This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for TRERF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRERF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRERF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:42,166,489–42,167,048 | 285.3 kb | Distal (>10kb) Multiome | 451 | |
| chr6:42,177,902–42,178,547 | 273.8 kb | Distal (>10kb) Multiome | 161 | |
| chr6:42,260,672–42,261,201 | 191.0 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr6:42,450,521–42,450,790 | 470 bp | At TSS | 76 | |
| chr6:42,451,208–42,454,840 | 199 bp | At TSS Multiome | 808 | |
| chr6:42,547,405–42,547,886 | 95.7 kb | Distal (>10kb) Multiome HiCAR | 570 | |
| chr6:42,563,541–42,564,644 | 112.0 kb | Distal (>10kb) Multiome | 1040 | |
| chr6:42,710,310–42,710,904 | 258.5 kb | Distal (>10kb) Multiome | 100 | |
| chr6:42,745,261–42,747,361 | 294.1 kb | Distal (>10kb) Multiome | 1101 |
Genomic view of the TRERF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.