Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZSCAN18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSCAN18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSCAN18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,803,547–57,804,316 | 294.3 kb | Distal (>10kb) Multiome | 206 | |
| chr19:57,804,773–57,805,214 | 293.2 kb | Distal (>10kb) Multiome | 37 | |
| chr19:57,810,480–57,811,177 | 287.4 kb | Distal (>10kb) Multiome | 180 | |
| chr19:57,814,439–57,815,270 | 283.2 kb | Distal (>10kb) Multiome | 692 | |
| chr19:57,819,268–57,819,991 | 278.6 kb | Distal (>10kb) Multiome | 734 | |
| chr19:57,829,187–57,830,712 | 267.9 kb | Distal (>10kb) Multiome | 321 | |
| chr19:57,849,421–57,850,221 | 248.5 kb | Distal (>10kb) Multiome | 291 | |
| chr19:57,887,264–57,887,897 | 210.6 kb | Distal (>10kb) Multiome | 47 | |
| chr19:57,888,389–57,889,457 | 209.2 kb | Distal (>10kb) Multiome | 322 | |
| chr19:57,916,199–57,917,124 | 181.5 kb | Distal (>10kb) Multiome | 535 | |
| chr19:57,934,907–57,935,617 | 162.9 kb | Distal (>10kb) Multiome | 259 | |
| chr19:57,947,388–57,948,012 | 150.4 kb | Distal (>10kb) Multiome | 675 | |
| chr19:58,002,336–58,003,368 | 95.4 kb | Distal (>10kb) Multiome | 830 | |
| chr19:58,059,066–58,059,937 | 38.8 kb | Distal (>10kb) Multiome | 284 | |
| chr19:58,097,783–58,098,870 | 104 bp | At TSS Multiome | 458 | |
| chr19:58,150,278–58,150,941 | 52.5 kb | Distal (>10kb) Multiome | 533 | |
| chr19:58,154,448–58,155,527 | 56.9 kb | Distal (>10kb) Multiome | 802 | |
| chr19:58,182,544–58,183,906 | 85.0 kb | Distal (>10kb) Multiome | 1019 | |
| chr19:58,228,362–58,229,199 | 130.7 kb | Distal (>10kb) Multiome | 706 | |
| chr19:58,278,271–58,279,774 | 180.6 kb | Distal (>10kb) Multiome | 950 | |
| chr19:58,304,887–58,305,868 | 207.1 kb | Distal (>10kb) Multiome | 858 | |
| chr19:58,326,789–58,327,710 | 228.8 kb | Distal (>10kb) Multiome | 985 | |
| chr19:58,347,086–58,347,987 | 249.4 kb | Distal (>10kb) Multiome | 467 | |
| chr19:58,356,174–58,356,775 | 258.3 kb | Distal (>10kb) Multiome | 101 | |
| chr19:58,361,859–58,363,243 | 264.5 kb | Distal (>10kb) Multiome | 972 | |
| chr19:58,380,269–58,381,636 | 282.9 kb | Distal (>10kb) Multiome | 1044 | |
| chr19:58,386,311–58,387,531 | 288.9 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:58,395,438–58,396,606 | 297.5 kb | Distal (>10kb) Multiome | 448 |
Genomic view of the ZSCAN18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.