The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TXNDC9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXNDC9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXNDC9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:99,081,586–99,082,682 | 254.3 kb | Distal (>10kb) Multiome | 73 | |
| chr2:99,140,631–99,142,044 | 195.0 kb | Distal (>10kb) Multiome | 976 | |
| chr2:99,154,503–99,155,535 | 181.4 kb | Distal (>10kb) Multiome | 1013 | |
| chr2:99,180,725–99,181,615 | 155.2 kb | Distal (>10kb) Multiome | 1014 | |
| chr2:99,335,843–99,338,098 | 1.1 kb | Proximal (<10kb) Multiome | 1129 | |
| chr2:99,489,057–99,490,837 | 153.8 kb | Distal (>10kb) Multiome | 982 |
Genomic view of the TXNDC9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.