AGER

AGER

advanced glycosylation end-product specific receptor | RAGE, SCARJ1, sRAGE

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

Developmental clusters: GC2 GC6

Biological processes 113 terms

DNA binding (GO:0003677)RNA binding (GO:0003723)S100 protein binding (GO:0044548)S100 protein binding (GO:0044548)advanced glycation end-product receptor activity (GO:0050785)amyloid-beta binding (GO:0001540)amyloid-beta binding (GO:0001540)amyloid-beta binding (GO:0001540)amyloid-beta binding (GO:0001540)apical plasma membrane (GO:0016324)astrocyte activation (GO:0048143)astrocyte development (GO:0014002)cell junction (GO:0030054)cell surface (GO:0009986)cell surface (GO:0009986)cell surface (GO:0009986)cell surface receptor signaling pathway (GO:0007166)cell surface receptor signaling pathway (GO:0007166)cellular response to amyloid-beta (GO:1904646)cellular response to amyloid-beta (GO:1904646)cellular response to glucose stimulus (GO:0071333)early endosome (GO:0005769)extracellular region (GO:0005576)extracellular region (GO:0005576)glucose mediated signaling pathway (GO:0010255)histone binding (GO:0042393)identical protein binding (GO:0042802)inflammatory response (GO:0006954)intracellular signal transduction (GO:0035556)learning or memory (GO:0007611)learning or memory (GO:0007611)microglial cell activation (GO:0001774)microglial cell activation (GO:0001774)microglial cell activation (GO:0001774)microglial cell activation (GO:0001774)molecular adaptor activity (GO:0060090)negative regulation of blood circulation (GO:1903523)negative regulation of blood circulation (GO:1903523)negative regulation of interleukin-10 production (GO:0032693)negative regulation of long-term synaptic depression (GO:1900453)negative regulation of long-term synaptic potentiation (GO:1900272)negative regulation of long-term synaptic potentiation (GO:1900272)negative regulation of long-term synaptic potentiation (GO:1900272)negative regulation of long-term synaptic potentiation (GO:1900272)negative regulation of multicellular organismal process (GO:0051241)neuron projection development (GO:0031175)neuron projection development (GO:0031175)neuron projection development (GO:0031175)nucleus (GO:0005634)nucleus (GO:0005634)phagocytic cup (GO:0001891)phagocytic cup (GO:0001891)phagocytosis (GO:0006909)phagocytosis (GO:0006909)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of DNA metabolic process (GO:0051054)positive regulation of DNA-templated DNA replication (GO:2000105)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of JNK cascade (GO:0046330)positive regulation of activated T cell proliferation (GO:0042104)positive regulation of amyloid precursor protein catabolic process (GO:1902993)positive regulation of cell differentiation (GO:0045597)positive regulation of cell migration (GO:0030335)positive regulation of cell population proliferation (GO:0008284)positive regulation of chemokine production (GO:0032722)positive regulation of chemokine production (GO:0032722)positive regulation of cytokine production (GO:0001819)positive regulation of dendritic cell differentiation (GO:2001200)positive regulation of double-strand break repair (GO:2000781)positive regulation of endothelin production (GO:1904472)positive regulation of endothelin production (GO:1904472)positive regulation of heterotypic cell-cell adhesion (GO:0034116)positive regulation of interleukin-1 beta production (GO:0032731)positive regulation of interleukin-1 beta production (GO:0032731)positive regulation of interleukin-12 production (GO:0032735)positive regulation of interleukin-6 production (GO:0032755)positive regulation of interleukin-6 production (GO:0032755)positive regulation of monocyte extravasation (GO:2000439)positive regulation of non-canonical NF-kappaB signal transduction (GO:1901224)positive regulation of p38MAPK cascade (GO:1900745)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of tumor necrosis factor production (GO:0032760)postsynapse (GO:0098794)protein binding (GO:0005515)protein-containing complex binding (GO:0044877)regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)regulation of T cell mediated cytotoxicity (GO:0001914)regulation of cell adhesion (GO:0030155)regulation of inflammatory response (GO:0050727)regulation of long-term synaptic potentiation (GO:1900271)regulation of long-term synaptic potentiation (GO:1900271)regulation of non-canonical NF-kappaB signal transduction (GO:1901222)regulation of p38MAPK cascade (GO:1900744)regulation of p38MAPK cascade (GO:1900744)regulation of spontaneous synaptic transmission (GO:0150003)regulation of synaptic plasticity (GO:0048167)response to amyloid-beta (GO:1904645)response to amyloid-beta (GO:1904645)response to amyloid-beta (GO:1904645)response to wounding (GO:0009611)scavenger receptor activity (GO:0005044)signaling receptor activity (GO:0038023)signaling receptor activity (GO:0038023)signaling receptor activity (GO:0038023)transcytosis (GO:0045056)transcytosis (GO:0045056)transmembrane signaling receptor activity (GO:0004888)transport across blood-brain barrier (GO:0150104)transport across blood-brain barrier (GO:0150104)

Expression (TPM)

TFs regulating AGER 0 TFs

Transcription factors with Perturb-seq knockdown data for AGER. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGER upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to AGER

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGER, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr6:31,896,965–31,898,037	286.7 kb	Distal (>10kb) Multiome	654
	chr6:31,901,114–31,902,643	282.0 kb	Distal (>10kb) Multiome	826
	chr6:31,958,527–31,959,598	225.2 kb	Distal (>10kb) Multiome	953
	chr6:31,971,421–31,972,872	212.0 kb	Distal (>10kb) Multiome	1059
	chr6:32,048,217–32,048,679	135.9 kb	Distal (>10kb) Multiome	611
	chr6:32,087,265–32,088,160	96.5 kb	Distal (>10kb) Multiome	473
	chr6:32,127,621–32,128,720	56.0 kb	Distal (>10kb) Multiome	683
	chr6:32,129,973–32,130,800	53.9 kb	Distal (>10kb) Multiome	717
	chr6:32,144,531–32,145,041	39.5 kb	Distal (>10kb) Multiome	44
	chr6:32,148,431–32,149,344	35.4 kb	Distal (>10kb) Multiome	145
	chr6:32,153,307–32,155,059	30.2 kb	Distal (>10kb) Multiome	908
	chr6:32,167,399–32,168,187	16.2 kb	Distal (>10kb) Multiome	411
	chr6:32,175,673–32,176,347	8.1 kb	Proximal (<10kb) Multiome	654
	chr6:32,177,078–32,178,952	6.2 kb	Proximal (<10kb) Multiome	820
	chr6:32,190,108–32,191,167	6.1 kb	Proximal (<10kb) Multiome	661
	chr6:32,195,084–32,196,878	11.5 kb	Distal (>10kb) Multiome	1063
	chr6:32,255,200–32,255,686	71.1 kb	Distal (>10kb) Multiome	364

Genome Browser

Genomic view of the AGER locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.