chr2 : 217,149,147 – 217,149,754

607 bp 75 TFs 1 linked gene

This 607 bp open chromatin element is linked to DIRC3 and is bound by 75 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
DIRC3		284.7 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

75 transcription factors

ATF2 1 dataset

Motif DE_48h DE_48h-ATF2_MA1632.2 10 bp overlap

BHLHE22 1 dataset

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

BRD3 3 datasets

ChIP K-562_DMSO GSE138084.BRD3.K-562_DMSO 195 bp overlap

ChIP K-562_DMSO-IFNG GSE138084.BRD3.K-562_DMSO-IFNG 257 bp overlap

ChIP MV4-11_DMSO GSE120715.BRD3.MV4-11_DMSO 141 bp overlap

BRD4 1 dataset

ChIP K-562_DMSO GSE138084.BRD4.K-562_DMSO 220 bp overlap

CDK6 1 dataset

ChIP KB_IL GSE52469.CDK6.KB_IL 100 bp overlap

CREB1 1 dataset

Motif DE_48h DE_48h-CREB1_MA0018.5 8 bp overlap

CREM 1 dataset

Motif DE_48h DE_48h-CREM_MA0609.3 10 bp overlap

EHF 2 datasets

Motif DE_36h DE_36h-EHF_MA0598.4 9 bp overlap

Motif DE_48h DE_48h-EHF_MA0598.4 9 bp overlap

ELF1 2 datasets

Motif DE_36h DE_36h-ELF1_MA0473.4 9 bp overlap

Motif DE_48h DE_48h-ELF1_MA0473.4 9 bp overlap

ELF3 2 datasets

Motif DE_36h DE_36h-ELF3_MA0640.3 9 bp overlap

Motif DE_48h DE_48h-ELF3_MA0640.3 9 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 254 bp overlap

ESR1 2 datasets

ChIP Ishikawa_siETV4-72h GSE129803.ESR1.Ishikawa_siETV4-72h 234 bp overlap

ChIP breast_tumor_Male_10 GSE104399.ESR1.breast_tumor_Male_10 162 bp overlap

ETV5::DRGX 2 datasets

Motif DE_36h DE_36h-ETV5DRGX_MA1944.2 12 bp overlap

Motif DE_48h DE_48h-ETV5DRGX_MA1944.2 12 bp overlap

ETV6 2 datasets

Motif DE_36h DE_36h-ETV6_MA0645.2 9 bp overlap

Motif DE_48h DE_48h-ETV6_MA0645.2 9 bp overlap

ETV7 2 datasets

Motif DE_36h DE_36h-ETV7_MA1708.2 9 bp overlap

Motif DE_48h DE_48h-ETV7_MA1708.2 9 bp overlap

EZH2 1 dataset

ChIP SU-DHL-5 GSE45982.EZH2.SU-DHL-5 70 bp overlap

Elf5 2 datasets

Motif DE_36h DE_36h-Elf5_MA0136.4 8 bp overlap

Motif DE_48h DE_48h-Elf5_MA0136.4 8 bp overlap

Erg 2 datasets

Motif DE_36h DE_36h-Erg_MA0474.4 10 bp overlap

Motif DE_48h DE_48h-Erg_MA0474.4 10 bp overlap

FOS::JUN 1 dataset

Motif DE_48h DE_48h-FOSJUN_MA1126.2 10 bp overlap

FOSL2::JUN 1 dataset

Motif DE_48h DE_48h-FOSL2JUN_MA1131.2 10 bp overlap

FOSL2::JUND 1 dataset

Motif DE_48h DE_48h-FOSL2JUND_MA1145.2 10 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 400 bp overlap

ChIP DE DE-FOXA2-2 329 bp overlap

GABPA 2 datasets

Motif DE_36h DE_36h-GABPA_MA0062.4 10 bp overlap

Motif DE_48h DE_48h-GABPA_MA0062.4 10 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 489 bp overlap

ChIP DE DE-GATA4-2 456 bp overlap

GATA6 5 datasets

ChIP DE DE-GATA6-1 450 bp overlap

ChIP DE DE-GATA6-2 458 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 266 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 271 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 261 bp overlap

HNF4A 2 datasets

Motif DE_36h DE_36h-HNF4A_MA1494.2 14 bp overlap

Motif DE_48h DE_48h-HNF4A_MA1494.2 14 bp overlap

HOXB2::ELK1 2 datasets

Motif DE_36h DE_36h-HOXB2ELK1_MA1957.1 14 bp overlap

Motif DE_48h DE_48h-HOXB2ELK1_MA1957.1 14 bp overlap

ID3 1 dataset

ChIP K-562 ENCSR005NMT.ID3.K-562 271 bp overlap

IKZF2 2 datasets

Motif DE_36h DE_36h-IKZF2_MA2326.1 6 bp overlap

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

IRF4 1 dataset

ChIP NCI-H929 GSE56857.IRF4.NCI-H929 85 bp overlap

Ikzf3 2 datasets

Motif DE_36h DE_36h-Ikzf3_MA1992.2 9 bp overlap

Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap

JUN 1 dataset

Motif DE_48h DE_48h-JUN_MA0488.2 10 bp overlap

JUND 1 dataset

Motif DE_48h DE_48h-JUND_MA0492.2 11 bp overlap

KLF17 1 dataset

Motif DE_48h DE_48h-KLF17_MA1514.2 14 bp overlap

KLF9 1 dataset

Motif DE_48h DE_48h-KLF9_MA1107.3 11 bp overlap

Lef1 1 dataset

Motif DE_48h DE_48h-Lef1_MA0768.3 8 bp overlap

MGA 2 datasets

Motif DE_48h DE_48h-MGA_MA0801.1 8 bp overlap

NHLH1 1 dataset

Motif DE_48h DE_48h-NHLH1_MA0048.3 9 bp overlap

NKX2-1 1 dataset

ChIP H9_derived-cIN GSE99937.NKX2-1.H9_derived-cIN 76 bp overlap

NR2C1 1 dataset

Motif DE_48h DE_48h-NR2C1_MA1535.2 6 bp overlap

NR2C2 1 dataset

Motif DE_48h DE_48h-NR2C2_MA1536.2 6 bp overlap

NR2F1 1 dataset

Motif DE_48h DE_48h-NR2F1_MA0017.3 12 bp overlap

NR4A1 2 datasets

ChIP Kasumi-1 GSE79491.NR4A1.Kasumi-1 360 bp overlap

ChIP MOLM-14_DHE GSE124963.NR4A1.MOLM-14_DHE 290 bp overlap

Neurod2 1 dataset

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Nr1H2 1 dataset

Motif DE_48h DE_48h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 1 dataset

Motif DE_48h DE_48h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 1 dataset

Motif DE_48h DE_48h-Nr1h3_MA2337.1 6 bp overlap

Nr2F6 2 datasets

Motif DE_36h DE_36h-Nr2F6_MA0728.1 15 bp overlap

Motif DE_48h DE_48h-Nr2F6_MA0728.1 15 bp overlap

Olig2 1 dataset

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

PLAG1 1 dataset

Motif DE_48h DE_48h-PLAG1_MA0163.1 14 bp overlap

RREB1 1 dataset

Motif DE_48h DE_48h-RREB1_MA0073.2 19 bp overlap

Rarb 2 datasets

Motif DE_36h DE_36h-Rarb_MA0857.1 16 bp overlap

Motif DE_48h DE_48h-Rarb_MA0857.1 16 bp overlap

Rarg 2 datasets

Motif DE_36h DE_36h-Rarg_MA0859.2 15 bp overlap

Motif DE_48h DE_48h-Rarg_MA0859.2 15 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 318 bp overlap

SMAD2_3 1 dataset

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 273 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 254 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 268 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 331 bp overlap

T 2 datasets

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 183 bp overlap

TBX1 1 dataset

Motif DE_48h DE_48h-TBX1_MA0805.1 8 bp overlap

TBX15 1 dataset

Motif DE_48h DE_48h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_48h DE_48h-TBX18_MA1565.2 9 bp overlap

TBX20 2 datasets

Motif DE_48h DE_48h-TBX20_MA0689.1 11 bp overlap

TBX21 2 datasets

Motif DE_36h DE_36h-TBX21_MA0690.3 10 bp overlap

Motif DE_48h DE_48h-TBX21_MA0690.3 10 bp overlap

TBX5 1 dataset

Motif DE_48h DE_48h-TBX5_MA0807.1 8 bp overlap

TP63 1 dataset

ChIP breast-organoid GSE113909.TP63.breast-organoid 181 bp overlap

TRIM28 1 dataset

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 209 bp overlap

Tbx6 2 datasets

Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap

Tcf12 1 dataset

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

ZBTB11 2 datasets

Motif DE_36h DE_36h-ZBTB11_MA2329.1 9 bp overlap

Motif DE_48h DE_48h-ZBTB11_MA2329.1 9 bp overlap

ZBTB14 1 dataset

Motif DE_48h DE_48h-ZBTB14_MA1650.2 8 bp overlap

ZBTB33 1 dataset

ChIP K-562 ENCSR876GXA.ZBTB33.K-562 254 bp overlap

ZBTB6 1 dataset

Motif DE_48h DE_48h-ZBTB6_MA1581.2 9 bp overlap

ZNF667 2 datasets

Motif DE_36h DE_36h-ZNF667_MA1984.2 11 bp overlap

Motif DE_48h DE_48h-ZNF667_MA1984.2 11 bp overlap