chr6:32,144,531–32,145,041

chr6 : 32,144,531 – 32,145,041

510 bp 44 TFs 19 linked genes

This 510 bp open chromatin element is linked to 19 target genes and is bound by 44 transcription factors.

Linked Genes

19 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PRRT1		6.9 kb	Proximal	Proximity
PPT2		8.5 kb	Proximal	Proximity
ENSG00000284954		8.9 kb	Proximal	Proximity
ENSG00000285085		8.9 kb	Proximal	Proximity
PPT2-EGFL8		9.0 kb	Proximal	Proximity
ATF6B		16.5 kb	Distal	Multiome
EGFL8		22.8 kb	Distal	Multiome
TNXB		29.4 kb	Distal	Multiome
AGPAT1		33.4 kb	Distal	Multiome
RNF5		33.7 kb	Distal	Multiome
AGER		39.5 kb	Distal	Multiome
PBX2		45.2 kb	Distal	Multiome
TSBP1-AS1		110.3 kb	Distal	Multiome
STK19		172.4 kb	Distal	Multiome
DXO		172.5 kb	Distal	Multiome
SKIC2		185.6 kb	Distal	Multiome
NELFE		185.8 kb	Distal	Multiome
EHMT2		247.0 kb	Distal	Multiome
NEU1		281.8 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

44 transcription factors

ChIP MCF-7_TCDD_45min GSE90550.AHR.MCF-7_TCDD_45min 212 bp overlap

ARID1A 2 datasets

ChIP MCF-7_4-hydroxytamoxifen GSE123284.ARID1A.MCF-7_4-hydroxytamoxifen 271 bp overlap

ChIP MCF-7_DCDT GSE123284.ARID1A.MCF-7_DCDT 182 bp overlap

CEBPB 1 dataset

ChIP HeLa-S3 ENCFF722WEG 51 bp overlap

CTBP1 1 dataset

ChIP MCF-7 ENCSR636EYA.CTBP1.MCF-7 195 bp overlap

CTBP2 1 dataset

ChIP MCF-7 GSE107013.CTBP2.MCF-7 198 bp overlap

ESR1 19 datasets

ChIP MCF-7_ARID1A-KO_4-OHT GSE123284.ESR1.MCF-7_ARID1A-KO_4-OHT 283 bp overlap

ChIP MCF-7_D538G_DMSO GSE148277.ESR1.MCF-7_D538G_DMSO 276 bp overlap

ChIP MCF-7_E2+4OHT_SRC-3 GSE119702.ESR1.MCF-7_E2+4OHT_SRC-3 154 bp overlap

ChIP MCF-7_E2-20min-ERalpha GSE94023.ESR1.MCF-7_E2-20min-ERalpha 72 bp overlap

ChIP MCF-7_E2_45min GSE109820.ESR1.MCF-7_E2_45min 186 bp overlap

ChIP MCF-7_E2_talen GSE94493.ESR1.MCF-7_E2_talen 167 bp overlap

ChIP MCF-7_Fulvestrant_HC11 GSE102882.ESR1.MCF-7_Fulvestrant_HC11 247 bp overlap

ChIP MCF-7_HC11 GSE102882.ESR1.MCF-7_HC11 255 bp overlap

ChIP MCF-7_RAD001 GSE103023.ESR1.MCF-7_RAD001 212 bp overlap

ChIP MCF-7_SRC3_OHT GSE119702.ESR1.MCF-7_SRC3_OHT 154 bp overlap

ChIP MCF-7_estradiol-DHT_4h GSE99626.ESR1.MCF-7_estradiol-DHT_4h 72 bp overlap

ChIP MCF-7_estradiol_4h GSE99626.ESR1.MCF-7_estradiol_4h 195 bp overlap

ChIP MCF-7_parental GSE123284.ESR1.MCF-7_parental 424 bp overlap

ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.ESR1.MCF-7_parental_4-hydroxytamoxifen 330 bp overlap

ChIP MCF-7_shFbxo_E2_4OHT GSE119702.ESR1.MCF-7_shFbxo_E2_4OHT 172 bp overlap

ChIP MCF-7_shFbxo_OHT GSE119702.ESR1.MCF-7_shFbxo_OHT 172 bp overlap

ChIP MDA-MB-134-VI_E2 GSE109103.ESR1.MDA-MB-134-VI_E2 480 bp overlap

ChIP MDA-MB-134-VI_FI GSE109103.ESR1.MDA-MB-134-VI_FI 251 bp overlap

ChIP breast-cancer_3487 GSE126004.ESR1.breast-cancer_3487 222 bp overlap

ESR1_D538G 1 dataset

ChIP MCF-7_dox_E2 GSE94493.ESR1_D538G.MCF-7_dox_E2 260 bp overlap

ESR1_Y537S 2 datasets

ChIP MCF-7_E2 GSE94493.ESR1_Y537S.MCF-7_E2 285 bp overlap

ChIP MCF-7_dox GSE94493.ESR1_Y537S.MCF-7_dox 343 bp overlap

ChIP DND41 ENCSR000ASW.EZH2.DND41 295 bp overlap

FOXA1 2 datasets

ChIP MCF-7 GSE81714.FOXA1.MCF-7 242 bp overlap

ChIP breast-cancer_3487 GSE126004.FOXA1.breast-cancer_3487 333 bp overlap

FOXA2 3 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 289 bp overlap

ChIP DE DE-FOXA2-1 510 bp overlap

ChIP DE DE-FOXA2-2 510 bp overlap

GATA1 4 datasets

ChIP K-562 GSE107726.GATA1.K-562 244 bp overlap

ChIP K-562 ENCSR000EFT.GATA1.K-562 160 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 235 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 226 bp overlap

GATA2 4 datasets

ChIP K-562 ENCSR000DKA.GATA2.K-562 250 bp overlap

ChIP K-562 ENCSR000EWG.GATA2.K-562 116 bp overlap

ChIP VCaP_JQ1 GSE125236.GATA2.VCaP_JQ1 138 bp overlap

ChIP primary-endometrial-stromal-cell_Veh_P2 GSE145673.GATA2.primary-endometrial-stromal-cell_Veh_P2 295 bp overlap

GATA3 10 datasets

ChIP MCF-7 ENCFF352QVM 250 bp overlap

ChIP MCF-7 ENCFF437NQS 129 bp overlap

ChIP MCF-7 GSE122847.GATA3.MCF-7 291 bp overlap

ChIP MCF-7 GSE133072.GATA3.MCF-7 327 bp overlap

ChIP MCF-7 ENCSR000EWS.GATA3.MCF-7 258 bp overlap

ChIP MCF-7_E2 GSE81510.GATA3.MCF-7_E2 211 bp overlap

ChIP MCF-7_E2_Dex GSE81510.GATA3.MCF-7_E2_Dex 349 bp overlap

ChIP MCF-7_sgScr GSE133072.GATA3.MCF-7_sgScr 331 bp overlap

ChIP T-47D ENCSR000BMX.GATA3.T-47D 153 bp overlap

ChIP T-47D_sc GSE122847.GATA3.T-47D_sc 216 bp overlap

GATA3_Cter 1 dataset

ChIP T-47D_CR3flp GSE99479.GATA3_Cter.T-47D_CR3flp 136 bp overlap

GATA3_Nter 1 dataset

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 163 bp overlap

GATA4 6 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 236 bp overlap

ChIP DE DE-GATA4-1 510 bp overlap

ChIP DE DE-GATA4-2 510 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 184 bp overlap

ChIP foregut GSE117136.GATA4.foregut 501 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 447 bp overlap

GATA6 12 datasets

ChIP DE DE-GATA6-1 510 bp overlap

ChIP DE DE-GATA6-2 510 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 510 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 510 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 510 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 510 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 510 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 510 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 489 bp overlap

ChIP foregut GSE117136.GATA6.foregut 373 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 362 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 277 bp overlap

GFI1B 1 dataset

ChIP K-562 ENCSR509GDT.GFI1B.K-562 151 bp overlap

HDAC1 3 datasets

ChIP K-562 ENCSR387UWP.HDAC1.K-562 160 bp overlap

ChIP MCF-7_parental GSE123284.HDAC1.MCF-7_parental 199 bp overlap

ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.HDAC1.MCF-7_parental_4-hydroxytamoxifen 328 bp overlap

IKZF1 1 dataset

ChIP K-562 ENCSR395HWC.IKZF1.K-562 141 bp overlap

KDM1A 1 dataset

ChIP pancreatic-progenitor_GT GSE104840.KDM1A.pancreatic-progenitor_GT 291 bp overlap

ChIP HEK293 ENCSR859BMR.KLF1.HEK293 105 bp overlap

ChIP K562 ENCFF731XJJ 55 bp overlap

ChIP K-562 ENCSR807BGP.MTA1.K-562 124 bp overlap

NR2F2 2 datasets

ChIP MCF-7 ENCSR000BUY.NR2F2.MCF-7 130 bp overlap

ChIP MCF-7_E2 GSE132432.NR2F2.MCF-7_E2 71 bp overlap

ChIP breast_tumor_Male_28 GSE104399.PGR.breast_tumor_Male_28 351 bp overlap

POLR2A 2 datasets

ChIP stomach ENCFF820WZN 52 bp overlap

ChIP vagina ENCFF305NWS 117 bp overlap

PRDM10 1 dataset

ChIP HEK293 ENCFF145WQQ 168 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 471 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 417 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 269 bp overlap

SMARCA4 2 datasets

ChIP MCF-7 GSE123284.SMARCA4.MCF-7 231 bp overlap

ChIP MCF-7_parental GSE123284.SMARCA4.MCF-7_parental 250 bp overlap

SMARCB1 2 datasets

ChIP MCF-7_DCDT GSE123284.SMARCB1.MCF-7_DCDT 127 bp overlap

ChIP MCF-7_estrogen GSE123284.SMARCB1.MCF-7_estrogen 149 bp overlap

SNAI2 1 dataset

ChIP PC-9_2DF GSE131687.SNAI2.PC-9_2DF 245 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 372 bp overlap

SPDEF 2 datasets

ChIP MCF-7 ENCFF827PZY 102 bp overlap

ChIP MCF-7 ENCSR042GSX.SPDEF.MCF-7 105 bp overlap

STAT3 1 dataset

ChIP breast-cancer_3487 GSE126004.STAT3.breast-cancer_3487 249 bp overlap

TEAD4 1 dataset

ChIP PC-9_2DF_DMSO GSE131687.TEAD4.PC-9_2DF_DMSO 197 bp overlap

TRPS1 2 datasets

ChIP MCF-7 GSE133072.TRPS1.MCF-7 212 bp overlap

ChIP T-47D GSE107013.TRPS1.T-47D 148 bp overlap

YY1AP1 5 datasets

ChIP MCF-7_Veh GSE125594.YY1AP1.MCF-7_Veh 254 bp overlap

ChIP PC-9_1DF GSE131687.YY1AP1.PC-9_1DF 388 bp overlap

ChIP PC-9_1DF_DMSO GSE131687.YY1AP1.PC-9_1DF_DMSO 153 bp overlap

ChIP PC-9_2DF GSE131687.YY1AP1.PC-9_2DF 484 bp overlap

ChIP PC-9_2DF_DMSO GSE131687.YY1AP1.PC-9_2DF_DMSO 238 bp overlap

ZBTB17 1 dataset

ChIP HEK293 ENCFF865LIO 360 bp overlap

ZEB2 3 datasets

ChIP K-562 ENCSR004GKA.ZEB2.K-562 466 bp overlap

ChIP K-562 ENCSR322CFO.ZEB2.K-562 379 bp overlap

ChIP K562 ENCFF795CMH 358 bp overlap

ZNF121 6 datasets

ChIP HEK293 ENCFF839FUF 324 bp overlap

ChIP HEK293 ENCFF839FUF 122 bp overlap

ChIP HEK293 ENCSR224QDY.ZNF121.HEK293 222 bp overlap

ChIP HEK293 GSE76494.ZNF121.HEK293 213 bp overlap

ChIP Hep-G2 ENCSR945QEW.ZNF121.Hep-G2 226 bp overlap

ChIP HepG2 ENCFF343YSL 329 bp overlap

ZNF335 1 dataset

ChIP HEK293 ENCSR328SUD.ZNF335.HEK293 361 bp overlap