The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FNBP1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNBP1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNBP1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:93,179,586–93,181,175 | 267.6 kb | Distal (>10kb) Multiome | 1019 | |
| chr1:93,345,396–93,346,457 | 102.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:93,442,314–93,442,599 | 5.5 kb | Proximal (<10kb) | 114 | |
| chr1:93,447,560–93,449,029 | 23 bp | At TSS Multiome | 726 | |
| chr1:93,449,100–93,449,472 | 983 bp | At TSS | 373 | |
| chr1:93,474,058–93,474,810 | 26.3 kb | Distal (>10kb) Multiome | 63 | |
| chr1:93,484,155–93,485,250 | 36.7 kb | Distal (>10kb) Multiome | 146 | |
| chr1:93,622,085–93,622,775 | 174.2 kb | Distal (>10kb) Multiome | 282 | |
| chr1:93,678,776–93,679,511 | 231.1 kb | Distal (>10kb) Multiome | 96 | |
| chr1:93,680,733–93,682,277 | 233.8 kb | Distal (>10kb) Multiome | 717 | |
| chr1:93,814,055–93,816,005 | 367.2 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr1:93,820,560–93,821,453 | 373.0 kb | Distal (>10kb) Multiome HiCAR | 160 | |
| chr1:93,845,985–93,846,892 | 398.1 kb | Distal (>10kb) Multiome HiCAR | 732 | |
| chr1:93,846,995–93,848,315 | 399.4 kb | Distal (>10kb) Multiome HiCAR | 954 | |
| chr1:93,878,726–93,879,400 | 431.1 kb | Distal (>10kb) Multiome HiCAR | 851 |
Genomic view of the FNBP1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.