Predicted to enable hyaluronic acid binding activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Predicted to be involved in central nervous system development and skeletal system development. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for HAPLN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAPLN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAPLN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:83,470,946–83,472,020 | 249.4 kb | Distal (>10kb) Multiome | 379 | |
| chr5:83,472,395–83,475,303 | 246.2 kb | Distal (>10kb) Multiome | 827 | |
| chr5:83,493,487–83,495,007 | 226.2 kb | Distal (>10kb) Multiome | 320 | |
| chr5:83,712,096–83,712,278 | 8.6 kb | Proximal (<10kb) | 124 | |
| chr5:83,714,660–83,715,756 | 5.8 kb | Proximal (<10kb) Multiome | 275 | |
| chr5:83,718,259–83,718,713 | 2.1 kb | Proximal (<10kb) | 192 | |
| chr5:83,720,773–83,722,967 | 1.5 kb | Proximal (<10kb) Multiome | 698 | |
| chr5:83,723,198–83,723,544 | 2.3 kb | Proximal (<10kb) | 71 | |
| chr5:83,784,628–83,785,983 | 64.5 kb | Distal (>10kb) Multiome | 81 | |
| chr5:83,925,635–83,927,060 | 205.3 kb | Distal (>10kb) Multiome | 188 | |
| chr5:84,480,888–84,481,719 | 760.4 kb | Distal (>10kb) Multiome HiCAR | 161 |
Genomic view of the HAPLN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.