Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:92,960,419–92,962,220 | 219.2 kb | Distal (>10kb) Multiome | 873 | |
| chr1:93,029,424–93,029,880 | 151.1 kb | Distal (>10kb) Multiome | 92 | |
| chr1:93,078,561–93,080,172 | 101.5 kb | Distal (>10kb) Multiome | 1219 | |
| chr1:93,179,586–93,181,175 | 201 bp | At TSS Multiome | 1019 | |
| chr1:93,345,396–93,346,457 | 165.1 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:93,447,560–93,449,029 | 267.4 kb | Distal (>10kb) Multiome | 726 | |
| chr1:93,474,058–93,474,810 | 293.7 kb | Distal (>10kb) Multiome | 63 | |
| chr1:93,845,985–93,846,892 | 665.5 kb | Distal (>10kb) Multiome HiCAR | 732 | |
| chr1:93,846,995–93,848,315 | 666.8 kb | Distal (>10kb) Multiome HiCAR | 954 |
Genomic view of the CCDC18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.