RNF5
ring finger protein 5 | G16, NG2, RING5, RMA1

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.22
Biological processes 30 terms
ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum mannose trimming (GO:1904380)endoplasmic reticulum mannose trimming (GO:1904380)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum quality control compartment (GO:0044322)identical protein binding (GO:0042802)membrane (GO:0016020)mitochondrial membrane (GO:0031966)plasma membrane (GO:0005886)protein K48-linked ubiquitination (GO:0070936)protein K63-linked ubiquitination (GO:0070534)protein binding (GO:0005515)protein catabolic process (GO:0030163)protein ubiquitination (GO:0016567)protein-containing complex binding (GO:0044877)transmembrane transport (GO:0055085)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-like protein conjugating enzyme binding (GO:0044390)ubiquitin-protein transferase activity (GO:0004842)zinc ion binding (GO:0008270)
Expression (TPM)
RNF5 — as a Regulated Gene

TFs regulating RNF5 0 TFs

Transcription factors with Perturb-seq knockdown data for RNF5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RNF5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:31,896,965–31,898,037 280.8 kb Distal (>10kb) Multiome 654
chr6:31,901,114–31,902,643 276.2 kb Distal (>10kb) Multiome 826
chr6:31,958,527–31,959,598 219.4 kb Distal (>10kb) Multiome 953
chr6:31,971,421–31,972,872 206.2 kb Distal (>10kb) Multiome 1059
chr6:32,048,217–32,048,679 130.1 kb Distal (>10kb) Multiome 611
chr6:32,087,265–32,088,160 90.7 kb Distal (>10kb) Multiome 473
chr6:32,127,621–32,128,720 50.2 kb Distal (>10kb) Multiome 683
chr6:32,129,973–32,130,800 48.1 kb Distal (>10kb) Multiome 717
chr6:32,144,531–32,145,041 33.7 kb Distal (>10kb) Multiome 44
chr6:32,148,431–32,149,344 29.6 kb Distal (>10kb) Multiome 145
chr6:32,153,307–32,155,059 24.4 kb Distal (>10kb) Multiome 908
chr6:32,167,399–32,168,187 10.4 kb Distal (>10kb) Multiome 411
chr6:32,175,673–32,176,347 2.3 kb Proximal (<10kb) Multiome 654
chr6:32,177,078–32,178,952 432 bp At TSS Multiome 820
chr6:32,190,108–32,191,167 11.9 kb Distal (>10kb) Multiome 661
chr6:32,195,084–32,196,878 17.4 kb Distal (>10kb) Multiome 1063
chr6:32,255,200–32,255,686 76.9 kb Distal (>10kb) Multiome 364

Genome Browser

Genomic view of the RNF5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:31,886,965 – 32,265,686
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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