chr12 : 15,329,733 – 15,330,640

907 bp 73 TFs 1 linked gene

This 907 bp open chromatin element is linked to PTPRO and is bound by 73 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
PTPRO		6.9 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

73 transcription factors

AR 1 dataset

ChIP LNCaP GSE80256.AR.LNCaP 205 bp overlap

Arid3a 4 datasets

Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap

Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap

Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap

BARX1 1 dataset

Motif DE_60h DE_60h-BARX1_MA0875.2 6 bp overlap

BSX 1 dataset

Motif DE_60h DE_60h-BSX_MA0876.2 6 bp overlap

DLX1 1 dataset

Motif DE_60h DE_60h-DLX1_MA0879.3 6 bp overlap

DLX6 1 dataset

Motif DE_60h DE_60h-DLX6_MA0882.2 6 bp overlap

Dlx3 1 dataset

Motif DE_60h DE_60h-Dlx3_MA0880.2 6 bp overlap

Dlx4 1 dataset

Motif DE_60h DE_60h-Dlx4_MA0881.2 6 bp overlap

Dux 3 datasets

Motif DE_48h DE_48h-Dux_MA0611.3 11 bp overlap

Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap

Motif DE_72h DE_72h-Dux_MA0611.3 11 bp overlap

EN2 1 dataset

Motif DE_60h DE_60h-EN2_MA0642.3 7 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 154 bp overlap

ETV2::HOXB13 1 dataset

Motif DE_60h DE_60h-ETV2HOXB13_MA1943.2 13 bp overlap

EZH2 2 datasets

ChIP DND41 ENCSR000ASW.EZH2.DND41 69 bp overlap

ChIP LNCaP GSE39459.EZH2.LNCaP 195 bp overlap

Ebf4 1 dataset

Motif DE_60h DE_60h-Ebf4_MA2122.1 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 486 bp overlap

ChIP DE DE-FOXA2-2 517 bp overlap

GATA2 4 datasets

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 264 bp overlap

GATA3 1 dataset

ChIP SK-N-BE2-C GSE94822.GATA3.SK-N-BE2-C 146 bp overlap

GATA4 5 datasets

ChIP DE DE-GATA4-1 828 bp overlap

ChIP DE DE-GATA4-2 781 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

GATA5 3 datasets

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 13 datasets

ChIP AGS GSE51705.GATA6.AGS 140 bp overlap

ChIP DE DE-GATA6-1 663 bp overlap

ChIP DE DE-GATA6-2 801 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 312 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 512 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 259 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 587 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 581 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 435 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 659 bp overlap

GBX1 1 dataset

Motif DE_60h DE_60h-GBX1_MA0889.2 7 bp overlap

GBX2 1 dataset

Motif DE_60h DE_60h-GBX2_MA0890.2 6 bp overlap

GRHL2 1 dataset

Motif DE_60h DE_60h-GRHL2_MA1105.3 8 bp overlap

Gata3 3 datasets

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HESX1 1 dataset

Motif DE_60h DE_60h-HESX1_MA0894.2 6 bp overlap

HIF1A 1 dataset

ChIP U2OS_trough_DMOG GSE85096.HIF1A.U2OS_trough_DMOG 281 bp overlap

HOXA7 1 dataset

Motif DE_60h DE_60h-HOXA7_MA1498.3 6 bp overlap

Hmx1 1 dataset

Motif DE_60h DE_60h-Hmx1_MA0896.2 9 bp overlap

Hmx2 1 dataset

Motif DE_60h DE_60h-Hmx2_MA0897.2 15 bp overlap

Hnf1A 1 dataset

Motif DE_60h DE_60h-Hnf1A_MA1991.2 10 bp overlap

ISL1 1 dataset

ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 282 bp overlap

LBX1 1 dataset

Motif DE_60h DE_60h-LBX1_MA0618.2 7 bp overlap

LBX2 1 dataset

Motif DE_60h DE_60h-LBX2_MA0699.2 6 bp overlap

LHX2 1 dataset

Motif DE_60h DE_60h-LHX2_MA0700.3 6 bp overlap

LHX9 1 dataset

Motif DE_60h DE_60h-LHX9_MA0701.3 7 bp overlap

Lef1 1 dataset

Motif DE_60h DE_60h-Lef1_MA0768.3 8 bp overlap

Lhx3 1 dataset

Motif DE_60h DE_60h-Lhx3_MA0135.2 12 bp overlap

MAFF 4 datasets

Motif DE_48h DE_48h-MAFF_MA0495.4 11 bp overlap

Motif DE_60h DE_60h-MAFF_MA0495.4 11 bp overlap

Motif DE_72h DE_72h-MAFF_MA0495.4 11 bp overlap

MAFK 3 datasets

Motif DE_48h DE_48h-MAFK_MA0496.4 10 bp overlap

Motif DE_60h DE_60h-MAFK_MA0496.4 10 bp overlap

Motif DE_72h DE_72h-MAFK_MA0496.4 10 bp overlap

MITF 1 dataset

ChIP melanocyte_BRAFV600E GSE50681.MITF.melanocyte_BRAFV600E 210 bp overlap

MSX1 1 dataset

Motif DE_60h DE_60h-MSX1_MA0666.3 6 bp overlap

MSX2 1 dataset

Motif DE_60h DE_60h-MSX2_MA0708.3 6 bp overlap

Mafg 3 datasets

Motif DE_48h DE_48h-Mafg_MA0659.4 12 bp overlap

Motif DE_60h DE_60h-Mafg_MA0659.4 12 bp overlap

Motif DE_72h DE_72h-Mafg_MA0659.4 12 bp overlap

Msx3 1 dataset

Motif DE_60h DE_60h-Msx3_MA0709.2 6 bp overlap

NFIL3 1 dataset

Motif DE_60h DE_60h-NFIL3_MA0025.3 9 bp overlap

NR1H4::RXRA 1 dataset

Motif DE_60h DE_60h-NR1H4RXRA_MA1146.2 13 bp overlap

NR4A2::RXRA 1 dataset

Motif DE_60h DE_60h-NR4A2RXRA_MA1147.2 13 bp overlap

Nobox 1 dataset

Motif DE_60h DE_60h-Nobox_MA0125.2 6 bp overlap

PHOX2A 1 dataset

Motif DE_60h DE_60h-PHOX2A_MA0713.1 11 bp overlap

PHOX2B 1 dataset

Motif DE_60h DE_60h-PHOX2B_MA0681.3 12 bp overlap

POU3F3 1 dataset

Motif DE_60h DE_60h-POU3F3_MA0788.1 13 bp overlap

PROP1 1 dataset

Motif DE_60h DE_60h-PROP1_MA0715.1 11 bp overlap

PROX1 3 datasets

Motif DE_48h DE_48h-PROX1_MA0794.1 12 bp overlap

Motif DE_60h DE_60h-PROX1_MA0794.1 12 bp overlap

Motif DE_72h DE_72h-PROX1_MA0794.1 12 bp overlap

PRRX2 1 dataset

Motif DE_60h DE_60h-PRRX2_MA0075.4 7 bp overlap

RARA::RXRA 3 datasets

Motif DE_48h DE_48h-RARARXRA_MA0159.1 17 bp overlap

Motif DE_60h DE_60h-RARARXRA_MA0159.1 17 bp overlap

Motif DE_72h DE_72h-RARARXRA_MA0159.1 17 bp overlap

RAX 1 dataset

Motif DE_60h DE_60h-RAX_MA0718.2 6 bp overlap

Runx1 2 datasets

Motif DE_60h DE_60h-Runx1_MA0002.3 9 bp overlap

Motif DE_72h DE_72h-Runx1_MA0002.3 9 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 547 bp overlap

SMAD2_3 1 dataset

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 463 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 220 bp overlap

SPIB 1 dataset

ChIP OCI-Ly3_SHCTR GSE56857.SPIB.OCI-Ly3_SHCTR 200 bp overlap

TCF7 1 dataset

Motif DE_60h DE_60h-TCF7_MA0769.3 7 bp overlap

TCF7L1 1 dataset

Motif DE_60h DE_60h-TCF7L1_MA1421.1 12 bp overlap

TCF7L2 1 dataset

Motif DE_60h DE_60h-TCF7L2_MA0523.2 9 bp overlap

TRPS1 3 datasets

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ZFP14 2 datasets

Motif DE_60h DE_60h-ZFP14_MA1972.1 15 bp overlap

Motif DE_72h DE_72h-ZFP14_MA1972.1 15 bp overlap

ZKSCAN3 2 datasets

Motif DE_60h DE_60h-ZKSCAN3_MA1973.2 14 bp overlap

ZNF331 3 datasets

Motif DE_48h DE_48h-ZNF331_MA1726.2 10 bp overlap

Motif DE_60h DE_60h-ZNF331_MA1726.2 10 bp overlap

Motif DE_72h DE_72h-ZNF331_MA1726.2 10 bp overlap

ZNF558 1 dataset

Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap

ZNF582 1 dataset

Motif DE_60h DE_60h-ZNF582_MA1983.2 19 bp overlap

ZNF652 1 dataset

Motif DE_60h DE_60h-ZNF652_MA1657.2 9 bp overlap

ZNF680 1 dataset

Motif DE_60h DE_60h-ZNF680_MA1729.2 11 bp overlap

Zfp335 1 dataset

Motif DE_60h DE_60h-Zfp335_MA2002.2 7 bp overlap