chr4:5,943,556–5,944,317

chr4 : 5,943,556 – 5,944,317

761 bp 79 TFs 7 linked genes

This 761 bp open chromatin element is linked to 7 target genes and is bound by 79 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
CRMP1		55.3 kb	Distal	Multiome
EVC		232.6 kb	Distal	Multiome
EVC2		235.3 kb	Distal	Multiome
JAKMIP1		256.7 kb	Distal	Multiome
C4orf50		256.7 kb	Distal	Multiome
ENSG00000290803		256.9 kb	Distal	Multiome
ENSG00000251408		258.5 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

79 transcription factors

ARGFX 2 datasets

Motif DE_36h DE_36h-ARGFX_MA1463.2 8 bp overlap

Motif DE_48h DE_48h-ARGFX_MA1463.2 8 bp overlap

Alx4 2 datasets

Motif DE_36h DE_36h-Alx4_MA0853.2 12 bp overlap

Motif DE_48h DE_48h-Alx4_MA0853.2 12 bp overlap

Motif DE_36h DE_36h-Arx_MA0874.2 10 bp overlap

Motif DE_48h DE_48h-Arx_MA0874.2 10 bp overlap

BARX1 2 datasets

Motif DE_36h DE_36h-BARX1_MA0875.2 6 bp overlap

Motif DE_48h DE_48h-BARX1_MA0875.2 6 bp overlap

ChIP K-562 ENCSR808AKZ.BCOR.K-562 154 bp overlap

ChIP RH4_shCHD4 GSE140115.BRD4.RH4_shCHD4 148 bp overlap

Motif DE_36h DE_36h-BSX_MA0876.2 6 bp overlap

Motif DE_48h DE_48h-BSX_MA0876.2 6 bp overlap

ChIP RH4 GSE140115.CHD4.RH4 101 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF031ISE 293 bp overlap

DLX1 2 datasets

Motif DE_36h DE_36h-DLX1_MA0879.3 6 bp overlap

Motif DE_48h DE_48h-DLX1_MA0879.3 6 bp overlap

DLX6 2 datasets

Motif DE_36h DE_36h-DLX6_MA0882.2 6 bp overlap

Motif DE_48h DE_48h-DLX6_MA0882.2 6 bp overlap

Dlx2 2 datasets

Motif DE_36h DE_36h-Dlx2_MA0885.3 8 bp overlap

Motif DE_48h DE_48h-Dlx2_MA0885.3 8 bp overlap

Dlx3 2 datasets

Motif DE_36h DE_36h-Dlx3_MA0880.2 6 bp overlap

Motif DE_48h DE_48h-Dlx3_MA0880.2 6 bp overlap

Dlx4 2 datasets

Motif DE_36h DE_36h-Dlx4_MA0881.2 6 bp overlap

Motif DE_48h DE_48h-Dlx4_MA0881.2 6 bp overlap

Dlx5 2 datasets

Motif DE_36h DE_36h-Dlx5_MA1476.3 8 bp overlap

Motif DE_48h DE_48h-Dlx5_MA1476.3 8 bp overlap

ChIP MUTUL GSE75503.EBF1.MUTUL 219 bp overlap

Motif DE_36h DE_36h-EHF_MA0598.4 9 bp overlap

Motif DE_48h DE_48h-EHF_MA0598.4 9 bp overlap

ELF3 2 datasets

Motif DE_36h DE_36h-ELF3_MA0640.3 9 bp overlap

Motif DE_48h DE_48h-ELF3_MA0640.3 9 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 403 bp overlap

Motif DE_36h DE_36h-ERF_MA0760.2 9 bp overlap

Motif DE_48h DE_48h-ERF_MA0760.2 9 bp overlap

ERF::FOXO1 2 datasets

Motif DE_36h DE_36h-ERFFOXO1_MA1936.2 12 bp overlap

Motif DE_48h DE_48h-ERFFOXO1_MA1936.2 12 bp overlap

ETS1 4 datasets

Motif DE_36h DE_36h-ETS1_MA0098.4 9 bp overlap

Motif DE_48h DE_48h-ETS1_MA0098.4 9 bp overlap

ChIP THP-6_shCtrl GSE138516.ETS1.THP-6_shCtrl 761 bp overlap

ChIP THP-6_shEts1 GSE138516.ETS1.THP-6_shEts1 592 bp overlap

ETV1 2 datasets

Motif DE_36h DE_36h-ETV1_MA0761.3 9 bp overlap

Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap

ETV2 2 datasets

Motif DE_36h DE_36h-ETV2_MA0762.2 9 bp overlap

Motif DE_48h DE_48h-ETV2_MA0762.2 9 bp overlap

ETV2::FOXI1 2 datasets

Motif DE_36h DE_36h-ETV2FOXI1_MA1942.2 11 bp overlap

Motif DE_48h DE_48h-ETV2FOXI1_MA1942.2 11 bp overlap

ChIP A-1847_CARM1-KO GSE95643.EZH2.A-1847_CARM1-KO 331 bp overlap

Motif DE_36h DE_36h-Erg_MA0474.4 10 bp overlap

Motif DE_48h DE_48h-Erg_MA0474.4 10 bp overlap

FLI1 2 datasets

Motif DE_36h DE_36h-FLI1_MA0475.3 9 bp overlap

Motif DE_48h DE_48h-FLI1_MA0475.3 9 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 414 bp overlap

ChIP DE DE-FOXA2-2 491 bp overlap

GABPA 2 datasets

Motif DE_36h DE_36h-GABPA_MA0062.4 10 bp overlap

Motif DE_48h DE_48h-GABPA_MA0062.4 10 bp overlap

GATA1 3 datasets

Motif DE_48h DE_48h-GATA1_MA0035.5 7 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 180 bp overlap

ChIP erythroid-progenitor GSE124163.GATA1.erythroid-progenitor 187 bp overlap

GATA2 1 dataset

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 184 bp overlap

GATA3 2 datasets

ChIP Jurkat GSE76181.GATA3.Jurkat 272 bp overlap

ChIP Jurkat GSE120063.GATA3.Jurkat 258 bp overlap

GATA4 7 datasets

ChIP DE DE-GATA4-1 502 bp overlap

ChIP DE DE-GATA4-2 676 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 503 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 248 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 339 bp overlap

GATA5 2 datasets

Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

GATA6 13 datasets

ChIP DE DE-GATA6-1 536 bp overlap

ChIP DE DE-GATA6-2 527 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 608 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 540 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 577 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 539 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 574 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 622 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 599 bp overlap

ChIP foregut GSE117136.GATA6.foregut 323 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 464 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 539 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 282 bp overlap

GBX2 2 datasets

Motif DE_36h DE_36h-GBX2_MA0890.2 6 bp overlap

Motif DE_48h DE_48h-GBX2_MA0890.2 6 bp overlap

HESX1 2 datasets

Motif DE_36h DE_36h-HESX1_MA0894.2 6 bp overlap

Motif DE_48h DE_48h-HESX1_MA0894.2 6 bp overlap

Motif DE_48h DE_48h-HIC2_MA0738.2 6 bp overlap

HOXA7 2 datasets

Motif DE_36h DE_36h-HOXA7_MA1498.3 6 bp overlap

Motif DE_48h DE_48h-HOXA7_MA1498.3 6 bp overlap

IKZF1 2 datasets

Motif DE_36h DE_36h-IKZF1_MA1508.2 8 bp overlap

Motif DE_48h DE_48h-IKZF1_MA1508.2 8 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 255 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 390 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 286 bp overlap

KDM1A 4 datasets

ChIP H1 ENCFF696SGD 219 bp overlap

ChIP H1 ENCFF696SGD 427 bp overlap

ChIP K-562 GSE117944.KDM1A.K-562 75 bp overlap

ChIP pancreatic-progenitor_GT GSE104840.KDM1A.pancreatic-progenitor_GT 185 bp overlap

Motif DE_48h DE_48h-KLF3_MA1516.2 10 bp overlap

Motif DE_36h DE_36h-KLF6_MA1517.2 9 bp overlap

LBX2 2 datasets

Motif DE_36h DE_36h-LBX2_MA0699.2 6 bp overlap

Motif DE_48h DE_48h-LBX2_MA0699.2 6 bp overlap

LHX2 2 datasets

Motif DE_36h DE_36h-LHX2_MA0700.3 6 bp overlap

Motif DE_48h DE_48h-LHX2_MA0700.3 6 bp overlap

Motif DE_48h DE_48h-MAF_MA1520.2 13 bp overlap

Motif DE_48h DE_48h-MAFA_MA1521.2 13 bp overlap

ChIP HCT-116_shLuc GSE121798.MED1.HCT-116_shLuc 308 bp overlap

MEIS1 3 datasets

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

MSX1 2 datasets

Motif DE_36h DE_36h-MSX1_MA0666.3 6 bp overlap

Motif DE_48h DE_48h-MSX1_MA0666.3 6 bp overlap

MSX2 2 datasets

Motif DE_36h DE_36h-MSX2_MA0708.3 6 bp overlap

Motif DE_48h DE_48h-MSX2_MA0708.3 6 bp overlap

Msx3 2 datasets

Motif DE_36h DE_36h-Msx3_MA0709.2 6 bp overlap

Motif DE_48h DE_48h-Msx3_MA0709.2 6 bp overlap

NKX2-2 2 datasets

Motif DE_36h DE_36h-NKX2-2_MA1645.2 8 bp overlap

Motif DE_48h DE_48h-NKX2-2_MA1645.2 8 bp overlap

NKX2-5 2 datasets

Motif DE_36h DE_36h-NKX2-5_MA0063.3 7 bp overlap

Motif DE_48h DE_48h-NKX2-5_MA0063.3 7 bp overlap

NOTCH1 1 dataset

ChIP HPBALL GSE39263.NOTCH1.HPBALL 138 bp overlap

Nobox 2 datasets

Motif DE_36h DE_36h-Nobox_MA0125.2 6 bp overlap

Motif DE_48h DE_48h-Nobox_MA0125.2 6 bp overlap

Prdm5 2 datasets

Motif DE_36h DE_36h-Prdm5_MA1999.2 11 bp overlap

Motif DE_48h DE_48h-Prdm5_MA1999.2 11 bp overlap

Motif DE_36h DE_36h-RAX_MA0718.2 6 bp overlap

Motif DE_48h DE_48h-RAX_MA0718.2 6 bp overlap

RBM25 3 datasets

ChIP K-562 ENCSR791OZM.RBM25.K-562 236 bp overlap

ChIP K562 ENCFF248CGR 158 bp overlap

ChIP K562 ENCFF957ORK 158 bp overlap

ChIP LNCaP_SIFOXA1_TNFA GSE83860.RELA.LNCaP_SIFOXA1_TNFA 136 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 672 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 551 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 418 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 380 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 353 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 468 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 585 bp overlap

SOX10 1 dataset

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 262 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 574 bp overlap

Six4 2 datasets

Motif DE_36h DE_36h-Six4_MA2001.2 7 bp overlap

Motif DE_48h DE_48h-Six4_MA2001.2 7 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 268 bp overlap

ZBTB26 2 datasets

Motif DE_36h DE_36h-ZBTB26_MA1579.2 8 bp overlap

Motif DE_48h DE_48h-ZBTB26_MA1579.2 8 bp overlap

ZFP42 1 dataset

Motif DE_48h DE_48h-ZFP42_MA1651.2 13 bp overlap

ZMIZ1 2 datasets

ChIP THP-6_shCtrl GSE138516.ZMIZ1.THP-6_shCtrl 470 bp overlap

ChIP THP-6_shEts1 GSE138516.ZMIZ1.THP-6_shEts1 445 bp overlap

ZMYM3 3 datasets

ChIP K-562 ENCSR102KIN.ZMYM3.K-562 193 bp overlap

ChIP K-562_Ab_JH39-2-2F10 GSE97661.ZMYM3.K-562_Ab_JH39-2-2F10 193 bp overlap

ChIP K562 ENCFF361LXT 201 bp overlap

ZNF175 2 datasets

Motif DE_36h DE_36h-ZNF175_MA2332.1 9 bp overlap

Motif DE_48h DE_48h-ZNF175_MA2332.1 9 bp overlap

ZNF214 2 datasets

Motif DE_36h DE_36h-ZNF214_MA1975.2 13 bp overlap

Motif DE_48h DE_48h-ZNF214_MA1975.2 13 bp overlap

ZNF324 1 dataset

Motif DE_48h DE_48h-ZNF324_MA1977.2 14 bp overlap

ZNF534 1 dataset

ChIP HEK293T GSE78099.ZNF534.HEK293T 88 bp overlap

ZNF629 2 datasets

ChIP Hep-G2 ENCSR363ASY.ZNF629.Hep-G2 89 bp overlap

ChIP HepG2 ENCFF490FFQ 187 bp overlap

ZSCAN21 2 datasets

Motif DE_36h DE_36h-ZSCAN21_MA2336.1 7 bp overlap

Motif DE_48h DE_48h-ZSCAN21_MA2336.1 7 bp overlap