chr5 : 38,602,629 – 38,603,182

553 bp 77 TFs 3 linked genes

This 553 bp open chromatin element is linked to LIFR-AS1, LIFR, and OSMR and is bound by 77 transcription factors.

Linked Genes

3 genes

Gene	Dist. to TSS	Distance	Link type
LIFR-AS1	46.1 kb	Distal	Multiome
LIFR	46.2 kb	Distal	Multiome
OSMR	243.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

77 transcription factors

Ascl2 1 dataset

Motif DE_24h DE_24h-Ascl2_MA0816.1 10 bp overlap

BARX1 2 datasets

Motif DE_12h DE_12h-BARX1_MA0875.2 6 bp overlap

Motif DE_24h DE_24h-BARX1_MA0875.2 6 bp overlap

BHLHE22 1 dataset

Motif DE_24h DE_24h-BHLHE22_MA1635.2 6 bp overlap

BRD4 1 dataset

ChIP K-562_iBET-BD1-IFNG GSE138084.BRD4.K-562_iBET-BD1-IFNG 178 bp overlap

BSX 2 datasets

Motif DE_12h DE_12h-BSX_MA0876.2 6 bp overlap

Motif DE_24h DE_24h-BSX_MA0876.2 6 bp overlap

Bhlha15 1 dataset

Motif DE_24h DE_24h-Bhlha15_MA1472.3 8 bp overlap

DLX1 2 datasets

Motif DE_12h DE_12h-DLX1_MA0879.3 6 bp overlap

Motif DE_24h DE_24h-DLX1_MA0879.3 6 bp overlap

DLX6 2 datasets

Motif DE_12h DE_12h-DLX6_MA0882.2 6 bp overlap

Motif DE_24h DE_24h-DLX6_MA0882.2 6 bp overlap

Dlx3 2 datasets

Motif DE_12h DE_12h-Dlx3_MA0880.2 6 bp overlap

Motif DE_24h DE_24h-Dlx3_MA0880.2 6 bp overlap

Dlx4 2 datasets

Motif DE_12h DE_12h-Dlx4_MA0881.2 6 bp overlap

Motif DE_24h DE_24h-Dlx4_MA0881.2 6 bp overlap

EHF 1 dataset

Motif DE_24h DE_24h-EHF_MA0598.4 9 bp overlap

ELF1 1 dataset

Motif DE_24h DE_24h-ELF1_MA0473.4 9 bp overlap

ELF3 1 dataset

Motif DE_24h DE_24h-ELF3_MA0640.3 9 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 294 bp overlap

ETV1 1 dataset

Motif DE_12h DE_12h-ETV1_MA0761.3 9 bp overlap

ETV5::FOXO1 1 dataset

Motif DE_24h DE_24h-ETV5FOXO1_MA1947.2 10 bp overlap

Erg 1 dataset

Motif DE_24h DE_24h-Erg_MA0474.4 10 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 291 bp overlap

ChIP DE DE-FOXA2-2 336 bp overlap

GABPA 1 dataset

Motif DE_24h DE_24h-GABPA_MA0062.4 10 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 377 bp overlap

ChIP DE DE-GATA4-2 485 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 302 bp overlap

ChIP DE DE-GATA6-2 468 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 414 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 353 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 464 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 425 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 396 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 437 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 338 bp overlap

GBX2 2 datasets

Motif DE_12h DE_12h-GBX2_MA0890.2 6 bp overlap

Motif DE_24h DE_24h-GBX2_MA0890.2 6 bp overlap

HAND2 2 datasets

Motif DE_12h DE_12h-HAND2_MA1638.2 6 bp overlap

Motif DE_24h DE_24h-HAND2_MA1638.2 6 bp overlap

HESX1 2 datasets

Motif DE_12h DE_12h-HESX1_MA0894.2 6 bp overlap

Motif DE_24h DE_24h-HESX1_MA0894.2 6 bp overlap

HOXA7 2 datasets

Motif DE_12h DE_12h-HOXA7_MA1498.3 6 bp overlap

Motif DE_24h DE_24h-HOXA7_MA1498.3 6 bp overlap

IKZF2 1 dataset

Motif DE_24h DE_24h-IKZF2_MA2326.1 6 bp overlap

Ikzf3 1 dataset

Motif DE_24h DE_24h-Ikzf3_MA1992.2 9 bp overlap

JUN 4 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 449 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 453 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 412 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 453 bp overlap

LBX2 2 datasets

Motif DE_12h DE_12h-LBX2_MA0699.2 6 bp overlap

Motif DE_24h DE_24h-LBX2_MA0699.2 6 bp overlap

LHX2 2 datasets

Motif DE_12h DE_12h-LHX2_MA0700.3 6 bp overlap

Motif DE_24h DE_24h-LHX2_MA0700.3 6 bp overlap

MAX 2 datasets

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 332 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 329 bp overlap

MED26 1 dataset

ChIP U2OS_SHCTR GSE73742.MED26.U2OS_SHCTR 262 bp overlap

MEIS1 2 datasets

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

Motif DE_24h DE_24h-MEIS1_MA0498.3 5 bp overlap

MGA::EVX1 2 datasets

Motif DE_12h DE_12h-MGAEVX1_MA1960.2 11 bp overlap

Motif DE_24h DE_24h-MGAEVX1_MA1960.2 11 bp overlap

MSC 1 dataset

Motif DE_24h DE_24h-MSC_MA0665.1 10 bp overlap

MSX1 2 datasets

Motif DE_12h DE_12h-MSX1_MA0666.3 6 bp overlap

Motif DE_24h DE_24h-MSX1_MA0666.3 6 bp overlap

MSX2 2 datasets

Motif DE_12h DE_12h-MSX2_MA0708.3 6 bp overlap

Motif DE_24h DE_24h-MSX2_MA0708.3 6 bp overlap

MYF5 1 dataset

Motif DE_24h DE_24h-MYF5_MA1641.2 8 bp overlap

MYF6 1 dataset

Motif DE_24h DE_24h-MYF6_MA0667.1 10 bp overlap

MYOD1 2 datasets

Motif DE_24h DE_24h-MYOD1_MA0499.3 9 bp overlap

ChIP RD GSE137168.MYOD1.RD 189 bp overlap

MYOG 1 dataset

Motif DE_24h DE_24h-MYOG_MA0500.3 8 bp overlap

Msx3 2 datasets

Motif DE_12h DE_12h-Msx3_MA0709.2 6 bp overlap

Motif DE_24h DE_24h-Msx3_MA0709.2 6 bp overlap

NANOG 4 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 260 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 284 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 309 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 248 bp overlap

NHLH1 1 dataset

Motif DE_24h DE_24h-NHLH1_MA0048.3 9 bp overlap

Neurod2 1 dataset

Motif DE_24h DE_24h-Neurod2_MA1993.2 6 bp overlap

Nobox 2 datasets

Motif DE_12h DE_12h-Nobox_MA0125.2 6 bp overlap

Motif DE_24h DE_24h-Nobox_MA0125.2 6 bp overlap

Olig2 1 dataset

Motif DE_24h DE_24h-Olig2_MA1997.2 6 bp overlap

Ptf1A 3 datasets

Motif DE_24h DE_24h-Ptf1A_MA1618.2 9 bp overlap

Motif DE_24h DE_24h-Ptf1A_MA1619.2 8 bp overlap

Motif DE_24h DE_24h-Ptf1A_MA1620.2 8 bp overlap

RAX 2 datasets

Motif DE_12h DE_12h-RAX_MA0718.2 6 bp overlap

Motif DE_24h DE_24h-RAX_MA0718.2 6 bp overlap

Rhox11 1 dataset

Motif DE_24h DE_24h-Rhox11_MA0629.2 9 bp overlap

SMAD2 1 dataset

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 316 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 407 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 537 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 540 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 533 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 518 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 553 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 439 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 495 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 137 bp overlap

SMARCA4 1 dataset

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 169 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 395 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 468 bp overlap

SREBF1 2 datasets

Motif DE_12h DE_12h-SREBF1_MA0829.3 10 bp overlap

Motif DE_24h DE_24h-SREBF1_MA0829.3 10 bp overlap

Spz1 1 dataset

Motif DE_24h DE_24h-Spz1_MA0111.1 11 bp overlap

T 2 datasets

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 362 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 281 bp overlap

TAL1::TCF3 1 dataset

Motif DE_24h DE_24h-TAL1TCF3_MA0091.2 10 bp overlap

TBP 2 datasets

ChIP WA01 ENCSR000ECB.TBP.WA01 172 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 135 bp overlap

TEAD1 2 datasets

Motif DE_12h DE_12h-TEAD1_MA0090.4 9 bp overlap

Motif DE_24h DE_24h-TEAD1_MA0090.4 9 bp overlap

TEAD2 2 datasets

Motif DE_12h DE_12h-TEAD2_MA1121.2 7 bp overlap

Motif DE_24h DE_24h-TEAD2_MA1121.2 7 bp overlap

TEAD3 2 datasets

Motif DE_12h DE_12h-TEAD3_MA0808.1 8 bp overlap

Motif DE_24h DE_24h-TEAD3_MA0808.1 8 bp overlap

TEAD4 2 datasets

Motif DE_12h DE_12h-TEAD4_MA0809.3 8 bp overlap

Motif DE_24h DE_24h-TEAD4_MA0809.3 8 bp overlap

TFAP4 1 dataset

Motif DE_24h DE_24h-TFAP4_MA0691.1 10 bp overlap

TFAP4::FLI1 1 dataset

Motif DE_24h DE_24h-TFAP4FLI1_MA1967.2 14 bp overlap

Tcf12 1 dataset

Motif DE_24h DE_24h-Tcf12_MA0521.3 6 bp overlap

Tcf21 1 dataset

Motif DE_24h DE_24h-Tcf21_MA0832.2 10 bp overlap

Twist2 1 dataset

Motif DE_24h DE_24h-Twist2_MA0633.3 6 bp overlap

YY1 3 datasets

ChIP HCT-116 ENCSR000BNX.YY1.HCT-116 116 bp overlap

ChIP Hep-G2_RBM25-KD GSE120104.YY1.Hep-G2_RBM25-KD 395 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 284 bp overlap

ZNF189 1 dataset

Motif DE_24h DE_24h-ZNF189_MA1725.2 9 bp overlap

ZNF354C 1 dataset

Motif DE_24h DE_24h-ZNF354C_MA0130.1 6 bp overlap

Zic1::Zic2 1 dataset

Motif DE_24h DE_24h-Zic1Zic2_MA1628.2 7 bp overlap

Zic2 1 dataset

Motif DE_24h DE_24h-Zic2_MA1629.2 9 bp overlap

Zic3 1 dataset

Motif DE_24h DE_24h-Zic3_MA0697.3 7 bp overlap