Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C2orf88. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2orf88 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2orf88, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:189,580,171–189,582,155 | 298.8 kb | Distal (>10kb) Multiome | 892 | |
| chr2:189,660,922–189,661,904 | 218.2 kb | Distal (>10kb) Multiome | 868 | |
| chr2:189,673,963–189,675,142 | 205.1 kb | Distal (>10kb) Multiome | 910 | |
| chr2:189,762,270–189,763,426 | 116.9 kb | Distal (>10kb) Multiome | 951 | |
| chr2:189,783,493–189,785,050 | 95.3 kb | Distal (>10kb) Multiome | 1120 | |
| chr2:189,879,173–189,881,360 | 1.0 kb | Proximal (<10kb) Multiome | 252 | |
| chr2:189,885,105–189,885,710 | 5.5 kb | Proximal (<10kb) | 42 | |
| chr2:189,960,017–189,961,026 | 80.8 kb | Distal (>10kb) Multiome | 65 | |
| chr2:190,119,022–190,119,699 | 239.8 kb | Distal (>10kb) Multiome | 98 | |
| chr2:190,149,889–190,150,657 | at TSS | At TSS | 40 | |
| chr2:190,168,959–190,170,203 | 289.9 kb | Distal (>10kb) Multiome | 174 | |
| chr2:190,177,206–190,177,559 | 2.9 kb | Proximal (<10kb) | 18 | |
| chr2:190,179,802–190,181,497 | 300.9 kb | Distal (>10kb) Multiome | 911 | |
| chr2:190,319,052–190,320,177 | 440.3 kb | Distal (>10kb) Multiome HiCAR | 934 | |
| chr2:190,343,052–190,344,699 | 464.4 kb | Distal (>10kb) Multiome | 922 | |
| chr2:190,407,333–190,409,184 | 528.8 kb | Distal (>10kb) Multiome | 669 |
Genomic view of the C2orf88 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.