This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for OSMR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSMR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSMR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:38,555,925–38,557,581 | 289.1 kb | Distal (>10kb) Multiome | 755 | |
| chr5:38,596,850–38,597,809 | 248.6 kb | Distal (>10kb) Multiome | 175 | |
| chr5:38,598,289–38,600,592 | 247.0 kb | Distal (>10kb) Multiome | 274 | |
| chr5:38,602,629–38,603,182 | 243.0 kb | Distal (>10kb) Multiome | 77 | |
| chr5:38,809,383–38,810,097 | 36.0 kb | Distal (>10kb) Multiome | 352 | |
| chr5:38,844,903–38,847,060 | 136 bp | At TSS Multiome | 868 | |
| chr5:39,072,981–39,075,472 | 228.6 kb | Distal (>10kb) Multiome | 1130 |
Genomic view of the OSMR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.