This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AGPAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGPAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGPAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:31,896,965–31,898,037 | 280.5 kb | Distal (>10kb) Multiome | 654 | |
| chr6:31,901,114–31,902,643 | 275.9 kb | Distal (>10kb) Multiome | 826 | |
| chr6:31,958,527–31,959,598 | 219.0 kb | Distal (>10kb) Multiome | 953 | |
| chr6:31,971,421–31,972,872 | 205.8 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:32,048,217–32,048,679 | 129.7 kb | Distal (>10kb) Multiome | 611 | |
| chr6:32,087,265–32,088,160 | 90.3 kb | Distal (>10kb) Multiome | 473 | |
| chr6:32,127,621–32,128,720 | 49.8 kb | Distal (>10kb) Multiome | 683 | |
| chr6:32,129,973–32,130,800 | 47.7 kb | Distal (>10kb) Multiome | 717 | |
| chr6:32,144,531–32,145,041 | 33.4 kb | Distal (>10kb) Multiome | 44 | |
| chr6:32,148,431–32,149,344 | 29.3 kb | Distal (>10kb) Multiome | 145 | |
| chr6:32,153,307–32,155,059 | 24.1 kb | Distal (>10kb) Multiome | 908 | |
| chr6:32,166,906–32,167,250 | 8.8 kb | Proximal (<10kb) | 146 | |
| chr6:32,167,399–32,168,187 | 10.1 kb | Distal (>10kb) Multiome | 411 | |
| chr6:32,175,673–32,176,347 | 2.0 kb | Proximal (<10kb) Multiome | 654 | |
| chr6:32,177,078–32,178,952 | 92 bp | At TSS Multiome | 820 | |
| chr6:32,190,108–32,191,167 | 12.3 kb | Distal (>10kb) Multiome | 661 | |
| chr6:32,195,084–32,196,878 | 17.7 kb | Distal (>10kb) Multiome | 1063 | |
| chr6:32,255,200–32,255,686 | 77.2 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the AGPAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.