chr2:189,960,017–189,961,026

chr2 : 189,960,017 – 189,961,026

1,009 bp 65 TFs 6 linked genes

This 1.0 kb open chromatin element is linked to 6 target genes and is bound by 65 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
C2orf88		80.8 kb	Distal	Multiome
PMS1		176.0 kb	Distal	Multiome
ORMDL1		176.1 kb	Distal	Multiome
OSGEPL1		197.7 kb	Distal	Multiome
ANKAR		285.8 kb	Distal	Multiome
ASNSD1		299.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

65 transcription factors

ARID1A 1 dataset

ChIP 12Z GSE129781.ARID1A.12Z 186 bp overlap

BCL6B 4 datasets

Motif DE_36h DE_36h-BCL6B_MA0731.1 17 bp overlap

Motif DE_48h DE_48h-BCL6B_MA0731.1 17 bp overlap

Motif DE_60h DE_60h-BCL6B_MA0731.1 17 bp overlap

Motif DE_72h DE_72h-BCL6B_MA0731.1 17 bp overlap

ChIP SK-N-BE2-C_Naive-veh GSE107706.BRD4.SK-N-BE2-C_Naive-veh 281 bp overlap

CDX2 4 datasets

Motif DE_36h DE_36h-CDX2_MA0465.3 8 bp overlap

Motif DE_48h DE_48h-CDX2_MA0465.3 8 bp overlap

Motif DE_60h DE_60h-CDX2_MA0465.3 8 bp overlap

Motif DE_72h DE_72h-CDX2_MA0465.3 8 bp overlap

CHD4 2 datasets

ChIP SCMC GSE155861.CHD4.SCMC 718 bp overlap

ChIP SCMC GSE155861.CHD4.SCMC 104 bp overlap

CTCFL 2 datasets

Motif DE_48h DE_48h-CTCFL_MA1102.3 8 bp overlap

Motif DE_60h DE_60h-CTCFL_MA1102.3 8 bp overlap

ChIP fibroblast_DOX-24h GSE134924.EGR1.fibroblast_DOX-24h 262 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 224 bp overlap

ERF::FOXI1 1 dataset

Motif DE_60h DE_60h-ERFFOXI1_MA1935.2 10 bp overlap

ChIP VCaP GSE49091.ERG.VCaP 193 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_60h DE_60h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::DRGX 2 datasets

Motif DE_48h DE_48h-ETV5DRGX_MA1944.2 12 bp overlap

Motif DE_60h DE_60h-ETV5DRGX_MA1944.2 12 bp overlap

ETV5::FOXI1 1 dataset

Motif DE_60h DE_60h-ETV5FOXI1_MA1946.2 12 bp overlap

ETV5::HOXA2 2 datasets

Motif DE_48h DE_48h-ETV5HOXA2_MA1948.2 12 bp overlap

Motif DE_60h DE_60h-ETV5HOXA2_MA1948.2 12 bp overlap

FLI1::DRGX 2 datasets

Motif DE_48h DE_48h-FLI1DRGX_MA1949.2 14 bp overlap

Motif DE_60h DE_60h-FLI1DRGX_MA1949.2 14 bp overlap

FOXA1 4 datasets

ChIP HepG2 ENCFF207NVJ 281 bp overlap

ChIP HepG2 ENCFF740VZW 285 bp overlap

ChIP VCaP_ETOH24H GSE58428.FOXA1.VCaP_ETOH24H 194 bp overlap

ChIP liver ENCSR324RCI.FOXA1.liver 177 bp overlap

FOXA2 9 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 277 bp overlap

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 428 bp overlap

ChIP DE DE-FOXA2-1 926 bp overlap

ChIP DE DE-FOXA2-2 911 bp overlap

ChIP HepG2 ENCFF570ABM 405 bp overlap

ChIP liver ENCFF888VJF 345 bp overlap

ChIP liver ENCSR080XEY.FOXA2.liver 260 bp overlap

ChIP liver_CARN1618 ERP008682.FOXA2.liver_CARN1618 232 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 370 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_60h DE_60h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA1 3 datasets

ChIP HUDEP-2_30min GSE104676.GATA1.HUDEP-2_30min 135 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 283 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 200 bp overlap

GATA2 9 datasets

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 158 bp overlap

ChIP TF1 GSE73207.GATA2.TF1 321 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 152 bp overlap

GATA3 3 datasets

ChIP Kelly GSE65664.GATA3.Kelly 200 bp overlap

ChIP SH-SY5Y ENCSR000EXZ.GATA3.SH-SY5Y 243 bp overlap

ChIP SK-N-BE2-C GSE94822.GATA3.SK-N-BE2-C 212 bp overlap

GATA4 14 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 181 bp overlap

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 251 bp overlap

ChIP DE DE-GATA4-1 879 bp overlap

ChIP DE DE-GATA4-2 1009 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 677 bp overlap

ChIP foregut GSE117136.GATA4.foregut 283 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 750 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 780 bp overlap

GATA5 6 datasets

Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 18 datasets

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 150 bp overlap

ChIP DE DE-GATA6-1 828 bp overlap

ChIP DE DE-GATA6-2 968 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 677 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 650 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 259 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 953 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 650 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 741 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 804 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 327 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 367 bp overlap

GFI1 4 datasets

Motif DE_36h DE_36h-GFI1_MA0038.3 11 bp overlap

Motif DE_48h DE_48h-GFI1_MA0038.3 11 bp overlap

Motif DE_60h DE_60h-GFI1_MA0038.3 11 bp overlap

Motif DE_72h DE_72h-GFI1_MA0038.3 11 bp overlap

Gata3 6 datasets

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HAND2 2 datasets

ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 244 bp overlap

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 382 bp overlap

HOXB13 4 datasets

Motif DE_36h DE_36h-HOXB13_MA0901.3 9 bp overlap

Motif DE_48h DE_48h-HOXB13_MA0901.3 9 bp overlap

Motif DE_60h DE_60h-HOXB13_MA0901.3 9 bp overlap

Motif DE_72h DE_72h-HOXB13_MA0901.3 9 bp overlap

Hand1::Tcf3 2 datasets

Motif DE_48h DE_48h-Hand1Tcf3_MA0092.2 9 bp overlap

Motif DE_60h DE_60h-Hand1Tcf3_MA0092.2 9 bp overlap

INSM1 1 dataset

Motif DE_60h DE_60h-INSM1_MA0155.1 12 bp overlap

ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 177 bp overlap

Irf1 4 datasets

Motif DE_48h DE_48h-Irf1_MA0050.4 11 bp overlap

Motif DE_48h DE_48h-Irf1_MA0050.4 11 bp overlap

Motif DE_60h DE_60h-Irf1_MA0050.4 11 bp overlap

Motif DE_60h DE_60h-Irf1_MA0050.4 11 bp overlap

Motif DE_48h DE_48h-JUN_MA0488.2 10 bp overlap

Motif DE_60h DE_60h-JUN_MA0488.2 10 bp overlap

JUND 2 datasets

Motif DE_48h DE_48h-JUND_MA0492.2 11 bp overlap

Motif DE_60h DE_60h-JUND_MA0492.2 11 bp overlap

MAF::NFE2 2 datasets

Motif DE_48h DE_48h-MAFNFE2_MA0501.2 11 bp overlap

Motif DE_60h DE_60h-MAFNFE2_MA0501.2 11 bp overlap

ChIP 501-mel GSE137522.MITF.501-mel 224 bp overlap

ChIP RH4 GSE155861.MTA2.RH4 180 bp overlap

ChIP SK-N-AS GSE138295.MYC.SK-N-AS 241 bp overlap

Mecom 4 datasets

Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap

Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap

Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap

Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap

NEUROD1 1 dataset

ChIP D283-Med GSE92582.NEUROD1.D283-Med 183 bp overlap

NR2C2 2 datasets

Motif DE_48h DE_48h-NR2C2_MA0504.2 14 bp overlap

Motif DE_60h DE_60h-NR2C2_MA0504.2 14 bp overlap

Nfe2l2 2 datasets

Motif DE_48h DE_48h-Nfe2l2_MA0150.3 11 bp overlap

Motif DE_60h DE_60h-Nfe2l2_MA0150.3 11 bp overlap

Nr2e3 3 datasets

Motif DE_48h DE_48h-Nr2e3_MA0164.2 6 bp overlap

Motif DE_60h DE_60h-Nr2e3_MA0164.2 6 bp overlap

Motif DE_72h DE_72h-Nr2e3_MA0164.2 6 bp overlap

ONECUT1 2 datasets

ChIP H9 ERP004206.ONECUT1.H9 409 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.ONECUT1.pancreatic-progenitor_PP1 364 bp overlap

PRDM9 2 datasets

Motif DE_48h DE_48h-PRDM9_MA1723.2 20 bp overlap

Motif DE_60h DE_60h-PRDM9_MA1723.2 20 bp overlap

Pparg::Rxra 2 datasets

Motif DE_48h DE_48h-PpargRxra_MA0065.3 13 bp overlap

Motif DE_60h DE_60h-PpargRxra_MA0065.3 13 bp overlap

Prdm4 2 datasets

Motif DE_48h DE_48h-Prdm4_MA1647.3 11 bp overlap

Motif DE_60h DE_60h-Prdm4_MA1647.3 11 bp overlap

RBBP4 2 datasets

ChIP RH5 GSE155861.RBBP4.RH5 199 bp overlap

ChIP SCMC GSE155861.RBBP4.SCMC 759 bp overlap

ChIP liver ENCFF077DAP 465 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 794 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 651 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 337 bp overlap

SMARCA4 1 dataset

ChIP NGP_ARID1A-mut2 GSE134626.SMARCA4.NGP_ARID1A-mut2 213 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 265 bp overlap

SPIB 2 datasets

Motif DE_48h DE_48h-SPIB_MA0081.3 13 bp overlap

Motif DE_60h DE_60h-SPIB_MA0081.3 13 bp overlap

Motif DE_60h DE_60h-SPIC_MA0687.2 13 bp overlap

STAT1::STAT2 4 datasets

Motif DE_36h DE_36h-STAT1STAT2_MA0517.2 13 bp overlap

Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap

Motif DE_60h DE_60h-STAT1STAT2_MA0517.2 13 bp overlap

Motif DE_72h DE_72h-STAT1STAT2_MA0517.2 13 bp overlap

Spi1 2 datasets

Motif DE_48h DE_48h-Spi1_MA0080.7 13 bp overlap

Motif DE_60h DE_60h-Spi1_MA0080.7 13 bp overlap

Stat2 4 datasets

Motif DE_48h DE_48h-Stat2_MA1623.2 10 bp overlap

Motif DE_48h DE_48h-Stat2_MA1623.2 10 bp overlap

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

ChIP ProEs GSE59087.TAL1.ProEs 136 bp overlap

TRPS1 6 datasets

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ZFP14 1 dataset

Motif DE_60h DE_60h-ZFP14_MA1972.1 15 bp overlap

ZNF184 2 datasets

Motif DE_48h DE_48h-ZNF184_MA2120.1 13 bp overlap

Motif DE_60h DE_60h-ZNF184_MA2120.1 13 bp overlap

ZNF281 2 datasets

Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap

Motif DE_60h DE_60h-ZNF281_MA1630.3 10 bp overlap

ZNF558 4 datasets

Motif DE_36h DE_36h-ZNF558_MA2335.1 29 bp overlap

Motif DE_48h DE_48h-ZNF558_MA2335.1 29 bp overlap

Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap

Motif DE_72h DE_72h-ZNF558_MA2335.1 29 bp overlap

ZNF582 2 datasets

Motif DE_48h DE_48h-ZNF582_MA1983.2 19 bp overlap

Motif DE_60h DE_60h-ZNF582_MA1983.2 19 bp overlap