19 bp overlap
Motif DE_48h DE_48h-RREB1_MA0073.2 19 bp overlap
Motif DE_60h DE_60h-RREB1_MA0073.2 19 bp overlap
RUNX2 2 datasets
Motif DE_36h DE_36h-RUNX2_MA0511.2 9 bp overlap
Motif DE_48h DE_48h-RUNX2_MA0511.2 9 bp overlap
Runx1 2 datasets
Motif DE_36h DE_36h-Runx1_MA0002.3 9 bp overlap
Motif DE_48h DE_48h-Runx1_MA0002.3 9 bp overlap
SATB1 1 dataset
ChIP MCF-10A_N-term_CUT1 GSE123292.SATB1.MCF-10A_N-term_CUT1 130 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 599 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 368 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 366 bp overlap
SMAD2_3 4 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 293 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 272 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 566 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 653 bp overlap
SMAD3 1 dataset
ChIP endoderm GSE29422.SMAD3.endoderm 156 bp overlap
SMARCA4 1 dataset
ChIP hiPSC GSE124903.SMARCA4.hiPSC 261 bp overlap
SMARCC1 1 dataset
ChIP hiPSC GSE124903.SMARCC1.hiPSC 234 bp overlap
SOX15 1 dataset
Motif DE_36h DE_36h-SOX15_MA1152.2 7 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 481 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 495 bp overlap
SOX18 1 dataset
Motif DE_36h DE_36h-SOX18_MA1563.2 8 bp overlap
SOX8 1 dataset
Motif DE_36h DE_36h-SOX8_MA0868.3 7 bp overlap
SOX9 1 dataset
Motif DE_36h DE_36h-SOX9_MA0077.2 8 bp overlap
SPDEF 3 datasets
Motif DE_36h DE_36h-SPDEF_MA0686.2 10 bp overlap
Motif DE_48h DE_48h-SPDEF_MA0686.2 10 bp overlap
Motif DE_60h DE_60h-SPDEF_MA0686.2 10 bp overlap
SPIB 5 datasets
Motif DE_36h DE_36h-SPIB_MA0081.3 13 bp overlap
Motif DE_36h DE_36h-SPIB_MA0081.3 13 bp overlap
Motif DE_48h DE_48h-SPIB_MA0081.3 13 bp overlap
Motif DE_48h DE_48h-SPIB_MA0081.3 13 bp overlap
Motif DE_60h DE_60h-SPIB_MA0081.3 13 bp overlap
SREBF1 4 datasets
Motif DE_36h DE_36h-SREBF1_MA0595.1 10 bp overlap
Motif DE_36h DE_36h-SREBF1_MA0829.3 10 bp overlap
Motif DE_48h DE_48h-SREBF1_MA0595.1 10 bp overlap
Motif DE_48h DE_48h-SREBF1_MA0829.3 10 bp overlap
SREBF2 2 datasets
Motif DE_36h DE_36h-SREBF2_MA0596.1 10 bp overlap
Motif DE_48h DE_48h-SREBF2_MA0596.1 10 bp overlap
SRY 1 dataset
Motif DE_36h DE_36h-SRY_MA0084.2 7 bp overlap
STAT1::STAT2 3 datasets
Motif DE_36h DE_36h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_60h DE_60h-STAT1STAT2_MA0517.2 13 bp overlap
Sox17 1 dataset
Motif DE_36h DE_36h-Sox17_MA0078.3 10 bp overlap
Sox5 1 dataset
Motif DE_36h DE_36h-Sox5_MA0087.3 8 bp overlap
Sox6 1 dataset
Motif DE_36h DE_36h-Sox6_MA0515.1 10 bp overlap
Sox7 1 dataset
Motif DE_36h DE_36h-Sox7_MA2095.1 10 bp overlap
Spi1 3 datasets
Motif DE_36h DE_36h-Spi1_MA0080.7 13 bp overlap
Motif DE_48h DE_48h-Spi1_MA0080.7 13 bp overlap
Motif DE_60h DE_60h-Spi1_MA0080.7 13 bp overlap
Stat2 4 datasets
Motif DE_36h DE_36h-Stat2_MA1623.2 10 bp overlap
Motif DE_36h DE_36h-Stat2_MA1623.2 10 bp overlap
Motif DE_48h DE_48h-Stat2_MA1623.2 10 bp overlap
Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap
T 2 datasets
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 376 bp overlap
ChIP H9_MESODERM GSE60606.T.H9_MESODERM 262 bp overlap
TBX2 1 dataset
ChIP Kelly GSE94822.TBX2.Kelly 155 bp overlap
TBX21 1 dataset
ChIP Th1_CD3-CD28_donor2 GSE81881.TBX21.Th1_CD3-CD28_donor2 158 bp overlap
ZBTB6 1 dataset
Motif DE_36h DE_36h-ZBTB6_MA1581.2 9 bp overlap
ZIM3 2 datasets
Motif DE_36h DE_36h-ZIM3_MA1709.2 11 bp overlap
Motif DE_48h DE_48h-ZIM3_MA1709.2 11 bp overlap
ZNF547 1 dataset
Motif DE_36h DE_36h-ZNF547_MA2334.1 13 bp overlap
ZNF558 1 dataset
Motif DE_36h DE_36h-ZNF558_MA2335.1 29 bp overlap
ZNF582 2 datasets
Motif DE_36h DE_36h-ZNF582_MA1983.2 19 bp overlap
Motif DE_48h DE_48h-ZNF582_MA1983.2 19 bp overlap
ZNF652 1 dataset
Motif DE_36h DE_36h-ZNF652_MA1657.2 9 bp overlap
ZNF75A 6 datasets
Motif DE_36h DE_36h-ZNF75A_MA2097.1 12 bp overlap
Motif DE_36h DE_36h-ZNF75A_MA2097.1 12 bp overlap
Motif DE_48h DE_48h-ZNF75A_MA2097.1 12 bp overlap
Motif DE_48h DE_48h-ZNF75A_MA2097.1 12 bp overlap
Motif DE_60h DE_60h-ZNF75A_MA2097.1 12 bp overlap
Motif DE_60h DE_60h-ZNF75A_MA2097.1 12 bp overlap
ZNF766 1 dataset
Motif DE_36h DE_36h-ZNF766_MA2098.1 9 bp overlap
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