chr5 : 83,784,628 83,785,983
1,355 bp 81 TFs 1 linked gene
This 1.4 kb open chromatin element is linked to HAPLN1 and is bound by 81 transcription factors.
Linked Genes
1 gene
Gene Expression Dist. to TSS Distance Link type
HAPLN1 64.5 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr5:83,779,628 – 83,790,983
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
81 transcription factors
Source
Cell type
Arid3a 9 datasets
Motif DE_36h DE_36h-Arid3a_MA0151.1 6 bp overlap
Motif DE_36h DE_36h-Arid3a_MA0151.1 6 bp overlap
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap
CDX1 1 dataset
Motif DE_60h DE_60h-CDX1_MA0878.3 10 bp overlap
CDX2 1 dataset
Motif DE_60h DE_60h-CDX2_MA0465.3 8 bp overlap
CDX4 2 datasets
Motif DE_36h DE_36h-CDX4_MA1473.2 9 bp overlap
Motif DE_60h DE_60h-CDX4_MA1473.2 9 bp overlap
CRX 3 datasets
ChIP retina_Hu20 GSE137311.CRX.retina_Hu20 226 bp overlap
ChIP retina_Hu3 GSE137311.CRX.retina_Hu3 225 bp overlap
ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 402 bp overlap
CTCF 13 datasets
ChIP GM04648 GSE148179.CTCF.GM04648 51 bp overlap
ChIP GM23338 ENCFF832KWE 346 bp overlap
ChIP GM23338 ENCFF832KWE 147 bp overlap
ChIP HFFc6 ENCFF005CJI 215 bp overlap
ChIP RWPE1 ENCFF200GQF 358 bp overlap
ChIP RWPE1 ENCFF200GQF 159 bp overlap
ChIP SLK_Ctrl GSE138105.CTCF.SLK_Ctrl 181 bp overlap
ChIP SLK_RAD21-KD GSE138105.CTCF.SLK_RAD21-KD 110 bp overlap
ChIP chondrocyte ENCFF134ORZ 198 bp overlap
ChIP retina_AB1-RB GSE86981.CTCF.retina_AB1-RB 184 bp overlap
ChIP retina_Hu6 GSE137311.CTCF.retina_Hu6 275 bp overlap
ChIP testis ENCSR753RME.CTCF.testis 108 bp overlap
ChIP type B pancreatic cell ENCFF910FNQ 196 bp overlap
Crx 3 datasets
Motif DE_36h DE_36h-Crx_MA0467.3 6 bp overlap
Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap
Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap
DPRX 3 datasets
Motif DE_36h DE_36h-DPRX_MA1480.2 9 bp overlap
Motif DE_48h DE_48h-DPRX_MA1480.2 9 bp overlap
Motif DE_60h DE_60h-DPRX_MA1480.2 9 bp overlap
DUX4 6 datasets
Motif DE_36h DE_36h-DUX4_MA0468.1 11 bp overlap
Motif DE_36h DE_36h-DUX4_MA0468.1 11 bp overlap
Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap
Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap
Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap
Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap
Dux 6 datasets
Motif DE_36h DE_36h-Dux_MA0611.3 11 bp overlap
Motif DE_48h DE_48h-Dux_MA0611.3 11 bp overlap
Motif DE_48h DE_48h-Dux_MA0611.3 11 bp overlap
Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap
Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap
Motif DE_72h DE_72h-Dux_MA0611.3 11 bp overlap
EBF1 3 datasets
Motif DE_36h DE_36h-EBF1_MA0154.5 11 bp overlap
Motif DE_48h DE_48h-EBF1_MA0154.5 11 bp overlap
Motif DE_60h DE_60h-EBF1_MA0154.5 11 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 469 bp overlap
ETS1 1 dataset
ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 127 bp overlap
EZH2 1 dataset
ChIP neural progenitor cell ENCFF018MKA 494 bp overlap
Ebf4 3 datasets
Motif DE_36h DE_36h-Ebf4_MA2122.1 11 bp overlap
Motif DE_48h DE_48h-Ebf4_MA2122.1 11 bp overlap
Motif DE_60h DE_60h-Ebf4_MA2122.1 11 bp overlap
FEZF1 2 datasets
ChIP HEK293 ENCFF528YED 441 bp overlap
ChIP HEK293 ENCSR827NWO.FEZF1.HEK293 299 bp overlap
FOXA1 1 dataset
ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 443 bp overlap
FOXA2 3 datasets
ChIP DE DE-FOXA2-1 657 bp overlap
ChIP DE DE-FOXA2-2 641 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 395 bp overlap
FOXN3 3 datasets
Motif DE_36h DE_36h-FOXN3_MA1489.1 8 bp overlap
Motif DE_48h DE_48h-FOXN3_MA1489.1 8 bp overlap
Motif DE_60h DE_60h-FOXN3_MA1489.1 8 bp overlap
FOXP2 3 datasets
Motif DE_36h DE_36h-FOXP2_MA0593.2 9 bp overlap
Motif DE_48h DE_48h-FOXP2_MA0593.2 9 bp overlap
Motif DE_60h DE_60h-FOXP2_MA0593.2 9 bp overlap
GATA1 3 datasets
Motif DE_36h DE_36h-GATA1_MA0035.5 7 bp overlap
Motif DE_48h DE_48h-GATA1_MA0035.5 7 bp overlap
Motif DE_60h DE_60h-GATA1_MA0035.5 7 bp overlap
GATA2 4 datasets
Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap
Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap
Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap
ChIP hiPSC_SLC9ebs GSE107639.GATA2.hiPSC_SLC9ebs 206 bp overlap
GATA4 9 datasets
ChIP DE DE-GATA4-1 688 bp overlap
ChIP DE DE-GATA4-2 957 bp overlap
Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap
ChIP Hep-G2 GSE135714.GATA4.Hep-G2 491 bp overlap
ChIP foregut GSE117136.GATA4.foregut 484 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 800 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 789 bp overlap
GATA6 18 datasets
ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 102 bp overlap
ChIP DE DE-GATA6-1 663 bp overlap
ChIP DE DE-GATA6-2 1174 bp overlap
Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap
Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap
Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 970 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 889 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 798 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 1201 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 1003 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 1095 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 504 bp overlap
ChIP foregut GSE117136.GATA6.foregut 640 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 254 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 587 bp overlap
ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 674 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 790 bp overlap
GLIS1 3 datasets
Motif DE_36h DE_36h-GLIS1_MA0735.2 15 bp overlap
Motif DE_48h DE_48h-GLIS1_MA0735.2 15 bp overlap
Motif DE_60h DE_60h-GLIS1_MA0735.2 15 bp overlap
GLIS2 3 datasets
Motif DE_36h DE_36h-GLIS2_MA0736.1 14 bp overlap
Motif DE_48h DE_48h-GLIS2_MA0736.1 14 bp overlap
Motif DE_60h DE_60h-GLIS2_MA0736.1 14 bp overlap
GLIS3 3 datasets
Motif DE_36h DE_36h-GLIS3_MA0737.1 14 bp overlap
Motif DE_48h DE_48h-GLIS3_MA0737.1 14 bp overlap
Motif DE_60h DE_60h-GLIS3_MA0737.1 14 bp overlap
GSC 3 datasets
Motif DE_36h DE_36h-GSC_MA0648.2 6 bp overlap
Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap
Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap
GSC2 3 datasets
Motif DE_36h DE_36h-GSC2_MA0891.2 6 bp overlap
Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap
Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap
Gata3 3 datasets
Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap
Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap
Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap
HOXD9 2 datasets
Motif DE_36h DE_36h-HOXD9_MA0913.3 9 bp overlap
Motif DE_60h DE_60h-HOXD9_MA0913.3 9 bp overlap
Hnf1A 3 datasets
Motif DE_36h DE_36h-Hnf1A_MA1991.2 10 bp overlap
Motif DE_48h DE_48h-Hnf1A_MA1991.2 10 bp overlap
Motif DE_60h DE_60h-Hnf1A_MA1991.2 10 bp overlap
IRF4 2 datasets
Motif DE_48h DE_48h-IRF4_MA1419.2 14 bp overlap
Motif DE_60h DE_60h-IRF4_MA1419.2 14 bp overlap
IRF8 2 datasets
Motif DE_48h DE_48h-IRF8_MA0652.2 13 bp overlap
Motif DE_60h DE_60h-IRF8_MA0652.2 13 bp overlap
ISL2 3 datasets
Motif DE_36h DE_36h-ISL2_MA0914.2 6 bp overlap
Motif DE_48h DE_48h-ISL2_MA0914.2 6 bp overlap
Motif DE_60h DE_60h-ISL2_MA0914.2 6 bp overlap
Irf1 2 datasets
Motif DE_48h DE_48h-Irf1_MA0050.4 11 bp overlap
Motif DE_60h DE_60h-Irf1_MA0050.4 11 bp overlap
KDM1A 2 datasets
ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 289 bp overlap
ChIP pancreatic-progenitor_PP2-KDM1A-inh GSE104840.KDM1A.pancreatic-progenitor_PP2-KDM1A-inh 353 bp overlap
Lef1 3 datasets
Motif DE_36h DE_36h-Lef1_MA0768.3 8 bp overlap
Motif DE_48h DE_48h-Lef1_MA0768.3 8 bp overlap
Motif DE_60h DE_60h-Lef1_MA0768.3 8 bp overlap
MEIS1 3 datasets
Motif DE_48h DE_48h-MEIS1_MA1639.2 9 bp overlap
Motif DE_60h DE_60h-MEIS1_MA1639.2 9 bp overlap
Motif DE_72h DE_72h-MEIS1_MA1639.2 9 bp overlap
MEIS2 3 datasets
Motif DE_48h DE_48h-MEIS2_MA1640.2 9 bp overlap
Motif DE_60h DE_60h-MEIS2_MA1640.2 9 bp overlap
Motif DE_72h DE_72h-MEIS2_MA1640.2 9 bp overlap
Mecom 3 datasets
Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap
Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap
Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap
NEUROD1 5 datasets
ChIP D283-Med GSE92582.NEUROD1.D283-Med 718 bp overlap
ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 488 bp overlap
ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 219 bp overlap
ChIP D341-Med_shNEUROD1-1154 GSE92582.NEUROD1.D341-Med_shNEUROD1-1154 309 bp overlap
ChIP D341-Med_shNEUROD1-1579 GSE92582.NEUROD1.D341-Med_shNEUROD1-1579 282 bp overlap
ONECUT1 2 datasets
ChIP H9 ERP004206.ONECUT1.H9 190 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.ONECUT1.pancreatic-progenitor_PP1 479 bp overlap
OTX1 3 datasets
Motif DE_36h DE_36h-OTX1_MA0711.2 6 bp overlap
Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap
Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap
OTX2 1 dataset
ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 385 bp overlap
PBX1 3 datasets
Motif DE_48h DE_48h-PBX1_MA0070.2 9 bp overlap
Motif DE_60h DE_60h-PBX1_MA0070.2 9 bp overlap
Motif DE_72h DE_72h-PBX1_MA0070.2 9 bp overlap
PDX1 4 datasets
ChIP hESC GSE58685.PDX1.hESC 173 bp overlap
ChIP hiPSC GSE125768.PDX1.hiPSC 444 bp overlap
ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 440 bp overlap
ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 549 bp overlap
PHOX2A 3 datasets
Motif DE_36h DE_36h-PHOX2A_MA0713.1 11 bp overlap
Motif DE_48h DE_48h-PHOX2A_MA0713.1 11 bp overlap
Motif DE_60h DE_60h-PHOX2A_MA0713.1 11 bp overlap
PITX1 3 datasets
Motif DE_36h DE_36h-PITX1_MA0682.3 6 bp overlap
Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap
Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap
PITX2 3 datasets
Motif DE_36h DE_36h-PITX2_MA1547.2 8 bp overlap
Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap
Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap
PITX3 3 datasets
Motif DE_36h DE_36h-PITX3_MA0714.2 6 bp overlap
Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap
Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap
Prdm15 3 datasets
Motif DE_36h DE_36h-Prdm15_MA1616.2 11 bp overlap
Motif DE_48h DE_48h-Prdm15_MA1616.2 11 bp overlap
Motif DE_60h DE_60h-Prdm15_MA1616.2 11 bp overlap
RAD21 3 datasets
ChIP HAP1 GSE152721.RAD21.HAP1 251 bp overlap
ChIP HAP1_clone25 GSE152721.RAD21.HAP1_clone25 293 bp overlap
ChIP HepG2 ENCFF360ZSW 217 bp overlap
RHOXF1 3 datasets
Motif DE_36h DE_36h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap
RXRA::VDR 6 datasets
Motif DE_36h DE_36h-RXRAVDR_MA0074.1 15 bp overlap
Motif DE_36h DE_36h-RXRAVDR_MA0074.1 15 bp overlap
Motif DE_48h DE_48h-RXRAVDR_MA0074.1 15 bp overlap
Motif DE_48h DE_48h-RXRAVDR_MA0074.1 15 bp overlap
Motif DE_60h DE_60h-RXRAVDR_MA0074.1 15 bp overlap
Motif DE_60h DE_60h-RXRAVDR_MA0074.1 15 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 599 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 708 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 444 bp overlap
SMAD2_3 3 datasets
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 560 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 612 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 478 bp overlap
SMARCC1 1 dataset
ChIP DE_D1 S15-DE-d1-BAF155-exp1 449 bp overlap
SMARCE1 1 dataset
ChIP HMLE-Twist-ER_125nM_4OHT GSE96933.SMARCE1.HMLE-Twist-ER_125nM_4OHT 187 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 424 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 995 bp overlap
STAT1::STAT2 2 datasets
Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_60h DE_60h-STAT1STAT2_MA0517.2 13 bp overlap
Stat2 5 datasets
Motif DE_36h DE_36h-Stat2_MA1623.2 10 bp overlap
Motif DE_48h DE_48h-Stat2_MA1623.2 10 bp overlap
Motif DE_48h DE_48h-Stat2_MA1623.2 10 bp overlap
Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap
Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap
T 1 dataset
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 295 bp overlap
TBP 3 datasets
Motif DE_36h DE_36h-TBP_MA0108.3 7 bp overlap
Motif DE_48h DE_48h-TBP_MA0108.3 7 bp overlap
Motif DE_60h DE_60h-TBP_MA0108.3 7 bp overlap
TCF7L1 3 datasets
Motif DE_36h DE_36h-TCF7L1_MA1421.1 12 bp overlap
Motif DE_48h DE_48h-TCF7L1_MA1421.1 12 bp overlap
Motif DE_60h DE_60h-TCF7L1_MA1421.1 12 bp overlap
TERF1 1 dataset
ChIP LCL GSE55053.TERF1.LCL 196 bp overlap
TRPS1 3 datasets
Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap
Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap
Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap
ZFP69B 1 dataset
ChIP HEK293T GSE78099.ZFP69B.HEK293T 425 bp overlap
ZNF205 1 dataset
ChIP HEK293T GSE78099.ZNF205.HEK293T 295 bp overlap
ZNF214 3 datasets
Motif DE_36h DE_36h-ZNF214_MA1975.2 13 bp overlap
Motif DE_48h DE_48h-ZNF214_MA1975.2 13 bp overlap
Motif DE_60h DE_60h-ZNF214_MA1975.2 13 bp overlap
ZNF274 2 datasets
Motif DE_48h DE_48h-ZNF274_MA1592.2 12 bp overlap
Motif DE_60h DE_60h-ZNF274_MA1592.2 12 bp overlap
ZNF418 2 datasets
Motif DE_48h DE_48h-ZNF418_MA1980.1 15 bp overlap
Motif DE_60h DE_60h-ZNF418_MA1980.1 15 bp overlap
ZNF479 1 dataset
ChIP HEK293T GSE78099.ZNF479.HEK293T 178 bp overlap
ZNF558 3 datasets
Motif DE_36h DE_36h-ZNF558_MA2335.1 29 bp overlap
Motif DE_48h DE_48h-ZNF558_MA2335.1 29 bp overlap
Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap
ZNF667 2 datasets
Motif DE_48h DE_48h-ZNF667_MA1984.2 11 bp overlap
Motif DE_60h DE_60h-ZNF667_MA1984.2 11 bp overlap
ZNF680 3 datasets
Motif DE_48h DE_48h-ZNF680_MA1729.2 11 bp overlap
Motif DE_60h DE_60h-ZNF680_MA1729.2 11 bp overlap
Motif DE_72h DE_72h-ZNF680_MA1729.2 11 bp overlap
ZNF75A 3 datasets
Motif DE_36h DE_36h-ZNF75A_MA2097.1 12 bp overlap
Motif DE_48h DE_48h-ZNF75A_MA2097.1 12 bp overlap
Motif DE_60h DE_60h-ZNF75A_MA2097.1 12 bp overlap
ZNF766 3 datasets
Motif DE_36h DE_36h-ZNF766_MA2098.1 9 bp overlap
Motif DE_48h DE_48h-ZNF766_MA2098.1 9 bp overlap
Motif DE_60h DE_60h-ZNF766_MA2098.1 9 bp overlap
Znf423 3 datasets
Motif DE_36h DE_36h-Znf423_MA0116.1 15 bp overlap
Motif DE_48h DE_48h-Znf423_MA0116.1 15 bp overlap
Motif DE_60h DE_60h-Znf423_MA0116.1 15 bp overlap