The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZNF10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:132,887,106–132,888,371 | 242.9 kb | Distal (>10kb) Multiome | 840 | |
| chr12:132,907,962–132,909,233 | 222.0 kb | Distal (>10kb) Multiome | 481 | |
| chr12:132,955,400–132,956,621 | 174.3 kb | Distal (>10kb) Multiome | 715 | |
| chr12:132,986,063–132,986,840 | 144.3 kb | Distal (>10kb) Multiome | 840 | |
| chr12:133,036,951–133,037,971 | 93.2 kb | Distal (>10kb) Multiome | 973 | |
| chr12:133,079,789–133,081,303 | 50.2 kb | Distal (>10kb) Multiome | 937 | |
| chr12:133,129,825–133,131,032 | 167 bp | At TSS Multiome | 945 | |
| chr12:133,181,282–133,181,959 | 50.9 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the ZNF10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.