The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for ATF6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATF6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATF6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:31,826,770–31,828,135 | 300.7 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:31,834,277–31,835,371 | 293.5 kb | Distal (>10kb) Multiome | 1085 | |
| chr6:31,862,148–31,864,173 | 265.3 kb | Distal (>10kb) Multiome | 1118 | |
| chr6:31,896,965–31,898,037 | 230.6 kb | Distal (>10kb) Multiome | 654 | |
| chr6:31,901,114–31,902,643 | 226.0 kb | Distal (>10kb) Multiome | 826 | |
| chr6:31,958,527–31,959,598 | 169.2 kb | Distal (>10kb) Multiome | 953 | |
| chr6:31,971,421–31,972,872 | 155.9 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:32,048,217–32,048,679 | 79.9 kb | Distal (>10kb) Multiome | 611 | |
| chr6:32,087,265–32,088,160 | 40.4 kb | Distal (>10kb) Multiome | 473 | |
| chr6:32,118,897–32,119,107 | 8.7 kb | Proximal (<10kb) | 417 | |
| chr6:32,127,621–32,128,720 | 44 bp | At TSS Multiome | 683 | |
| chr6:32,129,973–32,130,800 | 2.2 kb | Proximal (<10kb) Multiome | 717 | |
| chr6:32,144,531–32,145,041 | 16.5 kb | Distal (>10kb) Multiome | 44 | |
| chr6:32,148,431–32,149,344 | 20.6 kb | Distal (>10kb) Multiome | 145 | |
| chr6:32,153,307–32,155,059 | 25.8 kb | Distal (>10kb) Multiome | 908 | |
| chr6:32,167,399–32,168,187 | 39.8 kb | Distal (>10kb) Multiome HiCAR | 411 | |
| chr6:32,175,673–32,176,347 | 47.9 kb | Distal (>10kb) Multiome | 654 | |
| chr6:32,177,078–32,178,952 | 49.8 kb | Distal (>10kb) Multiome | 820 | |
| chr6:32,190,108–32,191,167 | 62.1 kb | Distal (>10kb) Multiome | 661 | |
| chr6:32,195,084–32,196,878 | 67.6 kb | Distal (>10kb) Multiome | 1063 | |
| chr6:32,255,200–32,255,686 | 127.1 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the ATF6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.