This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STK19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:31,682,887–31,683,880 | 289.0 kb | Distal (>10kb) Multiome | 248 | |
| chr6:31,702,816–31,703,520 | 269.0 kb | Distal (>10kb) Multiome | 875 | |
| chr6:31,713,576–31,714,641 | 258.2 kb | Distal (>10kb) Multiome | 171 | |
| chr6:31,728,852–31,730,814 | 242.1 kb | Distal (>10kb) Multiome | 979 | |
| chr6:31,739,236–31,740,741 | 232.4 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:31,766,045–31,766,778 | 205.9 kb | Distal (>10kb) Multiome | 351 | |
| chr6:31,795,097–31,796,366 | 176.4 kb | Distal (>10kb) Multiome | 979 | |
| chr6:31,806,162–31,807,183 | 165.4 kb | Distal (>10kb) Multiome | 947 | |
| chr6:31,814,125–31,815,936 | 157.7 kb | Distal (>10kb) Multiome | 822 | |
| chr6:31,818,020–31,818,663 | 154.0 kb | Distal (>10kb) Multiome | 280 | |
| chr6:31,821,306–31,822,544 | 150.3 kb | Distal (>10kb) Multiome | 714 | |
| chr6:31,826,770–31,828,135 | 144.8 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:31,834,277–31,835,371 | 137.6 kb | Distal (>10kb) Multiome | 1085 | |
| chr6:31,862,148–31,864,173 | 109.4 kb | Distal (>10kb) Multiome | 1118 | |
| chr6:31,896,965–31,898,037 | 74.8 kb | Distal (>10kb) Multiome | 654 | |
| chr6:31,901,114–31,902,643 | 70.1 kb | Distal (>10kb) Multiome | 826 | |
| chr6:31,958,527–31,959,598 | 13.3 kb | Distal (>10kb) Multiome | 953 | |
| chr6:31,971,421–31,972,872 | 57 bp | At TSS Multiome | 1059 | |
| chr6:32,048,217–32,048,679 | 76.0 kb | Distal (>10kb) Multiome | 611 | |
| chr6:32,087,265–32,088,160 | 115.4 kb | Distal (>10kb) Multiome | 473 | |
| chr6:32,127,621–32,128,720 | 155.9 kb | Distal (>10kb) Multiome | 683 | |
| chr6:32,129,973–32,130,800 | 158.0 kb | Distal (>10kb) Multiome | 717 | |
| chr6:32,144,531–32,145,041 | 172.4 kb | Distal (>10kb) Multiome | 44 | |
| chr6:32,148,431–32,149,344 | 176.5 kb | Distal (>10kb) Multiome | 145 | |
| chr6:32,153,307–32,155,059 | 181.7 kb | Distal (>10kb) Multiome | 908 | |
| chr6:32,167,399–32,168,187 | 195.7 kb | Distal (>10kb) Multiome | 411 | |
| chr6:32,175,673–32,176,347 | 203.8 kb | Distal (>10kb) Multiome | 654 | |
| chr6:32,177,078–32,178,952 | 205.7 kb | Distal (>10kb) Multiome | 820 | |
| chr6:32,190,108–32,191,167 | 218.0 kb | Distal (>10kb) Multiome | 661 | |
| chr6:32,195,084–32,196,878 | 223.5 kb | Distal (>10kb) Multiome | 1063 | |
| chr6:32,255,200–32,255,686 | 283.0 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the STK19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.