This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNXB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNXB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNXB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:31,814,125–31,815,936 | 300.0 kb | Distal (>10kb) Multiome | 822 | |
| chr6:31,818,020–31,818,663 | 297.0 kb | Distal (>10kb) Multiome | 280 | |
| chr6:31,821,306–31,822,544 | 293.3 kb | Distal (>10kb) Multiome | 714 | |
| chr6:31,826,770–31,828,135 | 287.8 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:31,834,277–31,835,371 | 280.6 kb | Distal (>10kb) Multiome | 1085 | |
| chr6:31,862,148–31,864,173 | 252.4 kb | Distal (>10kb) Multiome | 1118 | |
| chr6:31,896,965–31,898,037 | 217.7 kb | Distal (>10kb) Multiome | 654 | |
| chr6:31,901,114–31,902,643 | 213.1 kb | Distal (>10kb) Multiome | 826 | |
| chr6:31,958,527–31,959,598 | 156.3 kb | Distal (>10kb) Multiome | 953 | |
| chr6:31,971,421–31,972,872 | 143.1 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:32,048,217–32,048,679 | 67.0 kb | Distal (>10kb) Multiome | 611 | |
| chr6:32,087,265–32,088,160 | 27.6 kb | Distal (>10kb) Multiome | 473 | |
| chr6:32,118,897–32,119,107 | 3.6 kb | Proximal (<10kb) | 417 | |
| chr6:32,127,621–32,128,720 | 12.9 kb | Distal (>10kb) Multiome | 683 | |
| chr6:32,129,973–32,130,800 | 15.0 kb | Distal (>10kb) Multiome | 717 | |
| chr6:32,144,531–32,145,041 | 29.4 kb | Distal (>10kb) Multiome | 44 | |
| chr6:32,148,431–32,149,344 | 33.5 kb | Distal (>10kb) Multiome | 145 | |
| chr6:32,153,307–32,155,059 | 38.7 kb | Distal (>10kb) Multiome HiCAR | 908 | |
| chr6:32,167,399–32,168,187 | 52.7 kb | Distal (>10kb) Multiome HiCAR | 411 | |
| chr6:32,175,673–32,176,347 | 60.8 kb | Distal (>10kb) Multiome | 654 | |
| chr6:32,177,078–32,178,952 | 62.7 kb | Distal (>10kb) Multiome | 820 | |
| chr6:32,190,108–32,191,167 | 75.0 kb | Distal (>10kb) Multiome | 661 | |
| chr6:32,195,084–32,196,878 | 80.5 kb | Distal (>10kb) Multiome | 1063 | |
| chr6:32,255,200–32,255,686 | 140.0 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the TNXB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.