chr4 : 78,244,366 – 78,245,413
1,047 bp 80 TFs 1 linked gene
This 1.0 kb open chromatin element is linked to FRAS1 and is bound by 80 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
FRAS1 187.6 kb Distal Multiome+HiCAR
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr4:78,239,366 – 78,250,413
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
80 transcription factors
Source
Cell type
AR 1 dataset
ChIP MDA-MB-453_FOXA1 ERP003503.AR.MDA-MB-453_FOXA1 140 bp overlap
BHLHE22 7 datasets
Motif DE_36h DE_36h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_72h DE_72h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_72h DE_72h-BHLHE22_MA1635.2 6 bp overlap
BRCA1 1 dataset
ChIP K-562 ENCSR223MLH.BRCA1.K-562 320 bp overlap
BRD4 1 dataset
ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 263 bp overlap
Bhlha15 4 datasets
Motif DE_36h DE_36h-Bhlha15_MA1472.3 8 bp overlap
Motif DE_48h DE_48h-Bhlha15_MA1472.3 8 bp overlap
Motif DE_60h DE_60h-Bhlha15_MA1472.3 8 bp overlap
Motif DE_72h DE_72h-Bhlha15_MA1472.3 8 bp overlap
CEBPD 4 datasets
Motif DE_36h DE_36h-CEBPD_MA0836.3 8 bp overlap
Motif DE_48h DE_48h-CEBPD_MA0836.3 8 bp overlap
Motif DE_60h DE_60h-CEBPD_MA0836.3 8 bp overlap
Motif DE_72h DE_72h-CEBPD_MA0836.3 8 bp overlap
CTCF 1 dataset
Motif DE_60h DE_60h-CTCF_MA1930.2 33 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 811 bp overlap
ERG 1 dataset
ChIP AMLPZ12 GSE23730.ERG.AMLPZ12 203 bp overlap
ESR1 3 datasets
Motif DE_48h DE_48h-ESR1_MA0112.4 15 bp overlap
Motif DE_60h DE_60h-ESR1_MA0112.4 15 bp overlap
Motif DE_72h DE_72h-ESR1_MA0112.4 15 bp overlap
FIGLA 4 datasets
Motif DE_36h DE_36h-FIGLA_MA0820.2 6 bp overlap
Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap
Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap
Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 935 bp overlap
ChIP DE DE-FOXA2-2 934 bp overlap
GATA2 7 datasets
Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap
Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap
Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap
Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap
ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 237 bp overlap
ChIP TF1 GSE73207.GATA2.TF1 272 bp overlap
ChIP hiPSC_SLC6ebs GSE107639.GATA2.hiPSC_SLC6ebs 186 bp overlap
GATA3 2 datasets
ChIP MCF-7_E2 GSE40129.GATA3.MCF-7_E2 121 bp overlap
ChIP SK-N-SH ENCFF040SSB 365 bp overlap
GATA4 9 datasets
ChIP DE DE-GATA4-1 923 bp overlap
ChIP DE DE-GATA4-2 998 bp overlap
Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap
Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap
ChIP Hep-G2 GSE135714.GATA4.Hep-G2 197 bp overlap
ChIP foregut GSE117136.GATA4.foregut 580 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 447 bp overlap
GATA6 16 datasets
ChIP DE DE-GATA6-1 970 bp overlap
ChIP DE DE-GATA6-2 994 bp overlap
Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap
Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap
Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap
Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 701 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 826 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 669 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 942 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 894 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 775 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 879 bp overlap
ChIP foregut GSE117136.GATA6.foregut 501 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 286 bp overlap
ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 264 bp overlap
GLIS1 1 dataset
ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 665 bp overlap
Gata3 4 datasets
Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap
Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap
Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap
Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap
HNF4A 1 dataset
ChIP Caco-2_DIFF GSE23436.HNF4A.Caco-2_DIFF 321 bp overlap
Hand1::Tcf3 4 datasets
Motif DE_36h DE_36h-Hand1Tcf3_MA0092.2 9 bp overlap
Motif DE_48h DE_48h-Hand1Tcf3_MA0092.2 9 bp overlap
Motif DE_60h DE_60h-Hand1Tcf3_MA0092.2 9 bp overlap
Motif DE_72h DE_72h-Hand1Tcf3_MA0092.2 9 bp overlap
IRF1 1 dataset
ChIP HAEC_TNFa_4h GSE89970.IRF1.HAEC_TNFa_4h 131 bp overlap
JUN 3 datasets
ChIP DE_D1 S40-DE-d1-JUN-exp2 415 bp overlap
ChIP DE_D2 S02-DE-d2-JUN-exp1 376 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 437 bp overlap
MAFB 1 dataset
ChIP islet ERP004003.MAFB.islet 149 bp overlap
MEIS1 1 dataset
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
MYF5 4 datasets
Motif DE_36h DE_36h-MYF5_MA1641.2 8 bp overlap
Motif DE_48h DE_48h-MYF5_MA1641.2 8 bp overlap
Motif DE_60h DE_60h-MYF5_MA1641.2 8 bp overlap
Motif DE_72h DE_72h-MYF5_MA1641.2 8 bp overlap
MYOD1 4 datasets
Motif DE_36h DE_36h-MYOD1_MA0499.3 9 bp overlap
Motif DE_48h DE_48h-MYOD1_MA0499.3 9 bp overlap
Motif DE_60h DE_60h-MYOD1_MA0499.3 9 bp overlap
Motif DE_72h DE_72h-MYOD1_MA0499.3 9 bp overlap
Mecom 4 datasets
Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap
Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap
Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap
Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap
NEUROD1 4 datasets
Motif DE_36h DE_36h-NEUROD1_MA1109.2 8 bp overlap
Motif DE_48h DE_48h-NEUROD1_MA1109.2 8 bp overlap
Motif DE_60h DE_60h-NEUROD1_MA1109.2 8 bp overlap
Motif DE_72h DE_72h-NEUROD1_MA1109.2 8 bp overlap
NHLH1 3 datasets
Motif DE_48h DE_48h-NHLH1_MA0048.3 9 bp overlap
Motif DE_60h DE_60h-NHLH1_MA0048.3 9 bp overlap
Motif DE_72h DE_72h-NHLH1_MA0048.3 9 bp overlap
NKX2-1 1 dataset
ChIP NCI-H1819 GSE39998.NKX2-1.NCI-H1819 302 bp overlap
NR1I3 1 dataset
Motif DE_60h DE_60h-NR1I3_MA1534.2 8 bp overlap
Neurod2 11 datasets
Motif DE_36h DE_36h-Neurod2_MA0668.3 8 bp overlap
Motif DE_36h DE_36h-Neurod2_MA1993.2 6 bp overlap
Motif DE_48h DE_48h-Neurod2_MA0668.3 8 bp overlap
Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap
Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap
Motif DE_60h DE_60h-Neurod2_MA0668.3 8 bp overlap
Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap
Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap
Motif DE_72h DE_72h-Neurod2_MA0668.3 8 bp overlap
Motif DE_72h DE_72h-Neurod2_MA1993.2 6 bp overlap
Motif DE_72h DE_72h-Neurod2_MA1993.2 6 bp overlap
Nr1h3::Rxra 1 dataset
Motif DE_60h DE_60h-Nr1h3Rxra_MA0494.2 16 bp overlap
Olig2 7 datasets
Motif DE_36h DE_36h-Olig2_MA1997.2 6 bp overlap
Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap
Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap
Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap
Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap
Motif DE_72h DE_72h-Olig2_MA1997.2 6 bp overlap
Motif DE_72h DE_72h-Olig2_MA1997.2 6 bp overlap
PRDM1 1 dataset
ChIP HEK293 ENCFF302TBP 213 bp overlap
PRDM6 4 datasets
ChIP HEK293 ENCFF283AJL 203 bp overlap
ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 285 bp overlap
ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 308 bp overlap
ChIP HEK293 GSE76494.PRDM6.HEK293 230 bp overlap
Prdm4 1 dataset
Motif DE_60h DE_60h-Prdm4_MA1647.3 11 bp overlap
Ptf1A 4 datasets
Motif DE_36h DE_36h-Ptf1A_MA1619.2 8 bp overlap
Motif DE_48h DE_48h-Ptf1A_MA1619.2 8 bp overlap
Motif DE_60h DE_60h-Ptf1A_MA1619.2 8 bp overlap
Motif DE_72h DE_72h-Ptf1A_MA1619.2 8 bp overlap
RBPJ 4 datasets
Motif DE_36h DE_36h-RBPJ_MA1116.2 6 bp overlap
Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap
Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap
Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap
Rarg 1 dataset
Motif DE_60h DE_60h-Rarg_MA0860.1 17 bp overlap
SIX2 3 datasets
ChIP HEK GSE73865.SIX2.HEK 714 bp overlap
ChIP kidney_fetal_16w GSE75948.SIX2.kidney_fetal_16w 602 bp overlap
ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 557 bp overlap
SMAD2 5 datasets
Motif DE_36h DE_36h-SMAD2_MA1964.2 6 bp overlap
Motif DE_48h DE_48h-SMAD2_MA1964.2 6 bp overlap
Motif DE_60h DE_60h-SMAD2_MA1964.2 6 bp overlap
Motif DE_72h DE_72h-SMAD2_MA1964.2 6 bp overlap
ChIP endoderm GSE29422.SMAD2.endoderm 178 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 933 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 511 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 417 bp overlap
SMAD2_3 4 datasets
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 432 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 279 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 943 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 819 bp overlap
SMARCA4 1 dataset
ChIP hiPSC GSE124903.SMARCA4.hiPSC 324 bp overlap
SMARCC1 2 datasets
ChIP DE_D1 S15-DE-d1-BAF155-exp1 395 bp overlap
ChIP hiPSC GSE124903.SMARCC1.hiPSC 209 bp overlap
SOX15 1 dataset
Motif DE_60h DE_60h-SOX15_MA1152.2 7 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 759 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 853 bp overlap
SREBF1 1 dataset
Motif DE_60h DE_60h-SREBF1_MA0595.1 10 bp overlap
SREBF2 1 dataset
Motif DE_60h DE_60h-SREBF2_MA0596.1 10 bp overlap
STAT1 5 datasets
ChIP CD14 GSE43036.STAT1.CD14 114 bp overlap
Motif DE_36h DE_36h-STAT1_MA0137.4 9 bp overlap
Motif DE_48h DE_48h-STAT1_MA0137.4 9 bp overlap
Motif DE_60h DE_60h-STAT1_MA0137.4 9 bp overlap
Motif DE_72h DE_72h-STAT1_MA0137.4 9 bp overlap
STAT3 7 datasets
Motif DE_36h DE_36h-STAT3_MA0144.3 9 bp overlap
Motif DE_48h DE_48h-STAT3_MA0144.3 9 bp overlap
Motif DE_60h DE_60h-STAT3_MA0144.3 9 bp overlap
Motif DE_72h DE_72h-STAT3_MA0144.3 9 bp overlap
ChIP MCF-7_jc5836 GSE126004.STAT3.MCF-7_jc5836 377 bp overlap
ChIP MCF-7_jc5838 GSE126004.STAT3.MCF-7_jc5838 337 bp overlap
ChIP MCF-7_jc5840 GSE126004.STAT3.MCF-7_jc5840 444 bp overlap
Stat4 4 datasets
Motif DE_36h DE_36h-Stat4_MA0518.2 10 bp overlap
Motif DE_48h DE_48h-Stat4_MA0518.2 10 bp overlap
Motif DE_60h DE_60h-Stat4_MA0518.2 10 bp overlap
Motif DE_72h DE_72h-Stat4_MA0518.2 10 bp overlap
Stat5b 4 datasets
Motif DE_36h DE_36h-Stat5b_MA1625.2 9 bp overlap
Motif DE_48h DE_48h-Stat5b_MA1625.2 9 bp overlap
Motif DE_60h DE_60h-Stat5b_MA1625.2 9 bp overlap
Motif DE_72h DE_72h-Stat5b_MA1625.2 9 bp overlap
Stat6 1 dataset
Motif DE_60h DE_60h-Stat6_MA0520.2 10 bp overlap
T 1 dataset
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 299 bp overlap
TBX5 1 dataset
ChIP hiPSC GSE81585.TBX5.hiPSC 200 bp overlap
TFAP4::FLI1 3 datasets
Motif DE_48h DE_48h-TFAP4FLI1_MA1967.2 14 bp overlap
Motif DE_60h DE_60h-TFAP4FLI1_MA1967.2 14 bp overlap
Motif DE_72h DE_72h-TFAP4FLI1_MA1967.2 14 bp overlap
TRPS1 4 datasets
Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap
Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap
Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap
Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap
Tcf12 7 datasets
Motif DE_36h DE_36h-Tcf12_MA0521.3 6 bp overlap
Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap
Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap
Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap
Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap
Motif DE_72h DE_72h-Tcf12_MA0521.3 6 bp overlap
Motif DE_72h DE_72h-Tcf12_MA0521.3 6 bp overlap
Tcf21 4 datasets
Motif DE_36h DE_36h-Tcf21_MA0832.2 10 bp overlap
Motif DE_48h DE_48h-Tcf21_MA0832.2 10 bp overlap
Motif DE_60h DE_60h-Tcf21_MA0832.2 10 bp overlap
Motif DE_72h DE_72h-Tcf21_MA0832.2 10 bp overlap
Twist2 7 datasets
Motif DE_36h DE_36h-Twist2_MA0633.3 6 bp overlap
Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap
Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap
Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap
Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap
Motif DE_72h DE_72h-Twist2_MA0633.3 6 bp overlap
Motif DE_72h DE_72h-Twist2_MA0633.3 6 bp overlap
Wt1 4 datasets
Motif DE_36h DE_36h-Wt1_MA1627.2 10 bp overlap
Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap
Motif DE_60h DE_60h-Wt1_MA1627.2 10 bp overlap
Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap
YY1 2 datasets
ChIP Hep-G2_NC GSE120104.YY1.Hep-G2_NC 488 bp overlap
ChIP Hep-G2_RBM25-KD GSE120104.YY1.Hep-G2_RBM25-KD 784 bp overlap
ZBTB42 1 dataset
ChIP HEK293 GSE76494.ZBTB42.HEK293 223 bp overlap
ZEB1 4 datasets
Motif DE_36h DE_36h-ZEB1_MA0103.4 6 bp overlap
Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap
Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap
Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap
ZEB2 1 dataset
ChIP HEK293 ENCSR417VWF.ZEB2.HEK293 269 bp overlap
ZNF10 1 dataset
ChIP HEK293 ENCSR019WUS.ZNF10.HEK293 222 bp overlap
ZNF19 1 dataset
ChIP HEK293T GSE78099.ZNF19.HEK293T 269 bp overlap
ZNF24 1 dataset
Motif DE_60h DE_60h-ZNF24_MA1124.1 13 bp overlap
ZNF257 2 datasets
ChIP HEK293 GSE76494.ZNF257.HEK293 193 bp overlap
ChIP HEK293T GSE78099.ZNF257.HEK293T 284 bp overlap
ZNF281 4 datasets
Motif DE_36h DE_36h-ZNF281_MA1630.3 10 bp overlap
Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap
Motif DE_60h DE_60h-ZNF281_MA1630.3 10 bp overlap
Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap
ZNF30 1 dataset
ChIP HEK293 GSE76494.ZNF30.HEK293 184 bp overlap
ZNF490 1 dataset
ChIP HEK293 GSE76494.ZNF490.HEK293 160 bp overlap
ZXDB 1 dataset
ChIP HEK293 ENCSR559IOZ.ZXDB.HEK293 841 bp overlap
Zfp809 4 datasets
Motif DE_36h DE_36h-Zfp809_MA2125.1 9 bp overlap
Motif DE_48h DE_48h-Zfp809_MA2125.1 9 bp overlap
Motif DE_60h DE_60h-Zfp809_MA2125.1 9 bp overlap
Motif DE_72h DE_72h-Zfp809_MA2125.1 9 bp overlap
Zic1::Zic2 4 datasets
Motif DE_36h DE_36h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_60h DE_60h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_72h DE_72h-Zic1Zic2_MA1628.2 7 bp overlap
Zic2 4 datasets
Motif DE_36h DE_36h-Zic2_MA1629.2 9 bp overlap
Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap
Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap
Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap
Zic3 4 datasets
Motif DE_36h DE_36h-Zic3_MA0697.3 7 bp overlap
Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap
Motif DE_60h DE_60h-Zic3_MA0697.3 7 bp overlap
Motif DE_72h DE_72h-Zic3_MA0697.3 7 bp overlap
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