chr1:93,474,058–93,474,810

chr1 : 93,474,058 – 93,474,810

752 bp 63 TFs 7 linked genes

This 752 bp open chromatin element is linked to 7 target genes and is bound by 63 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
FNBP1L		26.3 kb	Distal	Multiome
BCAR3-AS1		117.6 kb	Distal	Multiome
DR1		128.4 kb	Distal	Multiome
CCDC18-AS1		128.5 kb	Distal	Multiome
BCAR3		207.5 kb	Distal	Multiome
CCDC18		293.7 kb	Distal	Multiome
TMED5		294.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

63 transcription factors

ARNT::HIF1A 3 datasets

Motif DE_36h DE_36h-ARNTHIF1A_MA0259.2 5 bp overlap

Motif DE_48h DE_48h-ARNTHIF1A_MA0259.2 5 bp overlap

Motif DE_60h DE_60h-ARNTHIF1A_MA0259.2 5 bp overlap

CEBPA 4 datasets

Motif DE_36h DE_36h-CEBPA_MA0102.5 10 bp overlap

Motif DE_48h DE_48h-CEBPA_MA0102.5 10 bp overlap

Motif DE_60h DE_60h-CEBPA_MA0102.5 10 bp overlap

Motif DE_72h DE_72h-CEBPA_MA0102.5 10 bp overlap

CEBPD 5 datasets

Motif DE_36h DE_36h-CEBPD_MA0836.3 8 bp overlap

Motif DE_48h DE_48h-CEBPD_MA0836.3 8 bp overlap

Motif DE_60h DE_60h-CEBPD_MA0836.3 8 bp overlap

Motif DE_72h DE_72h-CEBPD_MA0836.3 8 bp overlap

ChIP K-562 ENCSR000BVY.CEBPD.K-562 103 bp overlap

CREB1 1 dataset

Motif DE_48h DE_48h-CREB1_MA0018.5 8 bp overlap

ELK1::SREBF2 1 dataset

Motif DE_48h DE_48h-ELK1SREBF2_MA1933.2 15 bp overlap

EOMES 4 datasets

Motif DE_36h DE_36h-EOMES_MA0800.2 9 bp overlap

Motif DE_48h DE_48h-EOMES_MA0800.2 9 bp overlap

Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 355 bp overlap

ESRRG 1 dataset

ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 455 bp overlap

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 509 bp overlap

FOXA2 3 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 240 bp overlap

ChIP DE DE-FOXA2-1 319 bp overlap

ChIP DE DE-FOXA2-2 335 bp overlap

GATA1 3 datasets

ChIP K-562 GSE107726.GATA1.K-562 314 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 145 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 293 bp overlap

GATA2 16 datasets

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

ChIP ESF GSE108408.GATA2.ESF 231 bp overlap

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 191 bp overlap

ChIP WA09 GSE105081.GATA2.WA09 141 bp overlap

ChIP primary-endometrial-stromal-cell_IVD_P1 GSE145673.GATA2.primary-endometrial-stromal-cell_IVD_P1 270 bp overlap

GATA3 1 dataset

ChIP SK-N-SH ENCFF040SSB 365 bp overlap

GATA4 26 datasets

ChIP DE DE-GATA4-1 683 bp overlap

ChIP DE DE-GATA4-2 706 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP G296S GSE85628.GATA4.G296S 434 bp overlap

ChIP G296S_2 GSE85628.GATA4.G296S_2 434 bp overlap

ChIP G296S_4 GSE85628.GATA4.G296S_4 274 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 383 bp overlap

ChIP YCC-3 GSE51705.GATA4.YCC-3 287 bp overlap

ChIP cardiomyocyte GSE85628.GATA4.cardiomyocyte 270 bp overlap

ChIP cardiomyocyte_1 GSE85628.GATA4.cardiomyocyte_1 281 bp overlap

ChIP cardiomyocyte_5 GSE85628.GATA4.cardiomyocyte_5 302 bp overlap

ChIP cardiomyocyte_7 GSE85628.GATA4.cardiomyocyte_7 189 bp overlap

ChIP foregut GSE117136.GATA4.foregut 286 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 431 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 254 bp overlap

GATA5 4 datasets

Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 26 datasets

ChIP AGS GSE51705.GATA6.AGS 271 bp overlap

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 198 bp overlap

ChIP DE DE-GATA6-1 615 bp overlap

ChIP DE DE-GATA6-2 752 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 720 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 691 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 619 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 752 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 664 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 634 bp overlap

ChIP YCC-3 GSE51705.GATA6.YCC-3 301 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 585 bp overlap

ChIP foregut GSE117136.GATA6.foregut 375 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 423 bp overlap

Gata3 12 datasets

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HIF1A 3 datasets

Motif DE_36h DE_36h-HIF1A_MA1106.2 6 bp overlap

Motif DE_48h DE_48h-HIF1A_MA1106.2 6 bp overlap

Motif DE_60h DE_60h-HIF1A_MA1106.2 6 bp overlap

IRF2 3 datasets

Motif DE_36h DE_36h-IRF2_MA0051.2 16 bp overlap

Motif DE_48h DE_48h-IRF2_MA0051.2 16 bp overlap

Motif DE_60h DE_60h-IRF2_MA0051.2 16 bp overlap

IRF3 3 datasets

Motif DE_36h DE_36h-IRF3_MA1418.2 17 bp overlap

Motif DE_48h DE_48h-IRF3_MA1418.2 17 bp overlap

Motif DE_60h DE_60h-IRF3_MA1418.2 17 bp overlap

MEF2C 3 datasets

Motif DE_36h DE_36h-MEF2C_MA0497.2 11 bp overlap

Motif DE_48h DE_48h-MEF2C_MA0497.2 11 bp overlap

Motif DE_60h DE_60h-MEF2C_MA0497.2 11 bp overlap

Motif DE_36h DE_36h-MGA_MA0801.1 8 bp overlap

Motif DE_48h DE_48h-MGA_MA0801.1 8 bp overlap

Motif DE_60h DE_60h-MGA_MA0801.1 8 bp overlap

Mecom 4 datasets

Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap

Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap

Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap

Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap

NFATC3 3 datasets

Motif DE_36h DE_36h-NFATC3_MA0625.3 6 bp overlap

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

NFATC4 3 datasets

Motif DE_36h DE_36h-NFATC4_MA1525.3 9 bp overlap

Motif DE_48h DE_48h-NFATC4_MA1525.3 9 bp overlap

Motif DE_60h DE_60h-NFATC4_MA1525.3 9 bp overlap

NKX2-5 2 datasets

ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 333 bp overlap

ChIP hESC_sc-14033 GSE89457.NKX2-5.hESC_sc-14033 331 bp overlap

Nfatc1 3 datasets

Motif DE_36h DE_36h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Nr2e1 1 dataset

Motif DE_48h DE_48h-Nr2e1_MA0676.1 9 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 268 bp overlap

PSIP1 1 dataset

ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 114 bp overlap

Pparg::Rxra 3 datasets

Motif DE_36h DE_36h-PpargRxra_MA0065.3 13 bp overlap

Motif DE_48h DE_48h-PpargRxra_MA0065.3 13 bp overlap

Motif DE_60h DE_60h-PpargRxra_MA0065.3 13 bp overlap

SETDB1 2 datasets

ChIP HEK293 ENCSR348AGV.SETDB1.HEK293 93 bp overlap

ChIP U2OS ENCSR000EYD.SETDB1.U2OS 93 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 555 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 394 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 261 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 561 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 548 bp overlap

SMAD4 1 dataset

ChIP Caco-2 GSE112946.SMAD4.Caco-2 208 bp overlap

SMARCA4 4 datasets

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-K785R 334 bp overlap

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-K785R 61 bp overlap

ChIP BIN-67_lentivirus-SMARCA4-T910M GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-T910M 351 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 174 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 237 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 563 bp overlap

SOX9 3 datasets

Motif DE_36h DE_36h-SOX9_MA0077.2 8 bp overlap

Motif DE_48h DE_48h-SOX9_MA0077.2 8 bp overlap

Motif DE_60h DE_60h-SOX9_MA0077.2 8 bp overlap

SPDEF 1 dataset

ChIP A-549 GSE86957.SPDEF.A-549 327 bp overlap

Motif DE_48h DE_48h-SPIB_MA0081.3 13 bp overlap

ChIP BIN-67_lentivirus-SMARCA4-T910M GSE117734.SS18.BIN-67_lentivirus-SMARCA4-T910M 276 bp overlap

STAT1::STAT2 3 datasets

Motif DE_36h DE_36h-STAT1STAT2_MA0517.2 13 bp overlap

Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap

Motif DE_60h DE_60h-STAT1STAT2_MA0517.2 13 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

TBR1 3 datasets

Motif DE_36h DE_36h-TBR1_MA0802.2 9 bp overlap

Motif DE_48h DE_48h-TBR1_MA0802.2 9 bp overlap

Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap

TBX1 3 datasets

Motif DE_36h DE_36h-TBX1_MA0805.1 8 bp overlap

Motif DE_48h DE_48h-TBX1_MA0805.1 8 bp overlap

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

TBX15 3 datasets

Motif DE_36h DE_36h-TBX15_MA0803.1 8 bp overlap

Motif DE_48h DE_48h-TBX15_MA0803.1 8 bp overlap

Motif DE_60h DE_60h-TBX15_MA0803.1 8 bp overlap

TBX4 3 datasets

Motif DE_36h DE_36h-TBX4_MA0806.1 8 bp overlap

Motif DE_48h DE_48h-TBX4_MA0806.1 8 bp overlap

Motif DE_60h DE_60h-TBX4_MA0806.1 8 bp overlap

TBX5 6 datasets

ChIP G296S GSE85628.TBX5.G296S 542 bp overlap

ChIP G296S_2 GSE85628.TBX5.G296S_2 542 bp overlap

ChIP G296S_4 GSE85628.TBX5.G296S_4 356 bp overlap

ChIP cardiomyocyte_5 GSE85628.TBX5.cardiomyocyte_5 461 bp overlap

ChIP cardiomyocyte_7 GSE85628.TBX5.cardiomyocyte_7 354 bp overlap

ChIP hiPSC GSE81585.TBX5.hiPSC 431 bp overlap

TCF7L2 4 datasets

Motif DE_36h DE_36h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_48h DE_48h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_60h DE_60h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_72h DE_72h-TCF7L2_MA0523.2 9 bp overlap

TFAP2A 1 dataset

ChIP WA09 GSE105081.TFAP2A.WA09 149 bp overlap

TRPS1 12 datasets

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ZBTB26 4 datasets

Motif DE_36h DE_36h-ZBTB26_MA1579.2 8 bp overlap

Motif DE_48h DE_48h-ZBTB26_MA1579.2 8 bp overlap

Motif DE_60h DE_60h-ZBTB26_MA1579.2 8 bp overlap

Motif DE_72h DE_72h-ZBTB26_MA1579.2 8 bp overlap

ZBTB33 1 dataset

ChIP K-562 ENCSR876GXA.ZBTB33.K-562 253 bp overlap

ZKSCAN5 1 dataset

Motif DE_48h DE_48h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF257 4 datasets

Motif DE_36h DE_36h-ZNF257_MA1710.2 10 bp overlap

Motif DE_48h DE_48h-ZNF257_MA1710.2 10 bp overlap

Motif DE_60h DE_60h-ZNF257_MA1710.2 10 bp overlap

Motif DE_72h DE_72h-ZNF257_MA1710.2 10 bp overlap

ZNF416 4 datasets

Motif DE_36h DE_36h-ZNF416_MA1979.2 10 bp overlap

Motif DE_48h DE_48h-ZNF416_MA1979.2 10 bp overlap

Motif DE_60h DE_60h-ZNF416_MA1979.2 10 bp overlap

Motif DE_72h DE_72h-ZNF416_MA1979.2 10 bp overlap

ZNF528 3 datasets

Motif DE_36h DE_36h-ZNF528_MA1597.1 17 bp overlap

Motif DE_48h DE_48h-ZNF528_MA1597.1 17 bp overlap

Motif DE_60h DE_60h-ZNF528_MA1597.1 17 bp overlap

ZNF530 4 datasets

Motif DE_36h DE_36h-ZNF530_MA1981.2 14 bp overlap

Motif DE_48h DE_48h-ZNF530_MA1981.2 14 bp overlap

Motif DE_60h DE_60h-ZNF530_MA1981.2 14 bp overlap

Motif DE_72h DE_72h-ZNF530_MA1981.2 14 bp overlap

ZNF582 4 datasets

Motif DE_36h DE_36h-ZNF582_MA1983.2 19 bp overlap

Motif DE_48h DE_48h-ZNF582_MA1983.2 19 bp overlap

Motif DE_60h DE_60h-ZNF582_MA1983.2 19 bp overlap

Motif DE_72h DE_72h-ZNF582_MA1983.2 19 bp overlap

ZNF677 4 datasets

Motif DE_36h DE_36h-ZNF677_MA2101.1 12 bp overlap

Motif DE_48h DE_48h-ZNF677_MA2101.1 12 bp overlap

Motif DE_60h DE_60h-ZNF677_MA2101.1 12 bp overlap

Motif DE_72h DE_72h-ZNF677_MA2101.1 12 bp overlap

ZNF692 4 datasets

Motif DE_36h DE_36h-ZNF692_MA1986.2 8 bp overlap

Motif DE_48h DE_48h-ZNF692_MA1986.2 8 bp overlap

Motif DE_60h DE_60h-ZNF692_MA1986.2 8 bp overlap

Motif DE_72h DE_72h-ZNF692_MA1986.2 8 bp overlap

ZNF768 4 datasets

Motif DE_36h DE_36h-ZNF768_MA1731.2 9 bp overlap

Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap

Motif DE_60h DE_60h-ZNF768_MA1731.2 9 bp overlap

Motif DE_72h DE_72h-ZNF768_MA1731.2 9 bp overlap

ZNF790 1 dataset

ChIP HepG2 ENCFF743NFR 55 bp overlap