Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of DNA-templated transcription. Located in aggresome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:5,196,239–5,197,482 | 98.9 kb | Distal (>10kb) Multiome | 472 | |
| chr18:5,237,139–5,238,880 | 58.0 kb | Distal (>10kb) Multiome | 958 | |
| chr18:5,287,727–5,288,731 | 7.0 kb | Proximal (<10kb) | 74 | |
| chr18:5,294,279–5,297,100 | 229 bp | At TSS Multiome | 946 | |
| chr18:5,456,606–5,457,058 | 160.8 kb | Distal (>10kb) Multiome | 201 | |
| chr18:5,542,357–5,544,394 | 247.3 kb | Distal (>10kb) Multiome | 346 |
Genomic view of the ZBTB14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.