chr2:99,081,586–99,082,682

chr2 : 99,081,586 – 99,082,682

1,096 bp 73 TFs 6 linked genes

This 1.1 kb open chromatin element is linked to 6 target genes and is bound by 73 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TSGA10		72.8 kb	Distal	Multiome
LIPT1		72.8 kb	Distal	Multiome
MITD1		98.9 kb	Distal	Multiome
MRPL30		99.0 kb	Distal	Multiome
TXNDC9		254.3 kb	Distal	Multiome
EIF5B		255.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

73 transcription factors

ASCL1 1 dataset

Motif DE_48h DE_48h-ASCL1_MA1631.2 9 bp overlap

ChIP K-562 ENCSR000ATW.CBX8.K-562 96 bp overlap

CEBPD 2 datasets

Motif DE_48h DE_48h-CEBPD_MA0836.3 8 bp overlap

Motif DE_60h DE_60h-CEBPD_MA0836.3 8 bp overlap

Dmrt1 1 dataset

Motif DE_60h DE_60h-Dmrt1_MA1603.2 9 bp overlap

EOMES 1 dataset

Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap

ChIP dermal-fibroblast_Untransformed GSE126396.EZH2.dermal-fibroblast_Untransformed 228 bp overlap

FIGLA 1 dataset

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 960 bp overlap

ChIP DE DE-FOXA2-2 781 bp overlap

Foxq1 2 datasets

Motif DE_60h DE_60h-Foxq1_MA0040.2 10 bp overlap

Motif DE_72h DE_72h-Foxq1_MA0040.2 10 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 650 bp overlap

ChIP DE DE-GATA4-2 753 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 241 bp overlap

GATA5 4 datasets

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 587 bp overlap

ChIP DE DE-GATA6-2 877 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 957 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 973 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 1045 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 571 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 1035 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 1051 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 297 bp overlap

Gata3 1 dataset

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

HNF4A 2 datasets

Motif DE_60h DE_60h-HNF4A_MA0114.5 9 bp overlap

Motif DE_72h DE_72h-HNF4A_MA0114.5 9 bp overlap

HNF4G 2 datasets

Motif DE_60h DE_60h-HNF4G_MA0484.3 9 bp overlap

Motif DE_72h DE_72h-HNF4G_MA0484.3 9 bp overlap

HOXC13 2 datasets

Motif DE_60h DE_60h-HOXC13_MA0907.2 9 bp overlap

Motif DE_72h DE_72h-HOXC13_MA0907.2 9 bp overlap

Hnf1A 3 datasets

Motif DE_48h DE_48h-Hnf1A_MA1991.2 10 bp overlap

Motif DE_60h DE_60h-Hnf1A_MA1991.2 10 bp overlap

Motif DE_72h DE_72h-Hnf1A_MA1991.2 10 bp overlap

IKZF2 4 datasets

Motif DE_36h DE_36h-IKZF2_MA2326.1 6 bp overlap

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

Motif DE_60h DE_60h-IKZF2_MA2326.1 6 bp overlap

Motif DE_72h DE_72h-IKZF2_MA2326.1 6 bp overlap

Lef1 3 datasets

Motif DE_48h DE_48h-Lef1_MA0768.3 8 bp overlap

Motif DE_60h DE_60h-Lef1_MA0768.3 8 bp overlap

Motif DE_72h DE_72h-Lef1_MA0768.3 8 bp overlap

Lhx3 3 datasets

Motif DE_48h DE_48h-Lhx3_MA0135.2 12 bp overlap

Motif DE_60h DE_60h-Lhx3_MA0135.2 12 bp overlap

Motif DE_72h DE_72h-Lhx3_MA0135.2 12 bp overlap

MAFF 3 datasets

Motif DE_48h DE_48h-MAFF_MA0495.4 11 bp overlap

Motif DE_60h DE_60h-MAFF_MA0495.4 11 bp overlap

Motif DE_72h DE_72h-MAFF_MA0495.4 11 bp overlap

Mafb 3 datasets

Motif DE_48h DE_48h-Mafb_MA0117.3 11 bp overlap

Motif DE_60h DE_60h-Mafb_MA0117.3 11 bp overlap

Motif DE_72h DE_72h-Mafb_MA0117.3 11 bp overlap

Msgn1 2 datasets

Motif DE_60h DE_60h-Msgn1_MA1524.3 10 bp overlap

Motif DE_72h DE_72h-Msgn1_MA1524.3 10 bp overlap

NANOG 2 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 300 bp overlap

ChIP hESC GSE18292.NANOG.hESC 97 bp overlap

Motif DE_48h DE_48h-NRL_MA0842.3 12 bp overlap

Motif DE_60h DE_60h-NRL_MA0842.3 12 bp overlap

Motif DE_72h DE_72h-NRL_MA0842.3 12 bp overlap

PLAG1 2 datasets

Motif DE_60h DE_60h-PLAG1_MA0163.1 14 bp overlap

Motif DE_72h DE_72h-PLAG1_MA0163.1 14 bp overlap

POU2F1::SOX2 2 datasets

Motif DE_60h DE_60h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif DE_72h DE_72h-POU2F1SOX2_MA1962.1 17 bp overlap

POU5F1 1 dataset

ChIP HUES-8 GSE109524.POU5F1.HUES-8 267 bp overlap

Plagl1 2 datasets

Motif DE_60h DE_60h-Plagl1_MA1615.2 8 bp overlap

Motif DE_72h DE_72h-Plagl1_MA1615.2 8 bp overlap

Pou5f1::Sox2 3 datasets

Motif DE_48h DE_48h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_60h DE_60h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_72h DE_72h-Pou5f1Sox2_MA0142.1 15 bp overlap

Prdm14 2 datasets

Motif DE_48h DE_48h-Prdm14_MA1998.2 8 bp overlap

Motif DE_60h DE_60h-Prdm14_MA1998.2 8 bp overlap

Prdm15 2 datasets

Motif DE_48h DE_48h-Prdm15_MA1616.2 11 bp overlap

Motif DE_60h DE_60h-Prdm15_MA1616.2 11 bp overlap

RBPJ 4 datasets

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap

RNF2 4 datasets

ChIP K-562 ENCSR820GND.RNF2.K-562 323 bp overlap

ChIP K-562 ENCSR820GND.RNF2.K-562 168 bp overlap

ChIP fibroblast GSE139053.RNF2.fibroblast 290 bp overlap

ChIP fibroblast GSE139053.RNF2.fibroblast 102 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 1005 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 706 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 691 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 864 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 596 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 262 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 275 bp overlap

SMARCA4 1 dataset

ChIP K-562 ENCSR643VTW.SMARCA4.K-562 122 bp overlap

SMARCC1 3 datasets

ChIP ESC S25-ESC-d0-BAF155-exp1 280 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 163 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 178 bp overlap

SOX10 2 datasets

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

SOX12 2 datasets

Motif DE_60h DE_60h-SOX12_MA1561.2 10 bp overlap

Motif DE_72h DE_72h-SOX12_MA1561.2 10 bp overlap

SOX14 2 datasets

Motif DE_60h DE_60h-SOX14_MA1562.2 9 bp overlap

Motif DE_72h DE_72h-SOX14_MA1562.2 9 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 479 bp overlap

SOX4 2 datasets

Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap

Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap

SOX8 2 datasets

Motif DE_60h DE_60h-SOX8_MA0868.3 7 bp overlap

Motif DE_72h DE_72h-SOX8_MA0868.3 7 bp overlap

Motif DE_60h DE_60h-SRY_MA0084.2 7 bp overlap

Motif DE_72h DE_72h-SRY_MA0084.2 7 bp overlap

Sox5 3 datasets

Motif DE_48h DE_48h-Sox5_MA0087.3 8 bp overlap

Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap

Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap

Stat5b 2 datasets

Motif DE_48h DE_48h-Stat5b_MA1625.2 9 bp overlap

Motif DE_60h DE_60h-Stat5b_MA1625.2 9 bp overlap

Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

TBX18 1 dataset

Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap

Motif DE_60h DE_60h-TBX2_MA0688.2 9 bp overlap

TBX20 1 dataset

Motif DE_60h DE_60h-TBX20_MA0689.1 11 bp overlap

TBX21 1 dataset

Motif DE_60h DE_60h-TBX21_MA0690.3 10 bp overlap

Motif DE_60h DE_60h-TBX3_MA1566.3 9 bp overlap

Motif DE_48h DE_48h-TCF4_MA0830.3 8 bp overlap

TCF7L2 3 datasets

Motif DE_48h DE_48h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_60h DE_60h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_72h DE_72h-TCF7L2_MA0523.2 9 bp overlap

TRPS1 1 dataset

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-Tbx6_MA1567.3 9 bp overlap

ZBTB12 3 datasets

Motif DE_48h DE_48h-ZBTB12_MA1649.2 7 bp overlap

Motif DE_60h DE_60h-ZBTB12_MA1649.2 7 bp overlap

Motif DE_72h DE_72h-ZBTB12_MA1649.2 7 bp overlap

ZBTB7B 4 datasets

Motif DE_36h DE_36h-ZBTB7B_MA0694.2 10 bp overlap

Motif DE_48h DE_48h-ZBTB7B_MA0694.2 10 bp overlap

Motif DE_60h DE_60h-ZBTB7B_MA0694.2 10 bp overlap

Motif DE_72h DE_72h-ZBTB7B_MA0694.2 10 bp overlap

ZBTB7C 4 datasets

Motif DE_36h DE_36h-ZBTB7C_MA0695.2 8 bp overlap

Motif DE_48h DE_48h-ZBTB7C_MA0695.2 8 bp overlap

Motif DE_60h DE_60h-ZBTB7C_MA0695.2 8 bp overlap

Motif DE_72h DE_72h-ZBTB7C_MA0695.2 8 bp overlap

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

Motif DE_60h DE_60h-ZIM3_MA1709.2 11 bp overlap

ZNF214 2 datasets

Motif DE_48h DE_48h-ZNF214_MA1975.2 13 bp overlap

Motif DE_60h DE_60h-ZNF214_MA1975.2 13 bp overlap

ZNF257 4 datasets

Motif DE_36h DE_36h-ZNF257_MA1710.2 10 bp overlap

Motif DE_48h DE_48h-ZNF257_MA1710.2 10 bp overlap

Motif DE_60h DE_60h-ZNF257_MA1710.2 10 bp overlap

Motif DE_72h DE_72h-ZNF257_MA1710.2 10 bp overlap

ZNF558 1 dataset

Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap

ZNF652 4 datasets

Motif DE_36h DE_36h-ZNF652_MA1657.2 9 bp overlap

Motif DE_48h DE_48h-ZNF652_MA1657.2 9 bp overlap

Motif DE_60h DE_60h-ZNF652_MA1657.2 9 bp overlap

Motif DE_72h DE_72h-ZNF652_MA1657.2 9 bp overlap

ZNF667 2 datasets

Motif DE_60h DE_60h-ZNF667_MA1984.2 11 bp overlap

Motif DE_72h DE_72h-ZNF667_MA1984.2 11 bp overlap

ZNF675 2 datasets

Motif DE_60h DE_60h-ZNF675_MA1714.2 19 bp overlap

Motif DE_72h DE_72h-ZNF675_MA1714.2 19 bp overlap

ZNF707 2 datasets

Motif DE_48h DE_48h-ZNF707_MA1715.1 15 bp overlap

Motif DE_60h DE_60h-ZNF707_MA1715.1 15 bp overlap

ZNF85 1 dataset

Motif DE_60h DE_60h-ZNF85_MA1720.2 12 bp overlap

ZSCAN16 4 datasets

Motif DE_36h DE_36h-ZSCAN16_MA2100.1 18 bp overlap

Motif DE_48h DE_48h-ZSCAN16_MA2100.1 18 bp overlap

Motif DE_60h DE_60h-ZSCAN16_MA2100.1 18 bp overlap

Motif DE_72h DE_72h-ZSCAN16_MA2100.1 18 bp overlap

Zfp809 2 datasets

Motif DE_60h DE_60h-Zfp809_MA2125.1 9 bp overlap

Motif DE_72h DE_72h-Zfp809_MA2125.1 9 bp overlap