chr12:8,635,736–8,636,521

chr12 : 8,635,736 – 8,636,521

785 bp 57 TFs 6 linked genes

This 785 bp open chromatin element is linked to 6 target genes and is bound by 57 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
RIMKLB		45.5 kb	Distal	Multiome
LINC02972		152.2 kb	Distal	Multiome
A2ML1		187.4 kb	Distal	Multiome
LINC00937		245.3 kb	Distal	Multiome
PHC1		277.8 kb	Distal	Multiome
ENSG00000282022		279.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

57 transcription factors

CTNNB1 1 dataset

ChIP hESC_YAP-_activinA_15h GSE99202.CTNNB1.hESC_YAP-_activinA_15h 122 bp overlap

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap

Dmbx1 2 datasets

Motif DE_60h DE_60h-Dmbx1_MA0883.2 10 bp overlap

Motif DE_72h DE_72h-Dmbx1_MA0883.2 10 bp overlap

ChIP H1 ENCFF785DWK 425 bp overlap

ERF::FOXI1 2 datasets

Motif DE_60h DE_60h-ERFFOXI1_MA1935.2 10 bp overlap

Motif DE_72h DE_72h-ERFFOXI1_MA1935.2 10 bp overlap

ChIP GM23338 ENCFF701IZH 306 bp overlap

FLI1::FOXI1 2 datasets

Motif DE_60h DE_60h-FLI1FOXI1_MA1950.2 11 bp overlap

Motif DE_72h DE_72h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 777 bp overlap

ChIP DE DE-FOXA2-2 434 bp overlap

FOXO1::ELK1 3 datasets

Motif DE_60h DE_60h-FOXO1ELK1_MA1954.2 13 bp overlap

Motif DE_72h DE_72h-FOXO1ELK1_MA1954.2 13 bp overlap

Motif DE_72h DE_72h-FOXO1ELK1_MA1954.2 13 bp overlap

GATA1 1 dataset

Motif DE_12h DE_12h-GATA1_MA0035.5 7 bp overlap

GATA1::TAL1 2 datasets

Motif DE_12h DE_12h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 1 dataset

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 785 bp overlap

ChIP DE DE-GATA4-2 785 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

GATA5 1 dataset

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 7 datasets

ChIP DE DE-GATA6-1 747 bp overlap

ChIP DE DE-GATA6-2 764 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 753 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 785 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 698 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 623 bp overlap

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap

GSC2 2 datasets

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap

Gata3 1 dataset

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HNF1B 1 dataset

ChIP foregut GSE117136.HNF1B.foregut 144 bp overlap

HOXB4 1 dataset

Motif DE_12h DE_12h-HOXB4_MA1499.2 6 bp overlap

HOXC4 1 dataset

Motif DE_12h DE_12h-HOXC4_MA1504.2 6 bp overlap

HOXD4 1 dataset

Motif DE_12h DE_12h-HOXD4_MA1507.2 6 bp overlap

IKZF1 3 datasets

Motif DE_60h DE_60h-IKZF1_MA1508.2 8 bp overlap

Motif DE_72h DE_72h-IKZF1_MA1508.2 8 bp overlap

Motif DE_72h DE_72h-IKZF1_MA1508.2 8 bp overlap

Motif DE_12h DE_12h-JDP2_MA0655.1 9 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 380 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 317 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 720 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 785 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 331 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 219 bp overlap

ChIP H1 ENCFF601FOM 288 bp overlap

ChIP H1 ENCFF601FOM 325 bp overlap

ChIP H1 ENCFF914VQY 238 bp overlap

ChIP WTC11 ENCFF223QFY 497 bp overlap

Motif DE_72h DE_72h-MYB_MA0100.4 6 bp overlap

NANOG 5 datasets

ChIP GM23338 ENCFF065NZG 302 bp overlap

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP GM23338 ENCFF065NZG 307 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 94 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 166 bp overlap

NKX6-1 1 dataset

Motif DE_12h DE_12h-NKX6-1_MA0674.2 7 bp overlap

NKX6-3 1 dataset

Motif DE_12h DE_12h-NKX6-3_MA1530.2 8 bp overlap

OTX1 2 datasets

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap

ChIP WTC11 ENCFF634NAO 63 bp overlap

PITX1 2 datasets

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap

PITX2 2 datasets

Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap

Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap

PITX3 2 datasets

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap

POLR2A 1 dataset

ChIP GM23338 ENCFF450WCS 425 bp overlap

POU5F1 1 dataset

ChIP DE_D1 DED1-OCT4_Batch_II 785 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 785 bp overlap

POU6F1 1 dataset

Motif DE_12h DE_12h-POU6F1_MA1549.2 7 bp overlap

POU6F2 1 dataset

Motif DE_12h DE_12h-POU6F2_MA0793.2 9 bp overlap

RHOXF1 2 datasets

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap

RREB1 2 datasets

Motif DE_60h DE_60h-RREB1_MA0073.2 19 bp overlap

Motif DE_72h DE_72h-RREB1_MA0073.2 19 bp overlap

SMAD2 2 datasets

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 119 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 77 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 163 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 785 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 785 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 785 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 785 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 703 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S15-DE-d1-BAF155-exp1 95 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 408 bp overlap

SPIC 3 datasets

Motif DE_60h DE_60h-SPIC_MA0687.2 13 bp overlap

Motif DE_72h DE_72h-SPIC_MA0687.2 13 bp overlap

Motif DE_72h DE_72h-SPIC_MA0687.2 13 bp overlap

TGIF2LX 2 datasets

Motif DE_60h DE_60h-TGIF2LX_MA1571.1 12 bp overlap

Motif DE_72h DE_72h-TGIF2LX_MA1571.1 12 bp overlap

TGIF2LY 2 datasets

Motif DE_60h DE_60h-TGIF2LY_MA1572.1 12 bp overlap

Motif DE_72h DE_72h-TGIF2LY_MA1572.1 12 bp overlap

TP63 3 datasets

ChIP SUIT-2 GSE115461.TP63.SUIT-2 106 bp overlap

ChIP keratinocyte GSE56674.TP63.keratinocyte 82 bp overlap

ChIP keratinocyte_CISP GSE56674.TP63.keratinocyte_CISP 89 bp overlap

TRERF1 1 dataset

ChIP WTC11 ENCFF113BUM 95 bp overlap

TRPS1 1 dataset

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ZNF184 2 datasets

Motif DE_60h DE_60h-ZNF184_MA2120.1 13 bp overlap

Motif DE_72h DE_72h-ZNF184_MA2120.1 13 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 82 bp overlap

ZNF532 1 dataset

ChIP WTC11 ENCFF373VBX 201 bp overlap

ZSCAN18 1 dataset

ChIP WTC11 ENCFF867QWX 51 bp overlap