chr8 : 32,394,061 – 32,395,020
959 bp 94 TFs 1 linked gene
This 959 bp open chromatin element is linked to NRG1 and is bound by 94 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
NRG1 755.0 kb Distal Multiome+HiCAR
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr8:32,389,061 – 32,400,020
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
94 transcription factors
Source
Cell type
AR 2 datasets
ChIP LNCaP GSE80256.AR.LNCaP 255 bp overlap
ChIP MDA-MB-453_R1881_SIPIAS1 GSE70161.AR.MDA-MB-453_R1881_SIPIAS1 100 bp overlap
ARNT::HIF1A 3 datasets
Motif DE_48h DE_48h-ARNTHIF1A_MA0259.2 5 bp overlap
Motif DE_60h DE_60h-ARNTHIF1A_MA0259.2 5 bp overlap
Motif DE_72h DE_72h-ARNTHIF1A_MA0259.2 5 bp overlap
Arid3a 1 dataset
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
CEBPA 1 dataset
Motif DE_60h DE_60h-CEBPA_MA0102.5 10 bp overlap
CEBPD 1 dataset
Motif DE_60h DE_60h-CEBPD_MA0836.3 8 bp overlap
CTCF 1 dataset
ChIP HAP1_clone21_CTCF-CRISPR GSE152721.CTCF.HAP1_clone21_CTCF-CRISPR 233 bp overlap
CUX1 1 dataset
Motif DE_60h DE_60h-CUX1_MA0754.3 9 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF896HSY 251 bp overlap
Crx 1 dataset
Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap
DMRT3 3 datasets
Motif DE_48h DE_48h-DMRT3_MA0610.2 7 bp overlap
Motif DE_60h DE_60h-DMRT3_MA0610.2 7 bp overlap
Motif DE_72h DE_72h-DMRT3_MA0610.2 7 bp overlap
DMRTC2 3 datasets
Motif DE_48h DE_48h-DMRTC2_MA1479.2 11 bp overlap
Motif DE_60h DE_60h-DMRTC2_MA1479.2 11 bp overlap
Motif DE_72h DE_72h-DMRTC2_MA1479.2 11 bp overlap
Dmrt1 3 datasets
Motif DE_48h DE_48h-Dmrt1_MA1603.2 9 bp overlap
Motif DE_60h DE_60h-Dmrt1_MA1603.2 9 bp overlap
Motif DE_72h DE_72h-Dmrt1_MA1603.2 9 bp overlap
Dux 1 dataset
Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap
EBF1 2 datasets
ChIP ASC GSE54889.EBF1.ASC 131 bp overlap
ChIP MUTUL GSE75503.EBF1.MUTUL 357 bp overlap
EBF3 1 dataset
Motif DE_60h DE_60h-EBF3_MA1637.2 9 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 417 bp overlap
ERF::FOXI1 1 dataset
Motif DE_48h DE_48h-ERFFOXI1_MA1935.2 10 bp overlap
ERF::FOXO1 1 dataset
Motif DE_48h DE_48h-ERFFOXO1_MA1936.2 12 bp overlap
ETV2::DRGX 1 dataset
Motif DE_48h DE_48h-ETV2DRGX_MA1940.2 12 bp overlap
ETV2::FOXI1 1 dataset
Motif DE_48h DE_48h-ETV2FOXI1_MA1942.2 11 bp overlap
ETV5::DRGX 1 dataset
Motif DE_48h DE_48h-ETV5DRGX_MA1944.2 12 bp overlap
Ebf2 1 dataset
Motif DE_60h DE_60h-Ebf2_MA1604.2 9 bp overlap
FLI1::DRGX 1 dataset
Motif DE_48h DE_48h-FLI1DRGX_MA1949.2 14 bp overlap
FLI1::FOXI1 1 dataset
Motif DE_48h DE_48h-FLI1FOXI1_MA1950.2 11 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 782 bp overlap
ChIP DE DE-FOXA2-2 875 bp overlap
FOXO1::ELF1 1 dataset
Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap
FOXO1::ELK1 1 dataset
Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap
FOXO1::FLI1 1 dataset
Motif DE_48h DE_48h-FOXO1FLI1_MA1956.2 13 bp overlap
GATA1 1 dataset
ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 153 bp overlap
GATA4 9 datasets
ChIP DE DE-GATA4-1 932 bp overlap
ChIP DE DE-GATA4-2 940 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap
Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap
ChIP foregut GSE117136.GATA4.foregut 288 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 622 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 329 bp overlap
GATA6 8 datasets
ChIP DE DE-GATA6-1 680 bp overlap
ChIP DE DE-GATA6-2 803 bp overlap
Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap
Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap
Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 504 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 555 bp overlap
ChIP foregut GSE117136.GATA6.foregut 353 bp overlap
GSC 1 dataset
Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap
GSC2 1 dataset
Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap
Gata3 3 datasets
Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap
Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap
Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap
HNF4A 2 datasets
Motif DE_48h DE_48h-HNF4A_MA1494.2 14 bp overlap
Motif DE_60h DE_60h-HNF4A_MA1494.2 14 bp overlap
Hmx2 1 dataset
Motif DE_48h DE_48h-Hmx2_MA0897.2 15 bp overlap
Hmx3 3 datasets
Motif DE_48h DE_48h-Hmx3_MA0898.2 9 bp overlap
Motif DE_60h DE_60h-Hmx3_MA0898.2 9 bp overlap
Motif DE_72h DE_72h-Hmx3_MA0898.2 9 bp overlap
IKZF1 2 datasets
Motif DE_48h DE_48h-IKZF1_MA1508.2 8 bp overlap
Motif DE_60h DE_60h-IKZF1_MA1508.2 8 bp overlap
ISL2 3 datasets
Motif DE_48h DE_48h-ISL2_MA0914.2 6 bp overlap
Motif DE_60h DE_60h-ISL2_MA0914.2 6 bp overlap
Motif DE_72h DE_72h-ISL2_MA0914.2 6 bp overlap
JUN 1 dataset
ChIP DE_D2 S02-DE-d2-JUN-exp1 423 bp overlap
MAFK 1 dataset
ChIP HepG2 ENCFF743ZOF 158 bp overlap
MEF2C 1 dataset
Motif DE_60h DE_60h-MEF2C_MA0497.2 11 bp overlap
MEIS1 6 datasets
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap
NR2F1 3 datasets
Motif DE_48h DE_48h-NR2F1_MA1538.1 15 bp overlap
Motif DE_60h DE_60h-NR2F1_MA1538.1 15 bp overlap
Motif DE_72h DE_72h-NR2F1_MA1538.1 15 bp overlap
NR4A1 4 datasets
Motif DE_48h DE_48h-NR4A1_MA1112.3 8 bp overlap
Motif DE_60h DE_60h-NR4A1_MA1112.3 8 bp overlap
Motif DE_60h DE_60h-NR4A1_MA1112.3 8 bp overlap
Motif DE_72h DE_72h-NR4A1_MA1112.3 8 bp overlap
NR4A2 1 dataset
Motif DE_60h DE_60h-NR4A2_MA0160.3 8 bp overlap
Nkx3-2 3 datasets
Motif DE_48h DE_48h-Nkx3-2_MA0122.4 10 bp overlap
Motif DE_60h DE_60h-Nkx3-2_MA0122.4 10 bp overlap
Motif DE_72h DE_72h-Nkx3-2_MA0122.4 10 bp overlap
Nr2F6 2 datasets
Motif DE_48h DE_48h-Nr2F6_MA0728.1 15 bp overlap
Motif DE_60h DE_60h-Nr2F6_MA0728.1 15 bp overlap
OTX1 1 dataset
Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap
PBX3 3 datasets
Motif DE_48h DE_48h-PBX3_MA1114.2 11 bp overlap
Motif DE_60h DE_60h-PBX3_MA1114.2 11 bp overlap
Motif DE_72h DE_72h-PBX3_MA1114.2 11 bp overlap
PITX1 1 dataset
Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap
PITX2 1 dataset
Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap
PITX3 1 dataset
Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap
PKNOX1 3 datasets
Motif DE_48h DE_48h-PKNOX1_MA0782.3 10 bp overlap
Motif DE_60h DE_60h-PKNOX1_MA0782.3 10 bp overlap
Motif DE_72h DE_72h-PKNOX1_MA0782.3 10 bp overlap
POLR2A 1 dataset
ChIP neural cell ENCFF604SPB 270 bp overlap
POU4F2 1 dataset
Motif DE_48h DE_48h-POU4F2_MA0683.2 15 bp overlap
PPARA::RXRA 2 datasets
Motif DE_48h DE_48h-PPARARXRA_MA1148.2 17 bp overlap
Motif DE_60h DE_60h-PPARARXRA_MA1148.2 17 bp overlap
PRDM9 1 dataset
Motif DE_48h DE_48h-PRDM9_MA1723.2 20 bp overlap
Pgr 1 dataset
Motif DE_60h DE_60h-Pgr_MA2323.1 17 bp overlap
Prdm15 3 datasets
Motif DE_48h DE_48h-Prdm15_MA1616.2 11 bp overlap
Motif DE_60h DE_60h-Prdm15_MA1616.2 11 bp overlap
Motif DE_72h DE_72h-Prdm15_MA1616.2 11 bp overlap
Prdm4 1 dataset
Motif DE_60h DE_60h-Prdm4_MA1647.3 11 bp overlap
Prdm5 1 dataset
Motif DE_48h DE_48h-Prdm5_MA1999.2 11 bp overlap
RAD21 2 datasets
ChIP HAP1 GSE152721.RAD21.HAP1 187 bp overlap
ChIP HAP1_CTCF GSE126634.RAD21.HAP1_CTCF 576 bp overlap
RARA 2 datasets
Motif DE_48h DE_48h-RARA_MA0729.1 18 bp overlap
Motif DE_60h DE_60h-RARA_MA0729.1 18 bp overlap
RBPJ 2 datasets
Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap
Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap
RELA 1 dataset
ChIP SGBS_TNF GSE64233.RELA.SGBS_TNF 239 bp overlap
RHOXF1 1 dataset
Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap
Rarb 2 datasets
Motif DE_48h DE_48h-Rarb_MA0857.1 16 bp overlap
Motif DE_60h DE_60h-Rarb_MA0857.1 16 bp overlap
Rarg 2 datasets
Motif DE_48h DE_48h-Rarg_MA0859.2 15 bp overlap
Motif DE_60h DE_60h-Rarg_MA0859.2 15 bp overlap
Rfx6 1 dataset
Motif DE_60h DE_60h-Rfx6_MA1724.2 9 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 168 bp overlap
SMAD2-3 1 dataset
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 670 bp overlap
SMAD2_3 2 datasets
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 568 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 544 bp overlap
SMAD3 1 dataset
ChIP endoderm GSE29422.SMAD3.endoderm 156 bp overlap
SMAD4 1 dataset
ChIP endoderm GSE29422.SMAD4.endoderm 240 bp overlap
SOX10 3 datasets
Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap
Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap
Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 313 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 439 bp overlap
SP5 1 dataset
Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap
TBX18 2 datasets
Motif DE_48h DE_48h-TBX18_MA1565.2 9 bp overlap
Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap
TGIF1 2 datasets
Motif DE_48h DE_48h-TGIF1_MA0796.1 12 bp overlap
Motif DE_60h DE_60h-TGIF1_MA0796.1 12 bp overlap
TRPS1 3 datasets
Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap
Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap
Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap
ZFP42 1 dataset
Motif DE_60h DE_60h-ZFP42_MA1651.2 13 bp overlap
ZKSCAN5 2 datasets
Motif DE_48h DE_48h-ZKSCAN5_MA1652.2 9 bp overlap
Motif DE_60h DE_60h-ZKSCAN5_MA1652.2 9 bp overlap
ZNF135 1 dataset
Motif DE_48h DE_48h-ZNF135_MA1587.1 14 bp overlap
ZNF35 1 dataset
Motif DE_48h DE_48h-ZNF35_MA2333.1 7 bp overlap
ZNF354A 2 datasets
Motif DE_48h DE_48h-ZNF354A_MA1978.2 20 bp overlap
Motif DE_60h DE_60h-ZNF354A_MA1978.2 20 bp overlap
ZNF418 1 dataset
Motif DE_60h DE_60h-ZNF418_MA1980.1 15 bp overlap
ZNF558 2 datasets
Motif DE_48h DE_48h-ZNF558_MA2335.1 29 bp overlap
Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap
ZNF701 2 datasets
Motif DE_48h DE_48h-ZNF701_MA1987.2 17 bp overlap
Motif DE_60h DE_60h-ZNF701_MA1987.2 17 bp overlap
ZNF85 1 dataset
Motif DE_60h DE_60h-ZNF85_MA1720.2 12 bp overlap
ZSCAN29 2 datasets
Motif DE_48h DE_48h-ZSCAN29_MA1602.2 11 bp overlap
Motif DE_60h DE_60h-ZSCAN29_MA1602.2 11 bp overlap
ZSCAN4 2 datasets
Motif DE_48h DE_48h-ZSCAN4_MA1155.1 15 bp overlap
Motif DE_60h DE_60h-ZSCAN4_MA1155.1 15 bp overlap
Zfp809 2 datasets
Motif DE_48h DE_48h-Zfp809_MA2125.1 9 bp overlap
Motif DE_60h DE_60h-Zfp809_MA2125.1 9 bp overlap
Huangfu Lab · Publications · Resources · Contact